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Autor:
Matteo Andreini, Stefan Steinbacher, Antonino Missineo, Georg Kempf, Ignacio Munoz-Sanjuan, Licia Tomei, Vincenzo Summa, Tommaso Frattarelli, D. De Simone, Mauro Cerretani, Leticia Toledo-Sherman, Celia Dominguez, Martin Augustin, Elisabetta Bianchi, Daniele Moretti, Sara Tambone, Stefania Colarusso, Larry Park, Alberto Bresciani
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115738
Inhibition of KEAP1-NRF2 protein-protein interaction is considered a promising strategy to selectively and effectively activate NRF2, a transcription factor which is involved in several pathologies such as Huntington's disease (HD). A library of line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489702ad5ac860849caf323775f152eb
https://doi.org/10.1016/j.bmc.2020.115738
https://doi.org/10.1016/j.bmc.2020.115738
Autor:
Adams GL; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Pall PS; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Grauer SM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Zhou X; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Ballard JE; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Vavrek M; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kraus RL; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Morissette P; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Li N; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Colarusso S; Peptides and Small Molecules R&D Department, IRBM Spa, Via Pontina km 30.600, 00071 Pomezia (RM), Italy., Bianchi E; Peptides and Small Molecules R&D Department, IRBM Spa, Via Pontina km 30.600, 00071 Pomezia (RM), Italy., Palani A; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Klein R; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., John CT; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Wang D; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Tudor M; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Nolting AF; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Biba M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Nowak T; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Makarov AA; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Reibarkh M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Buevich AV; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Zhong W; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Regalado EL; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wang X; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Gao Q; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Shahripour A; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Zhu Y; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., de Simone D; Peptides and Small Molecules R&D Department, IRBM Spa, Via Pontina km 30.600, 00071 Pomezia (RM), Italy., Frattarelli T; Peptides and Small Molecules R&D Department, IRBM Spa, Via Pontina km 30.600, 00071 Pomezia (RM), Italy., Pasquini NM; Peptides and Small Molecules R&D Department, IRBM Spa, Via Pontina km 30.600, 00071 Pomezia (RM), Italy., Magotti P; Peptides and Small Molecules R&D Department, IRBM Spa, Via Pontina km 30.600, 00071 Pomezia (RM), Italy., Iaccarino R; Peptides and Small Molecules R&D Department, IRBM Spa, Via Pontina km 30.600, 00071 Pomezia (RM), Italy., Li Y; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Solly K; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Lee KJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wang W; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Chen F; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Zeng H; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Wang J; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Regan H; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Amin RP; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Regan CP; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Burgey CS; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Henze DA; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Sun C; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Tellers DM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2022 Jan 13; Vol. 65 (1), pp. 485-496. Date of Electronic Publication: 2021 Dec 21.