Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Fraser W Scott"'
Autor:
Brigitte Sonier, Alexander Strom, Gen-Sheng Wang, Christopher Patrick, Jennifer A Crookshank, Majid Mojibian, Amanda J MacFarlane, Fraser W Scott
Publikováno v:
Canadian Journal of Gastroenterology, Vol 25, Iss 6, Pp 327-329 (2011)
Antibodies against the wheat storage globulin Glo-3A from a patient with both type 1 diabetes (T1D) and celiac disease were enriched to identify potential molecular mimicry between wheat antigens and T1D target tissues. Recombinant Glo-3A was used to
Externí odkaz:
https://doaj.org/article/f7dfb079d7464322b1cdaeefd9e76806
Autor:
Alexander Strom, Barbara Yutzy, Carina Kruip, Mark Ooms, Nanette C Schloot, Michael Roden, Fraser W Scott, Johannes Loewer, Edgar Holznagel
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104343 (2014)
Obesity has become one of the largest public health challenges worldwide. Recently, certain bacterial and viral pathogens have been implicated in the pathogenesis of obesity. In the present study, we retrospectively analyzed clinical data, plasma sam
Externí odkaz:
https://doaj.org/article/42599e8b65514efe86807dcff2e8c4a2
Autor:
Molly M Lamb, Melissa D Simpson, Jennifer Seifert, Fraser W Scott, Marian Rewers, Jill M Norris
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57936 (2013)
Infant dietary exposures have been linked to type 1 diabetes (T1D) development. IgG4 antibody responses to food antigens are associated with food intolerances but have not been explored prospectively in the period preceding T1D.Using a case-cohort de
Externí odkaz:
https://doaj.org/article/579930facadf48e3856b19bb59a4ec80
Autor:
B. S. Morgan, Fraser W. Scott, R. W. Mueller, M. F. Paré, Jennifer A. Crookshank, D. Serrano, L. Marandi, P. Poussier
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
In a previous study we reported that prediabetic rats have a unique gene signature that was apparent even in neonates. Several of the changes we observed, including enhanced expression of pro-inflammatory genes and dysregulated UPR and metabolism gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e855c4121c86aceddc181abc84df7a5
https://doi.org/10.1038/s41598-019-51143-7
https://doi.org/10.1038/s41598-019-51143-7
Autor:
Fraser W. Scott
Publikováno v:
Diet, Nutrition, and Immunity ISBN: 9781351071390
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1e5da8ec24bc3f2feef8dace7668935
https://doi.org/10.1201/9781351071390-7
https://doi.org/10.1201/9781351071390-7
Autor:
Walid Mottawea, Alain Stintzi, Fraser W. Scott, Christopher Patrick, Gen-Sheng Wang, Lynley D. Pound, Roxanne Vandenbeek, Turki S. Abujamel, Chandra E. Eberhard
Publikováno v:
Diabetes. 64:4135-4147
Cathelicidin antimicrobial peptide (CAMP) is a naturally occurring secreted peptide that is expressed in several organs with pleiotropic roles in immunomodulation, wound healing, and cell growth. We previously demonstrated that gut Camp expression is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce45a471137793affce590679a56c7ea
https://doi.org/10.2337/db15-0788
https://doi.org/10.2337/db15-0788
Autor:
Christopher Patrick, Mahmoud Husseini, Amanda J. MacFarlane, Gen-Sheng Wang, Alexander Strom, Fraser W. Scott, Jennifer A. Crookshank, J. Ariana Noel
Publikováno v:
Endocrinology. 156:3937-3949
Immunoregulatory and regenerative processes are activated in the pancreas during the development of type 1 diabetes (T1D) but are insufficient to prevent the disease. We hypothesized that the induction of cytoprotective heme oxygenase-1 (HO-1) by cob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c46d9e14e506aae87a42aa1b1d866e1
https://doi.org/10.1210/en.2015-1304
https://doi.org/10.1210/en.2015-1304
Publikováno v:
Immunology. 145:417-428
The gut immune system and its modification by diet have been implicated in the pathogenesis of type 1 diabetes (T1D). Therefore, we investigated gut immune status in non-diabetes-prone LEW.1AR1 and diabetes-prone LEW.1AR1-iddm rats and evaluated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d9ab6a8d110826576c8a8c4cdc4110
https://doi.org/10.1111/imm.12457
https://doi.org/10.1111/imm.12457
Autor:
Majambu Mbikay, Andrew Chen, Fraser W. Scott, Francine Sirois, Charles Gyamera-Acheampong, Gen-Sheng Wang, Peter Rippstein, Michel Chrétien, Janice Mayne
Publikováno v:
Journal of Diabetes. 7:74-84
Background Proprotein convertase subtilisin/kexin-type 9 (PCSK9) downregulates clearance of plasma cholesterol by liver. Its inactivation increases this clearance, reducing cardiovascular risk. However, a lack of PCSK9 could also lead to cholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f675f6c824c0d9330353ba295f3d63ed
https://doi.org/10.1111/1753-0407.12139
https://doi.org/10.1111/1753-0407.12139
Autor:
Gen-Sheng Wang, Dirk Wedekind, Conny Gysemans, Lorella Marselli, Hans-Jürgen Hedrich, Sigurd Lenzen, Yutaka Nakaya, Piero Marchetti, Fraser W. Scott, T Arndt, Jürgen Klempnauer, Chantal Mathieu, Andreas Meyer zu Vilsendorf, Anne Jörns, Nagakatsu Harada
Publikováno v:
Diabetologia; Vol 57
Research on the pathogenesis of type 1 diabetes relies heavily on good animal models. The aim of this work was to study the translational value of animal models of type 1 diabetes to the human situation.We compared the four major animal models of spo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5d9f05654439b67da06497382547ce
https://doi.org/10.1007/s00125-013-3125-4
https://doi.org/10.1007/s00125-013-3125-4