Zobrazeno 1 - 3
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pro vyhledávání: '"Fraser P. McCready"'
Autor:
Kartik S. Pradeepan, Fraser P. McCready, Wei Wei, Milad Khaki, Wenbo Zhang, Michael W. Salter, James Ellis, Julio Martinez-Trujillo
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 2, Pp 100290- (2024)
Background: Mutations in MECP2 predominantly cause Rett syndrome and can be modeled in vitro using human stem cell–derived neurons. Patients with Rett syndrome have signs of cortical hyperexcitability, such as seizures. Human stem cell–derived ME
Externí odkaz:
https://doaj.org/article/bf64c74f1669454c9420b1a4508cfb26
Autor:
Fraser P. McCready, Sara Gordillo-Sampedro, Kartik Pradeepan, Julio Martinez-Trujillo, James Ellis
Publikováno v:
Biology, Vol 11, Iss 2, p 316 (2022)
In vitro multielectrode array (MEA) systems are increasingly used as higher-throughput platforms for functional phenotyping studies of neurons in induced pluripotent stem cell (iPSC) disease models. While MEA systems generate large amounts of spatiot
Externí odkaz:
https://doaj.org/article/91483c8d96d74c27b01c34ebc9f98381
Autor:
Alina Piekna, Michael W. Salter, Eric Deneault, Stephen W. Scherer, Peter Pasceri, Wei Wei, Tadeo Thompson, James Ellis, P. Joel Ross, Fraser P. McCready, Deivid C. Rodrigues, Kirill Zaslavsky, Wen-Bo Zhang, Melody Zhao, Joelle El Hajjar, Caitlin Loo, Zhuozhi Wang, Marat Mufteev, Shahryar Khattak, Asli Romm
Publikováno v:
Nature neuroscience
Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum disorder (ASD). We generated cortical neurons from induced pluripotent stem cells (iPSC) derived from neurotypic and ASD-affected donors. We developed Sparse cocult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0776292618444005f36b2530015f2e
https://doi.org/10.1038/s41593-019-0365-8
https://doi.org/10.1038/s41593-019-0365-8