Výsledky vyhledávání - "Fraser Mitchell"

Akademický článek

Reflections on the Process of Conducting Secondary Analysis of Qualitative Data Concerning Informed Choice for Young People With a Disability in Transition

Autor: Fraser Mitchell

Publikováno v: Forum: Qualitative Social Research, Vol 16, Iss 3 (2015)

Secondary analysis of data is seen as a way of maximising the utility of existing research in a non-intrusive way and provides an efficient research strategy at a time of financial constraint. However, there are few examples from the published litera

Externí odkaz: https://doaj.org/article/c93182479a6642dea3bfe3bc7dd22c6e

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Akademický článek

Multi-modal analysis of courtship behaviour in the old world leishmaniasis vector Phlebotomus argentipes.

Autor: Daniel P Bray, Khatijah Yaman, Beryl A Underhilll, Fraser Mitchell, Victoria Carter, James G C Hamilton

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 12, p e3316 (2014)

BACKGROUND:The sand fly Phlebotomus argentipes is arguably the most important vector of leishmaniasis worldwide. As there is no vaccine against the parasites that cause leishmaniasis, disease prevention focuses on control of the insect vector. Unders

Externí odkaz: https://doaj.org/article/dcfc1a5f060f4a8fbc61533d1a8bcbca

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Data from BGC 945, a Novel Tumor-Selective Thymidylate Synthase Inhibitor Targeted to α-Folate Receptor–Overexpressing Tumors

Autor: Ann L. Jackman, Elisa Henderson, Vassilios Bavetsias, Fraser Mitchell, Martin D. Forster, Melanie Valenti, Florence Raynaud, Matthew Green, Nadya Wood, Davinder S. Theti, David D. Gibbs

BGC 945 is a cyclopenta[g]quinazoline–based, thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)–overexpressing tumors. Affinity of BGC 945 for the α-FR is 70% of the high-affinity ligand folic acid. In contra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4e2ec2a7b73cd5371c1c39e0a449b7
https://doi.org/10.1158/0008-5472.c.6494742

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Data from Imaging Pharmacodynamics of the α-Folate Receptor–Targeted Thymidylate Synthase Inhibitor BGC 945

Autor: Eric O. Aboagye, Ann L. Jackman, Oksana Golovko, Franklin I. Aibgirhio, Julius Leyton, Fraser Mitchell, Meg Perumal, Martin Forster, Radhakrishna G. Pillai

The assessment of tissue-specific pharmacodynamics is desirable in the development of tumor-targeted therapies. Plasma deoxyuridine (dUrd) levels, a measure of systemic thymidylate synthase (TS) inhibition, has limited application for studying the ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ef0d89521a37fd92bc011a1edcf6aa
https://doi.org/10.1158/0008-5472.c.6497175

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