Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Fraser McBlane"'
Autor:
Tong-yuan Yang, Manuela Braun, Wibke Lembke, Fraser McBlane, John Kamerud, Stephen DeWall, Edit Tarcsa, Xiaodong Fang, Lena Hofer, Uma Kavita, Vijay V. Upreti, Swati Gupta, LiNa Loo, Alison J. Johnson, Rakesh Kantilal Chandode, Kay-Gunnar Stubenrauch, Maya Vinzing, Cindy Q. Xia, Vibha Jawa
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 471-494 (2022)
Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-associated virus (AAV) vector-based gene therapies. Mild to severe adverse events observed in clinical development have been implicated with host immune responses again
Externí odkaz:
https://doaj.org/article/1b85bb2274f44631a3d3b829f5704b0f
Autor:
Kristian Helin, Jesper Christensen, Maria Capra, Giovanni Pacchiana, Paolo Nucifero, Fraser McBlane, Julian Walfridsson, Ursula Grazini, Micaela Quarto, Elena Prosperini, Marco Ciró
The E2F and MYC transcription factors are critical regulators of cell proliferation and contribute to the development of human cancers. Here, we report on the identification of a novel E2F target gene, ATAD2, the predicted protein product of which co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96a3964bcd2de3f0c64ec83629d9c7f8
https://doi.org/10.1158/0008-5472.c.6500342
https://doi.org/10.1158/0008-5472.c.6500342
Autor:
Andy Warren, Michael A. Pulsipher, Theodore W. Laetsch, Stephen J. Schuster, G. Doug Myers, Peter Borchmann, John E. Levine, Michael Boyer, Edmund K. Waller, Edward Waldron, Stephan A. Grupp, Bernd Potthoff, Karen Thudium Mueller, Andrea Chassot-Agostinho, Ulrich Jaeger, Stephen Ronan Foley, Constantine S. Tam, Rakesh Awasthi, Keith J. August, Shannon L. Maude, Fraser McBlane
Publikováno v:
Blood Advances. 5:4980-4991
Tisagenlecleucel is indicated for pediatric and young adult patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL) and adult patients with r/r diffuse large B-cell lymphoma (DLBCL). The tisagenlecleucel chimeric antigen r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c056580c860ba6ef2dd3282aa8e3b47
https://doi.org/10.1182/bloodadvances.2020003844
https://doi.org/10.1182/bloodadvances.2020003844
Autor:
Andrew M. Stein, Rakesh Awasthi, G. Doug Myers, Edward Waldron, Xu Zhu, Fraser McBlane, Edmund K. Waller, John E. Levine, Stephan A. Grupp, Michael A. Pulsipher, Anwesha Chaudhury
Publikováno v:
Cancer Research. 81:509-509
Objectives: Cellular kinetic (CK) measurement of CAR-T cell expansion in-vivo by quantitative polymerase chain reaction (qPCR) has been measured in units of transgene copy number/μg of DNA. We propose a formula to convert the qPCR, and flow cytometr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7530ea05ce6818b0d3cd4248ac12d23
https://doi.org/10.1158/1538-7445.am2021-509
https://doi.org/10.1158/1538-7445.am2021-509
Publikováno v:
Journal of immunological methods. 476
The use of T-cells expressing Chimeric Antigen Receptors (CARs) offers new opportunities for cancer treatment, as well as new challenges for the bioanalysis of this new class of drugs. The analysis of humoral immunogenicity (anti-drug antibodies) aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f324263bc50a39ceef073c15b1f656fa
https://pubmed.ncbi.nlm.nih.gov/31678267
https://pubmed.ncbi.nlm.nih.gov/31678267
Autor:
Marco Fabbri, Fraser McBlane, Andrea Cocito, Ursula Grazini, Ivan Merelli, Raoul J. P. Bonnal, Luciano Milanesi, Alessandro Guffanti, Laura Furia
Publikováno v:
Nucleic Acids Research
Nucleic acids research 32 (2010): W262–W267. doi:10.1093/nar/gkq391
info:cnr-pdr/source/autori:Merelli I.; Guffanti A.; Fabbri M.; Cocito A.; Furia L.; Grazini U.; Bonnal R.J.; Milanesi L.; McBlane F./titolo:RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes/doi:10.1093%2Fnar%2Fgkq391/rivista:Nucleic acids research/anno:2010/pagina_da:W262/pagina_a:W267/intervallo_pagine:W262–W267/volume:32
Nucleic acids research 32 (2010): W262–W267. doi:10.1093/nar/gkq391
info:cnr-pdr/source/autori:Merelli I.; Guffanti A.; Fabbri M.; Cocito A.; Furia L.; Grazini U.; Bonnal R.J.; Milanesi L.; McBlane F./titolo:RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes/doi:10.1093%2Fnar%2Fgkq391/rivista:Nucleic acids research/anno:2010/pagina_da:W262/pagina_a:W267/intervallo_pagine:W262–W267/volume:32
Recombination signal sequences (RSSs) flanking V, D and J gene segments are recognized and cut by the VDJ recombinase during development of B and T lymphocytes. All RSSs are composed of seven conserved nucleotides, followed by a spacer (containing ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70194aa5640779a7e190acdd3e042532
https://doi.org/10.1093/nar/gkq391
https://doi.org/10.1093/nar/gkq391
Autor:
Jesper Christensen, Ursula Grazini, Kristian Helin, Fraser McBlane, Paolo Nucifero, M Quarto, Giovanni Pacchiana, Maria Capra, Julian Walfridsson, Elena Prosperini, Marco Ciro
Publikováno v:
Cancer Research. 69:8491-8498
The E2F and MYC transcription factors are critical regulators of cell proliferation and contribute to the development of human cancers. Here, we report on the identification of a novel E2F target gene, ATAD2, the predicted protein product of which co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb3ded71c660210e57568c15053cd81
https://doi.org/10.1158/0008-5472.can-09-2131
https://doi.org/10.1158/0008-5472.can-09-2131
Autor:
Garnett Kelsoe, Fraser McBlane, Lucy Trombley, Vernon E. Walker, Barry A. Finette, Terri L. Messier, Brien McGonagle, Lindsay G. Cowell, J. Patrick O'Neill, Janet M. Murray, Jami Rivers
Publikováno v:
The Journal of Immunology. 177:5393-5404
V(D)J recombinase mediates rearrangements at immune loci and cryptic recombination signal sequences (cRSS), resulting in a variety of genomic rearrangements in normal lymphocytes and leukemic cells from children and adults. The frequency at which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e5f2ba6c2ccbc7e01033388ed0e3a78
https://doi.org/10.4049/jimmunol.177.8.5393
https://doi.org/10.4049/jimmunol.177.8.5393
Autor:
Fraser McBlane, Bertrand Montpellier, Jean-Marc Navarro, Trang Le, Katrina Vanura, Bertrand Nadel, Rodrig Marculescu, Sandrine Roulland, Ulrich Jäger
Publikováno v:
DNA Repair
DNA Repair, 2006, 5 (9-10), pp.1246-58. ⟨10.1016/j.dnarep.2006.05.015⟩
DNA Repair, Elsevier, 2006, 5 (9-10), pp.1246-58. ⟨10.1016/j.dnarep.2006.05.015⟩
DNA Repair, 2006, 5 (9-10), pp.1246-58. ⟨10.1016/j.dnarep.2006.05.015⟩
DNA Repair, Elsevier, 2006, 5 (9-10), pp.1246-58. ⟨10.1016/j.dnarep.2006.05.015⟩
A large number of lymphoid malignancies is characterized by specific chromosomal translocations, which are closely linked to the initial steps of pathogenesis. The hallmark of these translocations is the ectopic activation of a silent proto-oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd7ac4b37b05df5edd6593e814ee935
https://doi.org/10.1016/j.dnarep.2006.05.015
https://doi.org/10.1016/j.dnarep.2006.05.015
Autor:
Christina A. Cuomo, J. Fraser McBlane, Dik C. van Gent, Charles Romeo, Martin Gellert, Marjorie A. Oettinger, Dale A. Ramsden
Publikováno v:
Cell. 83(3):387-395
Formation of double-strand breaks at recombination signal sequences is an early step in V(D)J recombination. Here we show that purified RAG1 and RAG2 proteins are sufficient to carry out this reaction. The cleavage reaction can be divided into two di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f95f2ff6860241bd613d9c6a1c6032