Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Fraser M. Rogerson"'
Publikováno v:
The European physical journal. E, Soft matter. 40(8)
A key event in arthritis pathogenesis is the degradation of aggrecan, the major component in articular cartilage. In this work, we investigate the effects of stimulated aggrecanolysis on the morphological and nanomechanical properties of cartilage ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db733eca8f6960f0caa544731794996
https://pubmed.ncbi.nlm.nih.gov/28803430
https://pubmed.ncbi.nlm.nih.gov/28803430
Publikováno v:
The FASEB Journal. 28:4200-4210
The mineralocorticoid receptor (MR) is unique in responding to 2 physiological ligands: aldosterone and cortisol. In epithelial tissues, aldosterone selectivity is determined by the activity of 11β-hydroxysteroid dehydrogenase type 2. In other tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d1485a5775f9222abc3f8f0ccb6f5a
https://doi.org/10.1096/fj.13-242479
https://doi.org/10.1096/fj.13-242479
Autor:
Fraser M. Rogerson, Suzanne B. Golub, Heather Stanton, Christopher B. Little, Amanda J. Fosang
Publikováno v:
Nature Protocols. 6:388-404
Proteolysis of the cartilage proteoglycan aggrecan is a feature of arthritis. We present a method for analyzing aggrecanolysis in in vitro cultures of 3-week-old mouse femoral head cartilage based on traditional methods developed for large animal spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb6f1e2aa0062af5a3f6deee43686d6
https://doi.org/10.1038/nprot.2010.179
https://doi.org/10.1038/nprot.2010.179
Autor:
Fraser M Rogerson
Publikováno v:
Therapy. 7:579-582
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9f4e09a382b33ab7c88259594336f6e
https://doi.org/10.2217/thy.10.68
https://doi.org/10.2217/thy.10.68
Publikováno v:
Journal of Biological Chemistry. 282:8632-8640
In the mouse, proteolysis in the aggrecan interglobular domain is driven by ADAMTS-5, and mice deficient in ADAMTS-5 catalytic activity are protected against aggrecan loss and cartilage damage in experimental models of arthritis. Here we show that de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3ec2fdc1eecfa0f348476e8eb5ac89
https://doi.org/10.1074/jbc.m605750200
https://doi.org/10.1074/jbc.m605750200
Autor:
Stephanie J. Gauci, Suzanne B. Golub, Heather Stanton, Paul Holden, Shireen R. Lamandé, Richard Wilson, Amanda J. Fosang, Hansen J. Kosasih, Fraser M. Rogerson, Vincenzo C. Russo
The metalloproteinase ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin motifs) degrades aggrecan, a proteoglycan essential for cartilage structure and function. ADAMTS-5 is the major aggrecanase in mouse cartilage, and is also likely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7065bee6a1583a1bf5996127e8e48e5
https://europepmc.org/articles/PMC4751368/
https://europepmc.org/articles/PMC4751368/
Publikováno v:
Trends in Endocrinology & Metabolism. 15:296-299
Insights into the molecular basis of glucocorticoid action have been obtained from the analysis of cortisol resistance. The glucocorticoid receptor (GR) in both New World primates and guinea pigs has a decreased affinity, in vivo, for cortisol; this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670955290304aca3326a86f95c8305af
https://doi.org/10.1016/j.tem.2004.07.001
https://doi.org/10.1016/j.tem.2004.07.001
Publikováno v:
Molecular and Cellular Endocrinology. 217:203-212
The isolation of aldosterone 50 years ago was a critical first step in elucidating the mechanism by which corticosteroids regulate electrolyte homeostasis. The broad principles of this mechanism involving an intracellular receptor acting on specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e7e7e40ae740f87976c3cadf381102
https://doi.org/10.1016/j.mce.2003.10.021
https://doi.org/10.1016/j.mce.2003.10.021
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 85:389-396
The molecular mechanisms by which aldosterone regulates epithelial sodium transport in the distal colon and the distal nephron remain to be fully elucidated. Aldosterone acts via the mineralocorticoid receptor (MR) to induce the expression of genes w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c3182ccdd889cfe2cc62382badd74a
https://doi.org/10.1016/s0960-0760(03)00200-0
https://doi.org/10.1016/s0960-0760(03)00200-0
Autor:
Fraser M. Rogerson, Peter J. Fuller
Publikováno v:
Molecular and Cellular Endocrinology. 200:45-55
The potential for interaction between the N-terminal domain and the C-terminal region (hinge and ligand-binding domain) of the mineralocorticoid receptor (MR) was examined using the mammalian-2-hybrid assay. The MR C-terminal region was fused to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83bc5487ee36951731815f6f7ac36bd
https://doi.org/10.1016/s0303-7207(02)00413-6
https://doi.org/10.1016/s0303-7207(02)00413-6