Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Fraser J. Wilkes"'
Autor:
Jonathon M Tinsley, Rebecca J Fairclough, Richard Storer, Fraser J Wilkes, Allyson C Potter, Sarah E Squire, Dave S Powell, Anna Cozzoli, Roberta F Capogrosso, Adam Lambert, Francis X Wilson, Stephen P Wren, Annamaria De Luca, Kay E Davies
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19189 (2011)
BACKGROUND:Duchenne muscular dystrophy (DMD) is a lethal, progressive muscle wasting disease caused by a loss of sarcolemmal bound dystrophin, which results in the death of the muscle fibers leading to the gradual depletion of skeletal muscle. There
Externí odkaz:
https://doaj.org/article/f88f93f8b2a047659005a47423959f5b
Autor:
Carole Eliane Andree Maillol, Richard Storer, Severine Danielle Poignant, Peter David Johnson, Renate van Well, Stephen Paul Wren, Jonathon M. Tinsley, Adam G. Lambert, Gary Nugent, Francis Xavier Wilson, Fraser J. Wilkes, Colin Richard Dorgan, Richard Vickers, Graham Michael Wynne, Cristina Lecci, Richard Joseph Pye, Olivier De Moor, Paul Damien Price
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4828-4831
Families of 2-arylbenzotriazoles and 2-arylindazoles that show positive effects in screens predictive of endogenous utrophin upregulation have been identified. Synthesis and structure-activity relationships are described leading to compounds with att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88eb43eff53eb7246db535b17fe5fdd3
https://doi.org/10.1016/j.bmcl.2011.06.047
https://doi.org/10.1016/j.bmcl.2011.06.047
Autor:
Severine Danielle Poignant, Fraser J. Wilkes, Kay E. Davies, Adam G. Lambert, J Vile, P J Middleton, Francis Xavier Wilson, Peter David Johnson, Stephen Paul Wren, Carole Eliane Andree Maillol, Richard Storer, Chancellor, D Lawrence, Collin Richard Dorgan, Richard Vickers, Graham Michael Wynne, A Potter, Cristina Lecci, Paul Damien Price, Gary Nugent, O De Moor, Richard Joseph Pye, R van Well, Jonathon M. Tinsley
Publikováno v:
Journal of Medicinal Chemistry. 54:3241-3250
A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold considerable promise as a potential t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7d5e973d1a9516da52e0847a018b37
https://doi.org/10.1021/jm200135z
https://doi.org/10.1021/jm200135z
Autor:
Mimoun Azzouz, Umrao R. Monani, G. Scott Ralph, Fraser J. Wilkes, Debbie C.P. Lee, Susan M. Kingsman, Lucy E. Walmsley, Arthur H.M. Burghes, Kyriacos A. Mitrophanous, Nicholas D. Mazarakis, Thanh Le
Publikováno v:
Journal of Clinical Investigation. 114:1726-1731
Spinal muscular atrophy (SMA) is a frequent recessive autosomal disorder. It is caused by mutations or deletion of the telomeric copy of the survival motor neuron (SMN) gene, leading to depletion in SMN protein levels. The treatment rationale for SMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8203d3554a255d105539071a8bc9d16f
https://doi.org/10.1172/jci22922
https://doi.org/10.1172/jci22922
Autor:
Emma E. Carter, Nicholas D. Mazarakis, Fiona Margaret Ellard, Anna L. Olsen, Robert D. Barber, Karen L. O'Malley, Dilair F. Baban, Alan J. Kingsman, Jonathan Rohll, Kyriacos Mitrophanous, Mimoun Azzouz, Fraser J. Wilkes, Susan Mary Kingsman
Publikováno v:
Human Molecular Genetics. 10:2109-2121
In this report it is demonstrated for the first time that rabies-G envelope of the rabies virus is sufficient to confer retrograde axonal transport to a heterologous virus/vector. After delivery of rabies-G pseudotyped equine infectious anaemia virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec8c35ae2e45b61c23bda27a07a38f7
https://doi.org/10.1093/hmg/10.19.2109
https://doi.org/10.1093/hmg/10.19.2109
Autor:
Graeme Horne, Fraser J. Wilkes, Richard Storer, Francis Xavier Wilson, Lindsay Fowler, Louise Czemerys, Renate van Well, Colin Richard Dorgan, Jon Tinsley
Publikováno v:
Alzheimer's & Dementia. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce8d209a2b02f9e65f54c615759dd016
https://doi.org/10.1016/j.jalz.2012.05.1554
https://doi.org/10.1016/j.jalz.2012.05.1554
Autor:
Graeme Horne, Francis Xavier Wilson, Sihong Chen, Jon Tinsley, Renate van Well, Fraser J. Wilkes
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c261505f2d4a5bceee13c41ffa101a1
https://doi.org/10.1016/j.jalz.2011.05.1609
https://doi.org/10.1016/j.jalz.2011.05.1609
Autor:
Sarah E. Squire, Fraser J. Wilkes, R.J. Fairclough, D Powell, Richard Storer, Adam G. Lambert, Anna Cozzoli, A Potter, Roberta Francesca Capogrosso, Stephen Paul Wren, Francis Xavier Wilson, Jonathon M. Tinsley, Annamaria De Luca, Kay E. Davies
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 5, p e19189 (2011)
PLoS ONE, Vol 6, Iss 5, p e19189 (2011)
BACKGROUND: Duchenne muscular dystrophy (DMD) is a lethal, progressive muscle wasting disease caused by a loss of sarcolemmal bound dystrophin, which results in the death of the muscle fibers leading to the gradual depletion of skeletal muscle. There
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4318dbbb8a108077dbf3477bd8a8b0
http://ora.ox.ac.uk/objects/uuid:ed989d83-882f-490c-b5ff-d650858e7db3
http://ora.ox.ac.uk/objects/uuid:ed989d83-882f-490c-b5ff-d650858e7db3
Autor:
K A Mitrophanous, Pippa A Radcliffe, E J Custard, G L Beard, Fraser J. Wilkes, Susan M. Kingsman, C J M Sion
Publikováno v:
Gene therapy. 15(4)
Effective gene therapy for haemophilia A necessitates a vector system that is not subject to a pre-existing immune response, has adequate coding capacity, gives long-term expression and preferably can target non-dividing cells. Vector systems based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea4b1ceaae5dafa7d58601c49305673
https://pubmed.ncbi.nlm.nih.gov/18046428
https://pubmed.ncbi.nlm.nih.gov/18046428
Autor:
Nicholas D. Mazarakis, Susan M. Kingsman, Lucy E. Walmsley, Kyriacos A. Mitrophanous, Liang-Fong Wong, Mimoun Azzouz, Zoe Askham, Fraser J. Wilkes
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 9(1)
We have developed a non-primate-based lentiviral vector based on the equine infectious anemia virus (EIAV) for efficient gene transfer to the central and peripheral nervous systems. Previously we have demonstrated that pseudotyping lentiviral vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee08fe95ff25fb8f9dcd00eec52c3627
https://pubmed.ncbi.nlm.nih.gov/14741783
https://pubmed.ncbi.nlm.nih.gov/14741783