Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Fraser Hunt"'
Autor:
Stuart Thomas Onions, Harry Finch, Christopher Sleigh, Damien Crepin, John Murray, Euan A. F. Fordyce, John King-Underwood, S. Fraser Hunt, Guillaume F. Parra
Publikováno v:
MedChemComm
Atropisomeric drug substances are known to have different biological properties. Compounds containing the N-benzoylbenzazepine motif have been shown to exhibit energetically restricted rotation around the Ar(CO)N axis. Herein we report, for the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff2db5aef776b2b98989d6317b24b30
https://doi.org/10.1039/c8md00033f
https://doi.org/10.1039/c8md00033f
Autor:
S. Fraser Hunt, Peter Strong, John King-Underwood, Matthew Coates, Jennifer A. Stockwell, Vladimir Sherbukhin, Daniel W. Brookes, Stuart Thomas Onions, Claire Lise-Ciana, Kazuhiro Ito, John Murray, Euan A. F. Fordyce, Guillaume F. Parra, Garth Rapeport, Jennifer C. Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2201-2206
The development of novel non-nucleoside inhibitors of the RSV polymerase complex is of significant clinical interest. Compounds derived from the benzothienoazepine core, such as AZ-27, are potent inhibitors of RSV viruses of the A-subgroup, but are o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b34f57b112d8107bbe874f80804538
https://doi.org/10.1016/j.bmcl.2017.03.053
https://doi.org/10.1016/j.bmcl.2017.03.053
Autor:
Euan A. F. Fordyce, S. Fraser Hunt, Damien Crepin, Stuart T. Onions, Guillaume F. Parra, Chris J. Sleigh, John King-Underwood, Harry Finch, John Murray
Publikováno v:
MedChemComm. 9(4)
Atropisomeric drug substances are known to have different biological properties. Compounds containing the N-benzoylbenzazepine motif have been shown to exhibit energetically restricted rotation around the Ar(CO)N axis. Herein we report, for the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32863273823999a86e63c739ea2d07f0
https://pubmed.ncbi.nlm.nih.gov/30108949
https://pubmed.ncbi.nlm.nih.gov/30108949
Autor:
John P. DeVincenzo, Young-In Kim, Guillaume F. Parra, Daniel W. Brookes, Euan A. F. Fordyce, Claire-Lise Ciana, Vladimir Sherbukhin, Kazuhiro Ito, Pete Strong, Jennifer A. Stockwell, Garth Rapeport, Matthew Coates, Peter John Murray, S. Fraser Hunt, Elizabeth A. Meals, Lindsey Cass, Jennifer C. Thomas, Thomas Colley, Stuart Thomas Onions, Lauren Anderson-Dring, Heather Allen
Publikováno v:
Antimicrobial Agents and Chemotherapy
Although respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants and young children, attempts to develop an effective therapy have so far proved unsuccessful. Here we report the preclinical profiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa54caa466846b5a19adf151dd2fca7
http://europepmc.org/articles/PMC5571287
http://europepmc.org/articles/PMC5571287
Autor:
David Donald, Lilian Alcaraz, Daniel J. Warner, Nicholas Kindon, Andrew Bailey, Michael J. Stocks, Garry Pairaudeau, Keith Bowers, Jill Theaker, Fraser Hunt, Helen Edwards
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7458-7461
The optimisation of a new series of high potency muscarinic M3 antagonists, derived from high throughput screening library hit is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9303d8fd2483e822cacf764e13f739
https://doi.org/10.1016/j.bmcl.2010.10.016
https://doi.org/10.1016/j.bmcl.2010.10.016
Autor:
Simon Barber, John Unitt, David Laughton, Fraser Hunt, Sarah King, Bob Thong, Andrew Baxter, Denise Grice, Alastair J. H. Brown, Garry Pairaudeau, Hitesh J. Sanganee, Richard J. Weaver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1143-1147
A novel series of small molecule C5a antagonists is reported. In particular, in vitro metabolic studies and solution based combinatorial synthesis are demonstrated as useful tools for the rapid identification of antagonists with low in vitro clearanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c845beadbca4f62c0827d86827abdd7
https://doi.org/10.1016/j.bmcl.2008.12.104
https://doi.org/10.1016/j.bmcl.2008.12.104
Autor:
Fordyce, Euan A. F., Fraser Hunt, S., Crepin, Damien, Onions, Stuart T., Parra, Guillaume F., Sleigh, Chris J., King-Underwood, John, Finch, Harry, Murray, John
Publikováno v:
MedChemComm; Mar2018, Vol. 9 Issue 3, p583-589, 7p
Autor:
Mark I Christie, Roger Bonnert, Mark Ebden, Peter Cage, Iain Walters, Fraser Hunt, Shirley Lewis, Caroline Austin, Caroline Grahames, David J. Nicholls, Rupert P. Austin, Robert Jewell, Steven Hill, Iain J. Martin, David J. Robinson, Stuart Gardiner
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
The CXCR2 SAR of a series of bicyclic antagonists such as the 2-aminothiazolo[4,5-d]pyrimidine 3b was investigated by systematic variation of the fused pyrimidine-based heterocyclic cores. Replacement of the aminothiazole ring with a 2-thiazolone alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac2ff5b3bea99bb7e120f06b772d80c
https://pubmed.ncbi.nlm.nih.gov/18240390
https://pubmed.ncbi.nlm.nih.gov/18240390
Autor:
Clare Dixon, David J. Robinson, Mark I Christie, Steven Hill, Jadeen Christie, Ian Martin, Rupert P. Austin, Robert Jewell, Paul Willis, Peter Cage, Caroline Austin, Fraser Hunt, Roger Bonnert
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(10)
As part of a Lead Optimisation programme to identify small molecule antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22c6b4e0fd918761df7048c4a39a493
https://pubmed.ncbi.nlm.nih.gov/17382543
https://pubmed.ncbi.nlm.nih.gov/17382543
Autor:
Kevin J. Edwards, Jorge Rolland Calvo, Berta Martínez Silva, Rodrigo de Balbín Behrmann, Ignacio Montero Ruiz, Charles-Tanguy Le Roux, Manuel Alberto Fernández Götz, Emili Junyent, Xosé-Lois Armada Pita, Brendan O’Connor, Fraser Hunter, Teresa Chapa Brunet, Isabel Izquierdo Peraile
Publikováno v:
Trabajos de Prehistoria, Vol 65, Iss 1, Pp 181-200 (2008)
Externí odkaz:
https://doaj.org/article/895ef61b91014d31a0625e55fefae470