Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Fraser Glickman"'
Autor:
Aparna Talekar, Antonello Pessi, Fraser Glickman, Uttara Sengupta, Thomas Briese, Michael A Whitt, Cyrille Mathieu, Branka Horvat, Anne Moscona, Matteo Porotto
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e30538 (2012)
Emerging viruses including Nipah, Hendra, Lujo, and Junin viruses have enormous potential to spread rapidly. Nipah virus, after emerging as a zoonosis, has also evolved the capacity for human-to-human transmission. Most of the diseases caused by thes
Externí odkaz:
https://doaj.org/article/307493a1871c441a8f21c1f93bd2bed2
Autor:
Christopher S. Krumm, Renée S. Landzberg, Lavoisier Ramos-Espiritu, Carolina Adura, Xu Liu, Mariana Acuna, Yang Xie, Xu Xu, Matthew C. Tillman, Yingxia Li, J. Fraser Glickman, Eric A. Ortlund, John D. Ginn, David E. Cohen
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101832- (2023)
Objective: Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C-terminal lipid-sensing steroidogenic acute regulatory transfer-related (START) domain, wh
Externí odkaz:
https://doaj.org/article/8de5909740c140df964ea243b24a5e5d
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little efficacy on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2e6eadd89b35c3fbc11103d986522f
https://doi.org/10.1158/2159-8290.c.6549037.v1
https://doi.org/10.1158/2159-8290.c.6549037.v1
Autor:
Ranjit S. Bindra, Simon N. Powell, J. Fraser Glickman, Harriet M. Kluger, Maria Jasin, Jennifer A. Wilshire, Petrus J. Hendrikx, Jeanne Chiaravalli, Ranjini K. Sundaram, Ahmed F. Salem, David Shahbazian, Antonio N. Luz, Robert Delsite, Alexander G. Goglia
Results for each of the 16 identified hits in the panel of IR foci formation assays, and additional clonogenic survival data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2413ea7aafb134ab76274203272711
https://doi.org/10.1158/1535-7163.22503628
https://doi.org/10.1158/1535-7163.22503628
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
Supplementary Figure 1 - 6 and Supplementary Tables 1, 2, and 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b902995a0b627ef4461c460e313fed
https://doi.org/10.1158/2159-8290.22539256
https://doi.org/10.1158/2159-8290.22539256
Autor:
Ranjit S. Bindra, Simon N. Powell, J. Fraser Glickman, Harriet M. Kluger, Maria Jasin, Jennifer A. Wilshire, Petrus J. Hendrikx, Jeanne Chiaravalli, Ranjini K. Sundaram, Ahmed F. Salem, David Shahbazian, Antonio N. Luz, Robert Delsite, Alexander G. Goglia
HR and mNHEJ results of the high-throughput screen presented as a 2D RADaR plot.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affcfc049296b668007e6b53f1e5e578
https://doi.org/10.1158/1535-7163.22503646.v1
https://doi.org/10.1158/1535-7163.22503646.v1
Autor:
Ranjit S. Bindra, Simon N. Powell, J. Fraser Glickman, Harriet M. Kluger, Maria Jasin, Jennifer A. Wilshire, Petrus J. Hendrikx, Jeanne Chiaravalli, Ranjini K. Sundaram, Ahmed F. Salem, David Shahbazian, Antonio N. Luz, Robert Delsite, Alexander G. Goglia
Additional data for hits from the primary screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862ddc972d914ec15877873254bb58fd
https://doi.org/10.1158/1535-7163.22503625
https://doi.org/10.1158/1535-7163.22503625
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
List of compounds in the primary screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca221efe677664568327262bb0935e7f
https://doi.org/10.1158/2159-8290.22539253
https://doi.org/10.1158/2159-8290.22539253
Autor:
Ranjit S. Bindra, Simon N. Powell, J. Fraser Glickman, Harriet M. Kluger, Maria Jasin, Jennifer A. Wilshire, Petrus J. Hendrikx, Jeanne Chiaravalli, Ranjini K. Sundaram, Ahmed F. Salem, David Shahbazian, Antonio N. Luz, Robert Delsite, Alexander G. Goglia
Additional cell-based DSB repair assay optimization studies in preparation for high-throughput screening.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f6558e3af8443e735e7eadca176f48
https://doi.org/10.1158/1535-7163.22503649
https://doi.org/10.1158/1535-7163.22503649
Autor:
Ranjit S. Bindra, Simon N. Powell, J. Fraser Glickman, Harriet M. Kluger, Maria Jasin, Jennifer A. Wilshire, Petrus J. Hendrikx, Jeanne Chiaravalli, Ranjini K. Sundaram, Ahmed F. Salem, David Shahbazian, Antonio N. Luz, Robert Delsite, Alexander G. Goglia
Counter-screen to rule out small molecule hits which may non-specifically inhibit fluorescence leading to false positive results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363a45bd2ba127a23d0d20bd8664920e
https://doi.org/10.1158/1535-7163.22503640.v1
https://doi.org/10.1158/1535-7163.22503640.v1