Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Fraser Glickman"'
Autor:
Aparna Talekar, Antonello Pessi, Fraser Glickman, Uttara Sengupta, Thomas Briese, Michael A Whitt, Cyrille Mathieu, Branka Horvat, Anne Moscona, Matteo Porotto
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e30538 (2012)
Emerging viruses including Nipah, Hendra, Lujo, and Junin viruses have enormous potential to spread rapidly. Nipah virus, after emerging as a zoonosis, has also evolved the capacity for human-to-human transmission. Most of the diseases caused by thes
Externí odkaz:
https://doaj.org/article/307493a1871c441a8f21c1f93bd2bed2
Autor:
Christopher S. Krumm, Renée S. Landzberg, Lavoisier Ramos-Espiritu, Carolina Adura, Xu Liu, Mariana Acuna, Yang Xie, Xu Xu, Matthew C. Tillman, Yingxia Li, J. Fraser Glickman, Eric A. Ortlund, John D. Ginn, David E. Cohen
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101832- (2023)
Objective: Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C-terminal lipid-sensing steroidogenic acute regulatory transfer-related (START) domain, wh
Externí odkaz:
https://doaj.org/article/8de5909740c140df964ea243b24a5e5d
Autor:
Richard C Lavin, Calvin Johnson, Yong-Mo Ahn, Kyle M Kremiller, Matthew Sherwood, Jimmy S Patel, Yan Pan, Riccardo Russo, Nathan J MacGilvary, David Giacalone, Yuzo L Kevorkian, Matthew D Zimmerman, J Fraser Glickman, Joel S Freundlich, Shumin Tan
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001355 (2021)
Sensing and response to environmental cues, such as pH and chloride (Cl-), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have identified compoun
Externí odkaz:
https://doaj.org/article/e8e92b4c6c2a4557821d17bd95672572
Autor:
Gerard Minuesa, Steven K. Albanese, Wei Xie, Yaniv Kazansky, Daniel Worroll, Arthur Chow, Alexandra Schurer, Sun-Mi Park, Christina Z. Rotsides, James Taggart, Andrea Rizzi, Levi N. Naden, Timothy Chou, Saroj Gourkanti, Daniel Cappel, Maria C. Passarelli, Lauren Fairchild, Carolina Adura, J. Fraser Glickman, Jessica Schulman, Christopher Famulare, Minal Patel, Joseph K. Eibl, Gregory M. Ross, Shibani Bhattacharya, Derek S. Tan, Christina S. Leslie, Thijs Beuming, Dinshaw J. Patel, Yehuda Goldgur, John D. Chodera, Michael G. Kharas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.
Externí odkaz:
https://doaj.org/article/0841d30974ee49439a137cb5c41e499b
Autor:
Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, Thomas Tuschl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in inte
Externí odkaz:
https://doaj.org/article/6f06ae155ca2436dab39b0d693daf384
Autor:
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor a
Externí odkaz:
https://doaj.org/article/2885ccbed5fa465f9f9e037a1d7866c1
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little efficacy on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2e6eadd89b35c3fbc11103d986522f
https://doi.org/10.1158/2159-8290.c.6549037.v1
https://doi.org/10.1158/2159-8290.c.6549037.v1
Autor:
Ranjit S. Bindra, Simon N. Powell, J. Fraser Glickman, Harriet M. Kluger, Maria Jasin, Jennifer A. Wilshire, Petrus J. Hendrikx, Jeanne Chiaravalli, Ranjini K. Sundaram, Ahmed F. Salem, David Shahbazian, Antonio N. Luz, Robert Delsite, Alexander G. Goglia
Results for each of the 16 identified hits in the panel of IR foci formation assays, and additional clonogenic survival data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2413ea7aafb134ab76274203272711
https://doi.org/10.1158/1535-7163.22503628
https://doi.org/10.1158/1535-7163.22503628
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
Supplementary Figure 1 - 6 and Supplementary Tables 1, 2, and 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b902995a0b627ef4461c460e313fed
https://doi.org/10.1158/2159-8290.22539256
https://doi.org/10.1158/2159-8290.22539256
Autor:
Ranjit S. Bindra, Simon N. Powell, J. Fraser Glickman, Harriet M. Kluger, Maria Jasin, Jennifer A. Wilshire, Petrus J. Hendrikx, Jeanne Chiaravalli, Ranjini K. Sundaram, Ahmed F. Salem, David Shahbazian, Antonio N. Luz, Robert Delsite, Alexander G. Goglia
HR and mNHEJ results of the high-throughput screen presented as a 2D RADaR plot.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affcfc049296b668007e6b53f1e5e578
https://doi.org/10.1158/1535-7163.22503646.v1
https://doi.org/10.1158/1535-7163.22503646.v1