Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Fraser G. Edgar"'
Autor:
Vladimir Shalgunov, Mengfei Xiong, Elina T. L’Estrade, Nakul R. Raval, Ida V. Andersen, Fraser G. Edgar, Nikolaj R. Speth, Simone L. Baerentzen, Hanne D. Hansen, Lene L. Donovan, Arafat Nasser, Siv T. Peitersen, Andreas Kjaer, Gitte M. Knudsen, Stina Syvänen, Mikael Palner, Matthias M. Herth
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Background Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessib
Externí odkaz:
https://doaj.org/article/abd4cf9642dc46f89d08c15d1cabc529
Autor:
Elina Tampio L’Estrade, Fraser G. Edgar, Mengfei Xiong, Vladimir Shalgunov, Simone L. Baerentzen, Maria Erlandsson, Tomas G. Ohlsson, Mikael Palner, Gitte M. Knudsen, Matthias M. Herth
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 7344-7353 (2019)
Externí odkaz:
https://doaj.org/article/a2f7493d2aa241d4aaf74d2a67c30505
Autor:
Simone Bærentzen, Agata Casado-Sainz, Denise Lange, Vladimir Shalgunov, Isabel Martinez Tejada, Mengfei Xiong, Elina T. L’Estrade, Fraser G. Edgar, Hedok Lee, Matthias M. Herth, Mikael Palner
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Chemogenetic studies with the ligand clozapine N-oxide (CNO) are predicated upon the assumption that CNO is devoid of actions at natural neuroreceptors. However, recent evidence shows that CNO may be converted back to clozapine (CLZ) in vivo, which c
Externí odkaz:
https://doaj.org/article/551a491d81c843848396af6bd5fc1577
Autor:
Vladimir Shalgunov, Ida Nymann Petersen, Matthias M. Herth, Tomas Ohlsson, Fraser G. Edgar, Elina T. L’Estrade, Maria Erlandsson, Balázs Volk, Szabolcs Lehel, Christian B. M. Poulie, Gitte M. Knudsen
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 326:1749-1762
In this work, a fragment-based labeling procedure was developed based on condensation reactions. Six 18F-labeled (arylpiperazinyl-butyl)oxindole derivatives were synthesized. These structures are interesting lead compounds with respect to development
Autor:
Ramesh Neelamegam, Elina T. L 'Estrade, Vladimir Shalgunov, Matthias M. Herth, Fraser G. Edgar, Agnete Dyssegaard, Jacob M. Hooker, Tomas Ohlsson, Hanne D. Hansen, Mengfei Xiong, Martin Georg Strebl-Bantillo, Maria Erlandsson, Gitte M. Knudsen, François Crestey, Szabolcs Lehel
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 63:46-55
The serotonin 7 (5-HT7 ) receptor is suggested to be involved in a broad variety of CNS disorders, but very few in vivo tools exist to study this important target. Molecular imaging with positron emission tomography (PET) would enable an in vivo char
Autor:
Simone L. Baerentzen, Tomas Ohlsson, Maria Erlandsson, Mikael Palner, Vladimir Shalgunov, Elina T. L’Estrade, Fraser G. Edgar, Balázs Volk, Mengfei Xiong, Matthias M. Herth, Gitte M. Knudsen
Publikováno v:
ACS Chemical Neuroscience. 10:3961-3968
The latest addition to the serotonin (5-HT) receptor family is the 5-HT7 receptor (5-HT7R). This receptor has gained interest as a drug target due to its involvement in various disorders such as depression or schizophrenia. There is currently no clin
Autor:
Simone L. Baerentzen, Maria Erlandsson, Vladimir Shalgunov, Mengfei Xiong, Elina T. L’Estrade, Mikael Palner, Gitte M. Knudsen, Fraser G. Edgar, Tomas Ohlsson, Matthias M. Herth
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 7344-7353 (2019)
Tampio L'Estrade, E, Edgar, F G, Xiong, M, Shalgunov, V, Baerentzen, S L, Erlandsson, M, Ohlsson, T G, Palner, M, Knudsen, G M & Herth, M M 2019, ' Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of [ 18 F]ENL30 : A Potential PET Radiotracer for the 5-HT 7 Receptor ', ACS Omega, vol. 4, no. 4, pp. 7344-7353 . https://doi.org/10.1021/acsomega.9b00394
Tampio L'Estrade, E, Edgar, F G, Xiong, M, Shalgunov, V, Baerentzen, S L, Erlandsson, M, Ohlsson, T G, Palner, M, Knudsen, G M & Herth, M M 2019, ' Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of [ 18 F]ENL30 : A Potential PET Radiotracer for the 5-HT 7 Receptor ', ACS Omega, vol. 4, no. 4, pp. 7344-7353 . https://doi.org/10.1021/acsomega.9b00394
The 5-HT 7 receptor (5-HT 7 R) is involved in a broad range of physiological conditions and disorders. Currently, there is no validated clinical positron emission tomography (PET) tracer available; however, we have recently developed a promising 11 C
Autor:
Gitte M. Knudsen, Siv Thorlund Peitersen, Mengfei Xiong, Matthias M. Herth, Lene Lundgaard Donovan, Nikolaj Speth, Andreas Kjaer, Arafat Nasser, Fraser G. Edgar, Ida Vang Andersen, Hanne D. Hansen, Mikael Palner, Vladimir Shalgunov, Simone L. Baerentzen, Nakul Ravi Raval, Stina Syvänen, Elina T. L’Estrade
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-11 (2020)
EJNMMI Research
Shalgunov, V, Xiong, M, L’Estrade, E T, Raval, N R, Andersen, I V, Edgar, F G, Speth, N R, Baerentzen, S L, Hansen, H D, Donovan, L L, Nasser, A, Peitersen, S T, Kjaer, A, Knudsen, G M, Syvänen, S, Palner, M & Herth, M M 2020, ' Blocking of efflux transporters in rats improves translational validation of brain radioligands ', EJNMMI Research, vol. 10, no. 1, 124 . https://doi.org/10.1186/s13550-020-00718-x
EJNMMI Research
Shalgunov, V, Xiong, M, L’Estrade, E T, Raval, N R, Andersen, I V, Edgar, F G, Speth, N R, Baerentzen, S L, Hansen, H D, Donovan, L L, Nasser, A, Peitersen, S T, Kjaer, A, Knudsen, G M, Syvänen, S, Palner, M & Herth, M M 2020, ' Blocking of efflux transporters in rats improves translational validation of brain radioligands ', EJNMMI Research, vol. 10, no. 1, 124 . https://doi.org/10.1186/s13550-020-00718-x
Background Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of
Autor:
Anders Ettrup, Hanne D. Hansen, Fraser G. Edgar, Jesper L. Kristensen, Gitte M. Knudsen, Sebastian Leth-Petersen, Matthias M. Herth
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 60:586-591
An agonist PET tracer is of key interest for the imaging of the 5-HT2A receptor, as exemplified by the previously reported success of [11 C]Cimbi-36. Fluorine-18 holds several advantages over carbon-11, making it the radionuclide of choice for clinic
Autor:
Elina T, L'Estrade, Maria, Erlandsson, Fraser G, Edgar, Tomas, Ohlsson, Gitte M, Knudsen, Matthias M, Herth
Publikováno v:
Neuropharmacology. 172
Since its discovery in 1993, the serotonin receptor subtype 7 (5-HT