Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Fraser G Ferens"'
Publikováno v:
eLife, Vol 11 (2022)
von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that causes a predisposition to renal clear-cell carcinoma, hemangioblastoma, pheochromocytoma, and autosomal-recessive familial polycythemia. pVHL is the substrate conferring subun
Externí odkaz:
https://doaj.org/article/f9f497551509475db5e06419e2dabacf
Autor:
Fraser G. Ferens, Cassandra C. Taber, Sarah Stuart, Mia Hubert, Daniel Tarade, Jeffrey E. Lee, Michael Ohh
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Pacak-Zhuang syndrome is caused by mutations in the EPAS1 gene, which encodes for one of the three hypoxia-inducible factor alpha (HIFα) paralogs HIF2α and is associated with defined but varied phenotypic presentations including neuroendoc
Externí odkaz:
https://doaj.org/article/ecd3feb7584042e8b24042291be7574e
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The voltage-dependent anion-selective channel (VDAC) is a porin in the mitochondrial outer membrane (MOM). Unlike bacterial porins, several mitochondrial β-barrels comprise an odd number of β-strands, as is the case for the 19-β-stranded VDAC. Pre
Externí odkaz:
https://doaj.org/article/487d3306d0aa43f3a9330dc4c8de2a82
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology, Vol 12 (2021)
The voltage-dependent anion-selective channel (VDAC) is a porin in the mitochondrial outer membrane (MOM). Unlike bacterial porins, several mitochondrial β-barrels comprise an odd number of β-strands, as is the case for the 19-β-stranded VDAC. Pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226fff4e0c2b43c86d3928356bc7f6a5
http://europepmc.org/articles/PMC8485043
http://europepmc.org/articles/PMC8485043
Publikováno v:
Biophysical Journal. 116:847-859
The oligomeric organization of the voltage-dependent anion-selective channel (VDAC) and its interactions with hexokinase play integral roles in mitochondrially mediated apoptotic signaling. Various small to large assemblies of VDAC are observed in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6888bef0e7b3c13c9555379034323d
https://doi.org/10.1016/j.bpj.2019.01.031
https://doi.org/10.1016/j.bpj.2019.01.031
Autor:
William A.T. Summers, Deborah A. Court, Fraser G. Ferens, Oleg V. Krokhin, Victor Spicer, Anna Motnenko
Publikováno v:
Biochemistry and Cell Biology. 95:318-327
Mitochondrial porin, the voltage-dependent anion channel, plays an important role in metabolism and other cellular functions within eukaryotic cells. To further the understanding of porin structure and function, Neurospora crassa wild-type porin was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15625c8c9a9a9378dec7cd0c3d0531aa
https://doi.org/10.1139/bcb-2016-0166
https://doi.org/10.1139/bcb-2016-0166
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:1350-1361
A novel feature of the voltage-dependent anion channel (VDAC, mitochondrial porin), is the barrel, comprising an odd number of β-strands and closed by parallel strands. Recent research has focused on the N-terminal segment, which in the available st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8059ce74dab1be3cc485f655845bfaba
https://doi.org/10.1016/j.bbamem.2016.03.017
https://doi.org/10.1016/j.bbamem.2016.03.017
Autor:
Mary Hernando, Andrew J. Nieuwkoop, Fraser G. Ferens, George L. Orriss, Jörg Stetefeld, Shixing Lei, Jacqueline Perodeau, Trushar R. Patel, Joe D. O'Neil
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1862:183191
Protein dynamics at atomic resolution can provide deep insights into the biological activities of proteins and enzymes but they can also make structure and dynamics studies challenging. Despite their well-known biological and pharmaceutical importanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353dacd062aa070a19a39d8761a032b3
https://doi.org/10.1016/j.bbamem.2020.183191
https://doi.org/10.1016/j.bbamem.2020.183191