Výsledky vyhledávání - "Fraser D. Brown"

An Effector Domain Mutant of Arf6 Implicates Phospholipase D in Endosomal Membrane Recycling

Autor: Julie G. Donaldson, Olivera A. Jovanovic, Fraser D. Brown

Publikováno v: Molecular Biology of the Cell. 17:327-335

In this study, we investigated the role of phospholipase D (PLD) in mediating Arf6 function in cells. Expression of Arf6 mutants that are defective in activating PLD, Arf6N48R and Arf6N48I, inhibited membrane recycling to the plasma membrane (PM), re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ea2d37c695448a0451581bb6ea0c7c
https://doi.org/10.1091/mbc.e05-06-0523

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Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic

Autor: Fraser D. Brown, Tamas Balla, Andrew L. Rozelle, Julie G. Donaldson, Helen L. Yin

Publikováno v: The Journal of Cell Biology

ADP-ribosylation factor (Arf) 6 regulates the movement of membrane between the plasma membrane (PM) and a nonclathrin-derived endosomal compartment and activates phosphatidylinositol 4-phosphate 5-kinase (PIP 5-kinase), an enzyme that generates phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b55c337d0c991dc9c0f096b9a48009
http://europepmc.org/articles/PMC2196179

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Acaps Are Arf6 Gtpase-Activating Proteins That Function in the Cell Periphery

Autor: Jianlan Sun, Koichi Miura, Fraser D. Brown, Julie G. Donaldson, Zhongzhen Nie, Victor W. Hsu, Letizia Foroni, Paul A. Randazzo, Trevor R. Jackson

Publikováno v: The Journal of Cell Biology

The GTP-binding protein ADP-ribosylation factor 6 (Arf6) regulates endosomal membrane trafficking and the actin cytoskeleton in the cell periphery. GTPase-activating proteins (GAPs) are critical regulators of Arf function, controlling the return of A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ee33bad44bc0081b32df249c324f21
https://doi.org/10.1083/jcb.151.3.627

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Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains

Autor: Julie G. Donaldson, Lee Ann Cohen, Tamas Balla, Fraser D. Brown, Péter Várnai, Akira Honda

Publikováno v: Molecular biology of the cell. 18(6)

ARNO is a soluble guanine nucleotide exchange factor (GEF) for the Arf family of GTPases. Although in biochemical assays ARNO prefers Arf1 over Arf6 as a substrate, its localization in cells at the plasma membrane (PM) suggests an interaction with Ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e29644acf1678ca2323ad3ca0110789
https://pubmed.ncbi.nlm.nih.gov/17409355

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Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules

Autor: Victoria C. Foletta, Fraser D. Brown, W. Scott Young

The Rho GTPase family of intracellular molecular switches control multiple cellular functions via the regulation of the actin cytoskeleton. Increasing evidence implicates a critical involvement of these molecules in the nervous system, particularly d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5067c60b8b2feba51b7b60f5609f6b2e
https://zenodo.org/record/1259925

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