Protocol for a phase 3, randomised, active-control study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients requiring coagulation factor replacement: the LEX-211 (FARES-II) trial

Autor: Éric Dumont, Lusine Abrahamyan, Stuart Mccluskey, Angela Jerath, Humara Poonawala, Andrew Stevens, Jeannie Callum, Alan Tinmouth, Daniel Wong, Gianluigi Bisleri, Tarit Saha, David Mazer, Hilary Grocott, Jane Yang, Jeff Kinney, Yoan Lamarche, Damon Scales, George Tomlinson, Fuad Moussa, Andrew Shih, Michelle Zeller, Melanie Tokessy, Keyvan Karkouti, Vivek Rao, Summer Syed, Lilia Kaustov, Sophia Wong, Lani Lieberman, Kamrouz Ghadimi, Philippe Demers, Penny Johnson, Jerrold H Levy, Justyna Bartoszko, Miki Peer, Michael Law, Michelle Wong, Mackenzie Quantz, Antoine Rochon, Fraser Rubens, Shagun Jain, Yulia Lin, Katerina Pavenski, Deep Grewal, Deborah DuMerton, Darrin Payne, Saba Ansari, Robert Mayer, Rebecca Randall, Aftab Malik, Bethany Smethurst, Laura Molnar, Angela Sirosky-Yanyk, Mark Peterson, Christopher Harle, Etienne Couture, Diem Tran, Cristina Solomon, Sigurd Knaub, Kenichi A Tanaka, Blaine Achen, Sukhpal Brar, Matthew Coley, Dana Devine, Alana Flexman, Camila Machado de Souza, Maria Rosal Martins, Terri Sun, Rob Tanzola, Mathew Yan, Raffael Zamper, Jo Carrol, Nishanthi Liyanage, Simryn Selby, Reezanoor Kabir, Shelley Oliver, Alioska Escorcia, Susana Medic, Michelle Mozel, Ramanjot Kaur, Kelly Bizovie, Sarah Buchko, Raven Arly Gonzales, Korey Sutherland, Jenna Van Roekel, Alveena Babul, Ken Tanaka, Kofi Vandyck, Amir Butt, Hisako Okada, Robert Tanzola, Reegan Tod, Aiden Scholey, Wafaa Haider, Ester Cisneros-Aguilera, Alexandre Bergeron, Genevieve Belanger, Darren Mullane, Bevan Hughes, Sakara Hutspardol, Shirley Lim, Jian Mi, Debbie Kalar, Matthew Eang, Erick Lorenzana-Saldivar, Edward P Chen, Akash Gupta, Philip Lau, Pablo Perez D’Empaire, Chantal Armali, Amie Malkin, Connie Colavecchia, Harley Meirovich, Annie Bergeron, Francois Laforge, Kim Paradis, Nathalie Gagne, Marie Soleil Saillant, Marie-Claude Vézina, Olivier Royer, Marie-Ève Charest, Lee-Anne Fochesato, Yuxin Bai, Iqbal Jaffar, Nour Alhomsi, Janine Guevarra, Erin Jamula, Wan Chien (Betty) Hsu, Abbey Drew, Hakan Buyukdere, Drashtee Patel, Elizabeth Watt, Hadia Arabi Katbi, Kim Luciano, Amy Moorehead, Kamola Kasimova, Farzana Tasmin, Cielo Bingley, Victoria Barkley, Tob Reegan, Marianna Qu, Jessica Xiong, Sophie Robichaud, Christy Peterson, Manu Jairath, Mathew Tang, Jennita Aariaratnam, Leron DuMerton, Lucas Drew, Sahrish Masood, Toni Tidy, Elizabeth Krok

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Introduction Reduced thrombin generation is an important component of post cardiopulmonary bypass (CPB) coagulopathy. To replenish coagulation factors and enhance thrombin generation in bleeding surgical patients, frozen plasma (FP) and four-factor p

Externí odkaz: https://doaj.org/article/f4b23ce7268143bca04256dccb1c3cbf

Commentary: Can in vitro valve testing reliably predict clinical outcomes?Central Message

Autor: Hugo M.N. Issa, MD, Fraser Rubens, MD, MSc, FACS, FRCSC

Publikováno v: JTCVS Open, Vol 9, Iss , Pp 57-58 (2022)

Externí odkaz: https://doaj.org/article/347766681ef748d59da7d2b6b7b6a92b

Combining Aortic Size With Arterial Hemodynamics Enhances Assessment of Future Thoracic Aortic Aneurysm Expansion

Autor: Tina Zhu, Owais Mian, Munir Boodhwani, Luc Beauchesne, Carole Dennie, Kwan Chan, George A. Wells, Fraser Rubens, Thais Coutinho

Publikováno v: The Canadian journal of cardiology.

Thoracic aortic aneurysm (TAA) is a deadly disease whose current method for risk stratification (aneurysm size) is imperfect. We sought to evaluate whether combining aortic size with hemodynamic measures that reflect the aorta's function was superior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffe22e96ac49c17e68a15fe4dde720c
https://pubmed.ncbi.nlm.nih.gov/36374804

Diagnosing acute aortic syndrome: a Canadian clinical practice guideline

Autor: Jeffrey Middaugh, Ashish Gupta, Stephen J. Bignucolo, Justin W. Yan, Dominique R. Ansell, Bindu Bittira, Fraser Rubens, Terena-Marie Scott, Prasad Jetty, Rony Atoui, Yvonne Callaway, Alexis Cournoyer, David W. Savage, Krishan Yadav, Niamh Coffey, Sarah McIsaac, Brock Wilson, Eddy Lang, Robert Ohle

Publikováno v: CMAJ

KEY POINTS Acute aortic syndrome (AAS) is a life-threatening emergency, accounting for 1/2000 presentations of acute chest or back pain to the emergency department.[1][1] It is a clinical spectrum of diagnoses including aortic dissection, intramural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a5342a18d98576e4a3479ebd6e5cf4
https://pubmed.ncbi.nlm.nih.gov/32690558

Ischemic and bleeding outcomes after coronary artery bypass grafting among patients initially treated with a P2Y

Autor: Juan J, Russo, Tyler E, James, Marc, Ruel, Jean-Yves, Dupuis, Kuljit, Singh, Daniel, Goubran, Nikita, Malhotra, Fraser, Rubens, Aun-Yeong, Chong, Benjamin, Hibbert, Paul, Boland, Diem Tt, Tran, Jean-Francois, Tanguay, Marie, Lordkipanidzé, Louis, Perrault, George A, Wells, Michael, Bourke, Vincent, Chan, Derek Yf, So

Publikováno v: European heart journal. Acute cardiovascular care. 8(6)

Clinical outcomes in acute coronary syndrome patients treated with P2YWe examined clinical outcomes in acute coronary syndrome patients in relation to the timing of CABG following P2YAmong 508 patients (95 ticagrelor, 413 clopidogrel), the timing of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::994327fa59d0da4f1fc15e99cc100fb3
https://pubmed.ncbi.nlm.nih.gov/29313713