Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Fraser, J. Scott"'
Autor:
Fraser, J. Scott1 scott.fraser@wright.edu
Publikováno v:
Journal of Systemic Therapies. Fall2023, Vol. 42 Issue 3, p43-47. 5p.
Autor:
Charlotte Hind, Melanie Clifford, Charlotte Woolley, Jane Harmer, Leah M. C. McGee, Izaak Tyson-Hirst, Henry J. Tait, Daniel P. Brooke, Stephanie J. Dancer, Iain S. Hunter, Colin J. Suckling, Rebecca Beveridge, John A. Parkinson, J. Mark Sutton, Fraser J. Scott
Publikováno v:
ACS Infectious Diseases. 8:2552-2563
MGB-BP-3 is a potential first-in-class antibiotic, a Strathclyde Minor Groove Binder (S-MGB), that has successfully completed Phase IIa clinical trials for the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd40ee75d50fe78bef77a7f42c5f6f2
https://doi.org/10.1021/acsinfecdis.2c00445
https://doi.org/10.1021/acsinfecdis.2c00445
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 73, Iss 2, Pp 254-259 (2017)
The title nitropyrrole-based compounds, C7H8N2O4, (I) (ethyl 4-nitro-1H-pyrrole-2-carboxylate), its derivative C12H14N2O4, (II) [ethyl 4-nitro-1-(4-pentynyl)-1H-pyrrole-2-carboxylate], C15H26N4O3, (III) {N-[3-(dimethyamino)propyl]-1-isopentyl-4-nitro
Externí odkaz:
https://doaj.org/article/705954ef2b0b464a99d26516515c507e
Autor:
Christian Tentellino, William J. Tipping, Leah M. C. McGee, Laura M. Bain, Corinna Wetherill, Stacey Laing, Izaak Tyson-Hirst, Colin J. Suckling, Rebecca Beveridge, Fraser J. Scott, Karen Faulds, Duncan Graham
Publikováno v:
RSC Chemical Biology. 3:1403-1415
Quantitative drug imaging in live cells is a major challenge in drug discovery and development. Many drug screening techniques are performed in solution, and therefore do not consider the impact of the complex cellular environment in their result. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1a34b9743ec9bc7293589a4af155fa
https://doi.org/10.1039/d2cb00159d
https://doi.org/10.1039/d2cb00159d
Autor:
Fraser, J. Scott
Publikováno v:
Journal of Systemic Therapies. Summer2020, Vol. 39 Issue 2, p65-83. 19p.
Autor:
Fraser, J. Scott1 scott.fraser@wright.edu
Publikováno v:
Journal of Systemic Therapies. Summer2020, Vol. 39 Issue 2, p51-63. 13p.
Autor:
Fraser, J. Scott1 scott.fraser@wright.edu
Publikováno v:
Journal of Systemic Therapies. Summer2020, Vol. 39 Issue 2, p17-22. 6p.
Autor:
Fraser J. Scott, Abedawn I. Khalaf, C. D. Shaw, Jasmine M. Cross, Colin J. Suckling, Kirsten Gillingwater, Craig Irving, Katharine C. Carter, Michael P. Barrett, Federica Giordani, Daniel P. Brooke, Leah M. C. McGee
Publikováno v:
RSC Medicinal Chemistry
This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural product, disgocidine. S-MGBs have been found to be act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf3ca14144cbb02399ebbd23d4e626a
http://europepmc.org/articles/PMC8372214
http://europepmc.org/articles/PMC8372214
Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification
Autor:
Marina C. Perieteanu, Leah M. C. McGee, Craig D. Shaw, Donna S. MacMillan, Abedawn I. Khalaf, Kirsten Gillingwater, Rebecca Beveridge, Katharine C. Carter, Colin J. Suckling, Fraser J. Scott
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11912
The neglected tropical disease leishmaniasis, caused by Leishmania spp., is becoming more problematic due to the emergence of drug-resistant strains. Therefore, new drugs to treat leishmaniasis, with novel mechanisms of action, are urgently required.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23ea601476867fa05b6fef3c2e74b60
https://pubmed.ncbi.nlm.nih.gov/36233213
https://pubmed.ncbi.nlm.nih.gov/36233213