Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Fraser, Hof"'
Autor:
Amelia Richter, Darcy Sutherland, Hossein Ebrahimikondori, Alana Babcock, Nathan Louie, Chenkai Li, Lauren Coombe, Diana Lin, René L. Warren, Anat Yanai, Monica Kotkoff, Caren C. Helbing, Fraser Hof, Linda M. N. Hoang, Inanc Birol
Publikováno v:
Antibiotics, Vol 11, Iss 12, p 1710 (2022)
Antimicrobial peptides (AMPs) are a diverse class of short, often cationic biological molecules that present promising opportunities in the development of new therapeutics to combat antimicrobial resistance. Newly developed in silico methods offer th
Externí odkaz:
https://doaj.org/article/aa2df13f90d04d4bb4d069a5df8c6fb1
Autor:
Allison Selinger, Fraser Hof
Molecular differentiation by supramolecular sensors is typically achieved through sensor arrays, relying on the pattern recognition responses of large panels of isolated sensing elements. Here we report a new one-pot systems chemistry approach to dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dbfcd6ffe0beda71e48613e9cea183e
https://doi.org/10.26434/chemrxiv-2023-2wr6j
https://doi.org/10.26434/chemrxiv-2023-2wr6j
Autor:
Chakravarthi Simhadri, Michael C. Gignac, Cameron J. Anderson, Natalia Milosevich, Aman Dheri, Nishant Prashar, Robert T. Flemmer, Amarjot Dev, Trevor G. Henderson, Sarah F. Douglas, Jeremy E. Wulff, Fraser Hof
Publikováno v:
ACS Omega, Vol 1, Iss 4, Pp 541-551 (2016)
Externí odkaz:
https://doaj.org/article/8d4a07e97fb14d7692b36deb20a05050
Autor:
David King, Chelsea R. Wilson, Lukas Herron, Chun-Lin Deng, Shams Mehdi, Pratyush Tiwary, Fraser Hof, Lyle Isaacs
Publikováno v:
Organic & Biomolecular Chemistry. 20:7429-7438
The molecular recognition properties of Pillar[6]MaxQ toward methylated amino acids, amino acid amides, and peptides is investigated by a combination of 1H NMR, ITC, indicator displacements assays, and molecular dynamics simulations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cf7ebfee14dac0ffdb3e4d3fbf1d7c
https://doi.org/10.1039/d2ob01487d
https://doi.org/10.1039/d2ob01487d
Publikováno v:
The Journal of Organic Chemistry. 86:10782-10787
We carried out steady-state and stopped-flow photophysical measurements to determine the kinetics of a discrete disassembly driven turn-on fluorescent system. On and off rates for both DimerDye1 assembly and nicotine binding were determined. Relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5723aa6164b93947e4e0f654a10a323
https://doi.org/10.1021/acs.joc.1c00959
https://doi.org/10.1021/acs.joc.1c00959
Autor:
Graham A. E. Garnett, Mark C. Grasdal, Melissa J. Starke, Fraser Hof, Anton Y. Kliuchynskyi, Alok Shaurya, Charlotte C. Dewar
Publikováno v:
Organic & Biomolecular Chemistry. 19:4691-4696
Post-translational modifications (PTMs) are critical controllers of protein functions. One set of important PTMs are N-methylated side chains of lysine and arginine, which exist in several functionally distinct forms. Multiple groups have demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0ddcf86c730affa80180561e7044517
https://doi.org/10.1039/d1ob00524c
https://doi.org/10.1039/d1ob00524c
Autor:
Natalia Milosevich, Katrina H. Vizely, Roko P.A. Nikolic, Jacob F. McCallum, Lee M. Treanor, Sarah S. Khan, Ratmir Derda, Fraser Hof
We report a synthetic methodology for the installation of methyllysine mimics on cysteine-containing peptides and bacteriophage peptide libraries. Strategies that allow for diversity and high throughput screening of PTM-containing peptides are critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed988616b1c2fd75c89647f7ea410e6
https://doi.org/10.26434/chemrxiv-2022-1lkkx
https://doi.org/10.26434/chemrxiv-2022-1lkkx
Autor:
Xing Wang, Fraser Hof
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1-10 (2012)
1,3,5-triethylbenzenes have been widely used as supramolecular templates to organize molecular-recognition elements. It is believed that the steric-gearing effect of the 1,3,5-triethylbenzene template directs the binding elements toward the same face
Externí odkaz:
https://doaj.org/article/f9908bbb257e4850830b1843d38451d2
Publikováno v:
Angewandte Chemie International Edition. 61
We report on the synthesis of bivalent water-soluble calix[4]arene and calix[5]arene hosts, Super-sCx4 and Super-sCx5 as new broad-spectrum supramolecular binders of neuromuscular blocking agents (NMBAs). Synthesis was achieved using the target bisqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122bd4d83612c658a7357a67a3b3953a
https://doi.org/10.1002/anie.202113235
https://doi.org/10.1002/anie.202113235
We report on the synthesis of bivalent water soluble calix[4]arene and calix[5]arene hosts, Super-sCx4 and Super-sCx5 as new broad-spectrum supramolecular binders of neuromuscular blocking agents (NMBAs). Synthesis was achieved using the target bisqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb6787b9c44a030dbf6ada6ab35815f
https://doi.org/10.33774/chemrxiv-2021-zq9z2
https://doi.org/10.33774/chemrxiv-2021-zq9z2