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Akademický článek

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects

Autor: Amelia Richter, Darcy Sutherland, Hossein Ebrahimikondori, Alana Babcock, Nathan Louie, Chenkai Li, Lauren Coombe, Diana Lin, René L. Warren, Anat Yanai, Monica Kotkoff, Caren C. Helbing, Fraser Hof, Linda M. N. Hoang, Inanc Birol

Publikováno v: Antibiotics, Vol 11, Iss 12, p 1710 (2022)

Antimicrobial peptides (AMPs) are a diverse class of short, often cationic biological molecules that present promising opportunities in the development of new therapeutics to combat antimicrobial resistance. Newly developed in silico methods offer th

Externí odkaz: https://doaj.org/article/aa2df13f90d04d4bb4d069a5df8c6fb1

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Adaptive Supramolecular Networks: Emergent Sensing from Complex Systems

Autor: Allison Selinger, Fraser Hof

Molecular differentiation by supramolecular sensors is typically achieved through sensor arrays, relying on the pattern recognition responses of large panels of isolated sensing elements. Here we report a new one-pot systems chemistry approach to dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dbfcd6ffe0beda71e48613e9cea183e
https://doi.org/10.26434/chemrxiv-2023-2wr6j

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Periodical

Chiral Guests and Their Ghosts in Reversibly Assembled Hosts This work was supported by the Skaggs Research Foundation and the National Institutes of Health. The Administracíon de Fomento Económico of Puerto Rico provided fellowship support to J.M.R. The Ministerio de Educación y Cultura of Spain provided fellowship support to T.M. We thank Fraser Hof for assistance with molecular graphics design.

Autor: Rivera, José M., Craig, Stephen L., Martín, Tomás, Rebek, Julius, Jr.

Publikováno v: Angewandte Chemie. International Edition; June 16, 2000, Vol. 39 Issue: 12 p2130-2132, 3p

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Akademický článek

Structure–Activity Relationships of Cbx7 Inhibitors, Including Selectivity Studies against Other Cbx Proteins

Autor: Chakravarthi Simhadri, Michael C. Gignac, Cameron J. Anderson, Natalia Milosevich, Aman Dheri, Nishant Prashar, Robert T. Flemmer, Amarjot Dev, Trevor G. Henderson, Sarah F. Douglas, Jeremy E. Wulff, Fraser Hof

Publikováno v: ACS Omega, Vol 1, Iss 4, Pp 541-551 (2016)

Externí odkaz: https://doaj.org/article/8d4a07e97fb14d7692b36deb20a05050

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Molecular recognition of methylated amino acids and peptides by Pillar[6]MaxQ

Autor: David King, Chelsea R. Wilson, Lukas Herron, Chun-Lin Deng, Shams Mehdi, Pratyush Tiwary, Fraser Hof, Lyle Isaacs

Publikováno v: Organic & Biomolecular Chemistry. 20:7429-7438

The molecular recognition properties of Pillar[6]MaxQ toward methylated amino acids, amino acid amides, and peptides is investigated by a combination of 1H NMR, ITC, indicator displacements assays, and molecular dynamics simulations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cf7ebfee14dac0ffdb3e4d3fbf1d7c
https://doi.org/10.1039/d2ob01487d

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Mechanism of a Disassembly-Driven Sensing System Studied by Stopped-Flow Kinetics

Autor: Cara Gallo, Suma S. Thomas, Fraser Hof, Allison J Selinger, Cornelia Bohne

Publikováno v: The Journal of Organic Chemistry. 86:10782-10787

We carried out steady-state and stopped-flow photophysical measurements to determine the kinetics of a discrete disassembly driven turn-on fluorescent system. On and off rates for both DimerDye1 assembly and nicotine binding were determined. Relative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5723aa6164b93947e4e0f654a10a323
https://doi.org/10.1021/acs.joc.1c00959

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An easily accessible, lower rim substituted calix[4]arene selectively binds N,N-dimethyllysine

Autor: Graham A. E. Garnett, Mark C. Grasdal, Melissa J. Starke, Fraser Hof, Anton Y. Kliuchynskyi, Alok Shaurya, Charlotte C. Dewar

Publikováno v: Organic & Biomolecular Chemistry. 19:4691-4696

Post-translational modifications (PTMs) are critical controllers of protein functions. One set of important PTMs are N-methylated side chains of lysine and arginine, which exist in several functionally distinct forms. Multiple groups have demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0ddcf86c730affa80180561e7044517
https://doi.org/10.1039/d1ob00524c

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