Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury.

Autor: Genovese, Tiziana¹ tgenovese@unime.it, Cuzzocrea, Salvatore¹ salvator@unime.it, Di Paola, Rosanna¹ dipaolar@unime.it, Failla, Marco² marcofailla@yahoo.it, Mazzon, Emanuela¹ ehazzon@unime.it, Sortino, Maria Angela³ ccrisafulli@unime.it, Frasca, Giuseppina³ rosanna103@interfree.it, Gili, Elisa² elisa@libero.it, Crimi, Nunzio² salvaor@imeuniv.unime.it, Caputi, Achille P.¹ apcaputi@unime.it, Vancheri, Carlo² vancheri@unict.it

Publikováno v: Respiratory Research. 2005, Vol. 6, p58-17. 17p.

Design of Benzene-1,2-diamines as selective inducible nitric oxide synthase inhibitors: a combined de novo design and docking analysis.

Autor: Sandrea Francis, Amit Mittal, Manishika Sharma, Prasad Bharatam

Publikováno v: Journal of Molecular Modeling; Mar2008, Vol. 14 Issue 3, p215-224, 10p

GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain.

Autor: De Alba J; Department of Respiratory Pharmacology, RI CEDD GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK Department of Pain, Neurology+GI CEDD, GlaxoSmithKline Research and Development, New Frontiers Science Park, Third Avenue. Harlow, Essex CM19 5AW, UK Department of Drug Metabolism and Pharmacokinetics, DMPK, GlaxoSmithKline Research and Development Park Road, Ware, Hertfordshire SG12 ODP, UK., Clayton NM, Collins SD, Colthup P, Chessell I, Knowles RG

Publikováno v: Pain [Pain] 2006 Jan; Vol. 120 (1-2), pp. 170-181. Date of Electronic Publication: 2005 Dec 19.