Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Franziska U. Wöhrle"'
Autor:
Martin Werner, Franziska U. Wöhrle, Sebastian Halbach, Sandra Braun, Konrad Aumann, Robert Zeiser, Daniel Schramek, Roger J. Daly, Silke Laßmann, Cornelius F. Waller, S Schwemmers, Josef M. Penninger, Patrick Auberger, Heike L. Pahl, Tilman Brummer
Publikováno v:
Leukemia
Grb2-associated binder 2 (Gab2) serves as a critical amplifier in the signaling network of Bcr-Abl, the driver of chronic myeloid leukemia (CML). Despite the success of tyrosine kinase inhibitors (TKIs) in CML treatment, TKI resistance, caused by mut
Autor:
Sebastian, Halbach, Zehan, Hu, Christine, Gretzmeier, Julia, Ellermann, Franziska U, Wöhrle, Jörn, Dengjel, Tilman, Brummer
Publikováno v:
Cell Communication and Signaling : CCS
Background Chronic myeloid leukemia (CML) is driven by the fusion kinase Bcr-Abl. Bcr-Abl tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM), revolutionized CML therapy. Nevertheless, about 20 % of CMLs display primary or acquired TKI
Publikováno v:
Structure. 17:779-781
In this issue of Structure , Harkiolaki et al. use crystallography, peptide arrays and isothermal calorimetry to provide a detailed insight into the interaction between the C-terminal SH3 domain of adaptor protein Grb2 bound to the docking protein Ga
Publikováno v:
Cell Communication and Signaling, Vol 9, Iss 1, p 17 (2011)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Introduction Non-transformed mammary epithelial cell lines such as MCF-10A recapitulate epithelial morphogenesis in three-dimensional (3D) tissue culture by forming acinar structures. They represent an important tool to characterize the biological pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cd54aa26f0a160a3baac1919dd6288c6
https://opus4.kobv.de/opus4-fau/files/2473/herr_novel_3649.pdf
https://opus4.kobv.de/opus4-fau/files/2473/herr_novel_3649.pdf
Publikováno v:
Circulation journal : official journal of the Japanese Circulation Society. 76(8)
Autor:
Robert Zeiser, Cornelius F. Waller, Tilman Brummer, Annette M. May, Konrad Aumann, Franziska U. Wöhrle, Martin Werner, Silke Lassmann, Dieter Hauschke, Anja Schöpflin
Publikováno v:
Human pathology. 42(5)
Grb2-associated binder 2 protein (Gab2) is a member of scaffold proteins, playing crucial roles in (receptor-) tyrosine kinase and cytokine signaling. Chronic myeloid leukemia cells with t(9;22)(q34;q11) express the Bcr/Abl fusion protein, which inte
Publikováno v:
Cell Communication and Signaling, Vol 7, Iss 1, p 22 (2009)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Since their discovery a little more than a decade ago, the docking proteins of the Gab/DOS family have emerged as important signalling elements in metazoans. Gab/DOS proteins integrate and amplify signals from a wide variety of sources including grow
Publikováno v:
Cancer Research. 75:2708-2708
Chronic myeloid leukemia (CML) is driven by the hyperactive fusion kinase Bcr-Abl, generated by a chromosomal translocation between chromosome 9 and 22. This oncogenic tyrosine kinase builds up its own signaling network with various proteins such as