Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Franziska U. Huschmann"'
Autor:
Franziska U. Huschmann, Janis Mueller, Alexander Metz, Moritz Ruf, Johanna Senst, Serghei Glinca, Johannes Schiebel, Andreas Heine, Gerhard Klebe
Publikováno v:
Crystals, Vol 14, Iss 9, p 755 (2024)
Fragment screening directly on protein crystals has been applied using AnalytiCon’s collection of intermediates that have been utilized to generate libraries of larger synthetic natural product-like molecules. The fragments with well-balanced physi
Externí odkaz:
https://doaj.org/article/4e95b53a82e24820bf05c4f364b32dbd
Autor:
Gerhard Klebe, Dirk Wallacher, Franziska U. Huschmann, T. Barthel, Manfred S. Weiss, J. Wollenhaupt, Christian G. Feiler
Publikováno v:
Journal of Applied Crystallography
In the past two decades, most of the steps in a macromolecular crystallography experiment have undergone tremendous development with respect to speed, feasibility and increase of throughput. The part of the experimental workflow that is still a bottl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3859b56aad381781a24e3a7ab1ed045
Autor:
Alexander Metz, Uwe Mueller, Michael Steffien, Ronald Förster, Dirk Wallacher, T. Barthel, Andreas Heine, E. Jagudin, J. Wollenhaupt, Martin Gerlach, Gerhard Klebe, Franziska U. Huschmann, Christian G. Feiler, Manfred S. Weiss, Michael Hellmig, G.M.A. Lima, Thomas Hauß
Publikováno v:
Journal of Visualized Experiments
Fragment screening is a technique that helps to identify promising starting points for ligand design. Given that crystals of the target protein are available and display reproducibly high resolution X ray diffraction properties, crystallography is am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8925c0d7c4b19dd36fa9de5845e542
http://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=103889
http://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=103889
Publikováno v:
Purinergic Signalling
Human ecto-5-nucleotidase (CD73) is involved in purinergic signalling, which influences a diverse range of biological processes. CD73 hydrolyses AMP and is the major control point for the levels of extracellular adenosine. Inhibitors of CD73 thus blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a813e8e77b98a9b76464fad53511fc
http://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=103992
http://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=103992
Autor:
J. Schiebel, Johan Winquist, Ah Young Park, Franziska U. Huschmann, Xiaojie Wang, Andreas Heine, F.R. Ehrmann, Michael Betz, Gerhard Klebe, Manfred S. Weiss, Martin Stieler, Uwe Mueller, S.G. Krimmer, Nedyalka Radeva, Thomas Rickmeyer, Alexander Metz, Kan Fu
Publikováno v:
Journal of Medicinal Chemistry. 59:9743-9759
Crystallography is frequently used as follow-up method to validate hits identified by biophysical screening cascades. The capacity of crystallography to directly screen fragment libraries is often underestimated, due to its supposed low-throughput an
Autor:
Anna Knörlein, Michael Krug, Andreas Heine, Ah Young Park, Karine Röwer, Uwe Mueller, Franziska U. Huschmann, S.G. Krimmer, J. Schiebel, Manfred S. Weiss, F.R. Ehrmann, Kan Fu, Xiaojie Wang, Steffen Glöckner, Gerhard Klebe, Martin Stieler, Nedyalka Radeva
Publikováno v:
Structure. 24:1398-1409
Today the identification of lead structures for drug development often starts from small fragment-like molecules raising the chances to find compounds that successfully pass clinical trials. At the heart of the screening for fragments binding to a sp
Autor:
Andreas Heine, Nedyalka Radeva, Martin Stieler, Franziska U. Huschmann, Uwe Mueller, Alexander Metz, Xiaojie Wang, S.G. Krimmer, Manfred S. Weiss, F.R. Ehrmann, Kan Fu, J. Schiebel, Gerhard Klebe
Publikováno v:
ACS Chemical Biology. 11:1693-1701
Fragment-based lead discovery (FBLD) has become a pillar in drug development. Typical applications of this method comprise at least two biophysical screens as prefilter and a follow-up crystallographic experiment on a subset of fragments. Clearly, st
Autor:
J. Schiebel, F.R. Ehrmann, Kan Fu, Gerhard Klebe, Andreas Heine, Manfred S. Weiss, Uwe Mueller, S.G. Krimmer, Alexander Metz, Martin Stieler, Nedyalka Radeva, Franziska U. Huschmann, Xiaojie Wang
Publikováno v:
Journal of medicinal chemistry. 59(16)
Successful optimization of a given lead scaffold requires thorough binding-site mapping of the target protein particular in regions remote from the catalytic center where high conservation across protein families is given. We screened a 361-entry fra
Autor:
Manfred S. Weiss, Xiaojie Wang, Uwe Mueller, J. Schiebel, Alexander Metz, Monika Ühlein, Gerhard Klebe, Karine Sparta, J. Linnik, Franziska U. Huschmann, Andreas Heine
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 72(Pt 5)
Crystallographic screening of the binding of small organic compounds (termed fragments) to proteins is increasingly important for medicinal chemistry-oriented drug discovery. To enable such experiments in a widespread manner, an affordable 96-compoun
Autor:
Manfred S. Weiss, J. Schiebel, Alexander Metz, Uwe Müller, Andreas Heine, Franziska U. Huschmann, Gerhard Klebe
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 74:e24-e24