Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Franziska Theilig"'
Autor:
Madlen Kunke, Hannah Knöfler, Eileen Dahlke, Luis Zanon Rodriguez, Martina Böttner, Alexey Larionov, Makhabbat Saudenova, Gerrit M. Ohrenschall, Magdalena Westermann, Stefan Porubsky, Joana P. Bernardes, Robert Häsler, Jean-Luc Magnin, Hermann Koepsell, François Jouret, Franziska Theilig
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-15 (2023)
Abstract Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Glomerular hyperfiltration and albuminuria subject the proximal tubule (PT) to a subsequent elevation of workload, growth, and hypoxia. Hypoxia plays an ambiguous
Externí odkaz:
https://doaj.org/article/1d09297137c0436ba5385716be600ed8
Autor:
Gerrit Hugendieck, Marcus Lettau, Svenja Andreas, Sabrina Neumann, Natalie Reinhardt, Philipp Arnold, Franziska Theilig, Lorenz Bastian, Christoph Rogmans, Jörg P. Weimer, Inken Flörkemeier, Daniela Wesch, Norbert Arnold, Nicolai Maass, Ottmar Janssen, Dirk Bauerschlag, Nina Hedemann
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 7, Pp n/a-n/a (2023)
Abstract Ovarian cancer (OvCa) is the gynaecological disorder with the poorest prognosis due to the fast development of chemoresistance. We sought to connect chemoresistance and cancer cell‐derived extracellular vesicles (EV). The mechanisms of how
Externí odkaz:
https://doaj.org/article/b608a4f57c4247b186f7a69bb4075f92
Autor:
Arianna Mazzoli, Claudia Sardi, Ludovic Breasson, Franziska Theilig, Barbara Becattini, Giovanni Solinas
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 2, Pp 94-107 (2021)
Abstract The cJun N‐terminal Kinases (JNK) emerged as a major link between obesity and insulin resistance, but their role in the loss of pancreatic β‐cell mass and function driving the progression from insulin resistance to type‐2 diabetes and
Externí odkaz:
https://doaj.org/article/c496186e3bfe449e91a07039b69b1407
Autor:
Eileen Dahlke, Yaman Anan, Lea Maximiliane Klie, Ariane Elisabeth Hartkopf, Franziska Theilig
Publikováno v:
Cells, Vol 12, Iss 1, p 53 (2022)
The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine. The initial event of this transcellular transport mechanism is
Externí odkaz:
https://doaj.org/article/7ec9b1a82e75477d96d850fffb5ab0e2
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10199 (2022)
Acute kidney injury (AKI) is a common renal injury leading to relevant morbidity and mortality worldwide. Most of the clinical cases of AKI are caused by ischemia reperfusion (I/R) injury with renal ischemia injury followed by reperfusion injury and
Externí odkaz:
https://doaj.org/article/129f50c7ba054a32891d75ee7719519a
Autor:
Brandi M. Wynne, Abinash C. Mistry, Otor Al-Khalili, Rickta Mallick, Franziska Theilig, Douglas C. Eaton, Robert S. Hoover
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Distal sodium transport is a final step in the regulation of blood pressure. As such, understanding how the two main sodium transport proteins, the thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENa
Externí odkaz:
https://doaj.org/article/5a57c393beb9449b97dd8ad6093995d4
Autor:
Nicole Eisele, Rahel Klossner, Geneviève Escher, Stefan Rudloff, Alexey Larionov, Franziska Theilig, Markus G. Mohaupt, Hiten D. Mistry, Carine Gennari‐Moser
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 15 (2018)
Background In pregnancy, a high plasma volume maintains uteroplacental perfusion and prevents placental ischemia, a condition linked to elevated maternal blood pressure (BP). Reducing BP by increasing Na+ intake via plasma volume expansion appears co
Externí odkaz:
https://doaj.org/article/0a1a22135d7d4371a3d742c988f83422
Autor:
Cynthia Bülck, Elisabeth E. L. Nyström, Tomas Koudelka, Michael Mannbar-Frahm, Gerrit Andresen, Mariem Radhouani, Florian Tran, Franka Scharfenberg, Friederike Schrell, Fred Armbrust, Eileen Dahlke, Bei Zhao, Alex Vervaeke, Franziska Theilig, Philip Rosenstiel, Philipp Starkl, Stephan P. Rosshart, Helmut Fickenscher, Andreas Tholey, Gunnar C. Hansson, Christoph Becker-Pauly
Publikováno v:
Science Advances. 9
The metalloproteases meprin α and meprin β are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease, implicating a protective role in mucosal homeostasis. In the colon, meprin α and meprin β form covalentl
Autor:
Markus M. Rinschen, Jennifer L. Harder, Madalina E. Carter-Timofte, Luis Zanon Rodriguez, Carmen Mirabelli, Fatih Demir, Naziia Kurmasheva, Suresh K. Ramakrishnan, Madlen Kunke, Yifan Tan, Anja Billing, Eileen Dahlke, Alexey A. Larionov, Wibke Bechtel-Walz, Ute Aukschun, Marlen Grabbe, Rikke Nielsen, Erik I. Christensen, Matthias Kretzler, Tobias B. Huber, Christiane E. Wobus, David Olagnier, Gary Siuzdak, Florian Grahammer, Franziska Theilig
Publikováno v:
Rinschen, M M, Harder, J L, Carter-Timofte, M E, Zanon Rodriguez, L, Mirabelli, C, Demir, F, Kurmasheva, N, Ramakrishnan, S K, Kunke, M, Tan, Y, Billing, A, Dahlke, E, Larionov, A A, Bechtel-Walz, W, Aukschun, U, Grabbe, M, Nielsen, R, Christensen, E I, Kretzler, M, Huber, T B, Wobus, C E, Olagnier, D, Siuzdak, G, Grahammer, F & Theilig, F 2022, ' VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney ', Science Signaling, vol. 15, no. 762, pp. eabo7940 . https://doi.org/10.1126/scisignal.abo7940
The lipid kinase VPS34 orchestrates autophagy, endocytosis, and metabolism and is implicated in cancer and metabolic disease. The proximal tubule in the kidney is a key metabolic organ that controls reabsorption of nutrients such as fatty acids, amin
Autor:
Eileen, Dahlke, Toni, Engmann, Yaman, Anan, Robert, Häsler, Giovanni, Solinas, Franziska, Theilig
Publikováno v:
International journal of molecular sciences. 23(17)
Acute kidney injury (AKI) is a common renal injury leading to relevant morbidity and mortality worldwide. Most of the clinical cases of AKI are caused by ischemia reperfusion (I/R) injury with renal ischemia injury followed by reperfusion injury and