Expression of a large coding sequence: Gene therapy vectors for Ataxia Telangiectasia

Autor: Tanja Hirch, Nadine Brander, Franziska Schenk, Simon J. Pöllmann, Janine Reichenbach, Ralf Schubert, Ute Modlich

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract Ataxia telangiectasia is a monogenetic disorder caused by mutations in the ATM gene. Its encoded protein kinase ATM plays a fundamental role in DNA repair of double strand breaks (DSBs). Impaired function of this kinase leads to a multisyste

Externí odkaz: https://doaj.org/article/0fa81c50e414411d8c70f75fba245208

Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output

Autor: Marcel G.E. Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Csaba Miskey, Lacramioara Botezatu, Yvonne Krebs, Iris M. Voelker, Kevin Wittwer, Tim Holland-Letz, Zoltán Ivics, Veronika von Messling, Marieke A.G. Essers, Michael D. Milsom, Christian K. Pfaller, Ute Modlich

Publikováno v: Cell Reports, Vol 41, Iss 1, Pp 111447- (2022)

Summary: Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem and pr

Externí odkaz: https://doaj.org/article/4f2b90b0b8ec49f9816a17097e7b27e9

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy

Autor: Sara El Ashkar, Dominique Van Looveren, Franziska Schenk, Lenard S. Vranckx, Jonas Demeulemeester, Jan De Rijck, Zeger Debyser, Ute Modlich, Rik Gijsbers

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 231-245 (2017)

Retroviral vectors have shown their curative potential in clinical trials correcting monogenetic disorders. However, therapeutic benefits were compromised due to vector-induced dysregulation of cellular genes and leukemia development in a subset of p

Externí odkaz: https://doaj.org/article/efc62190fa804a3383b84d8e992681cc

Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice

Autor: Ute Modlich, Saskia Kohlscheen, Franziska Schenk, Marcel G. E. Rommel, Katharina Cullmann

Publikováno v: Blood. 133:1465-1478

Thrombopoietin (Thpo)/myeloproliferative leukemia virus oncogene (Mpl) signaling controls hematopoietic stem cell (HSC) self-renewal and quiescence; however, how these 2 seemingly opposing functions are controlled is not well understood. By transplan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66006e67e0c18f457260f7bca94d7a3c
https://doi.org/10.1182/blood-2018-03-837344

Forming megakaryocytes from murine-induced pluripotent stem cells by the inducible overexpression of supporting factors

Autor: Adele Mucci, Markus Bender, Ute Modlich, Magdalena Jahn, Harald Schulze, Thomas Moritz, Georgi Manukjan, Franziska Schenk, Doris Steinemann, Markus Spindler, Klaus Boller, Katharina Cullmann

Publikováno v: Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 1, Pp 111-124 (2021)
Research and practice in thrombosis and haemostasis, 5(1):111-124

Background Platelets are small anucleate cells that circulate in the blood in a resting state but can be activated by external cues. In case of need, platelets from blood donors can be transfused. As an alternative source, platelets can be produced f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77edcb8111b17f34252611c22b129d76
https://pubmed.ncbi.nlm.nih.gov/33537535