Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Franziska Schaedeli"'
Autor:
Zrinka Duvnjak, Franziska Schaedeli Stark, Valérie Cosson, Sylvie Retout, Emilie Schindler, João A. Abrantes
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1707-1721 (2024)
Abstract The Pharmpy Automatic Model Development (AMD) tool automates the building of population pharmacokinetic (popPK) models by utilizing a systematic stepwise process. In this study, the performance of the AMD tool was assessed using simulated da
Externí odkaz:
https://doaj.org/article/515b6d8b3f2a493e847418ac626a9951
Akademický článek
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Autor:
Clarisse Chavanne, Navita L. Mallalieu, Valerie Cosson, Elena Guerini, Mona Arab‐Alameddine, Michael Derks, Franziska Schaedeli-Stark
Publikováno v:
Clinical and Translational Science. 11:523-531
Dizziness, the most frequently observed adverse event in patients with major depressive disorder, was observed with basimglurant, a selective, orally active metabotropic glutamate receptor subtype 5 negative allosteric modulator. The potential relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec87d16325e1a56fa723676ecd5253ef
https://doi.org/10.1111/cts.12566
https://doi.org/10.1111/cts.12566
Autor:
Jianguo Zhi, Franziska Schaedeli Stark, Kai Habben, Angelika Lahr, Jean Tessier, Roland F Staack, Eginhard Schick, Ka Wang, Tilman Schlothauer, Oliver Krieter, Valerie Cosson
Publikováno v:
Cancer Chemotherapy and Pharmacology. 79:661-671
RO5323441 is a humanized anti-placental growth factor (PlGF) monoclonal antibody that has shown preclinical activity in several cancer models. The objective of this analysis is to examine the pharmacokinetic (PK) results from four Phase I studies tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9fd7b90e0e4fecc70b0ef6c1aa0696
https://doi.org/10.1007/s00280-017-3242-8
https://doi.org/10.1007/s00280-017-3242-8
Autor:
Franziska Schaedeli Stark, Ekaterina Gibiansky, Leonid Gibiansky, Nicolas Frey, Valerie Cosson
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 41:279-289
This work proposes and evaluates two methods (CM1 and CM2) for detecting non-compliance using concentration-time data and for obtaining estimates of population pharmacokinetic model parameters in a population with prevalent non-compliance. CM1 estima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019086aa28c764ea4449c6bfc1be4d43
https://doi.org/10.1007/s10928-014-9364-2
https://doi.org/10.1007/s10928-014-9364-2
Autor:
Amita Joshi, Ian E. Krop, Franziska Schaedeli-Stark, Manish Gupta, Lena E. Friberg, Reinhold Koch, Sandhya Girish, Yu-Waye Chu, Brendan Bender, Hope S. Rugo
Publikováno v:
Cancer Chemotherapy and Pharmacology. 70:591-601
Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate in the development for the treatment of human epidermal growth factor receptor 2-positive cancers. Thrombocytopenia (TCP) is the dose-limiting toxicity of T-DM1. A semimechanistic population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b78b2e177f0a2b7bb034c64afcf02e
https://doi.org/10.1007/s00280-012-1934-7
https://doi.org/10.1007/s00280-012-1934-7
Autor:
Stephane Nave, Annette Koerner, Erica Winter, Ricardo Hermosilla, Maria Domenica Cappellini, Vip Viprakasit, Ali T. Taher, Franziska Schaedeli Stark, Volz Dietmar, Norman A. Mazer, Patrick Cech, Omar Khwaja, Dominik Kraus, Juergen Dukart
Publikováno v:
Blood. 132:3635-3635
Beta-thalassemia is a hereditary blood disorder characterized by reduced or absent synthesis of the beta-globin chain, one of the major components of adult hemoglobin (Hb). The unbalanced synthesis of globin chains leads to a relative excess of alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::394a9259d2043c5b3b23344eef83eea2
https://doi.org/10.1182/blood-2018-99-114776
https://doi.org/10.1182/blood-2018-99-114776
Akademický článek
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Publikováno v:
Kidney International. 66(1):375-382
The willingness of patients to accept an additional mortality risk in order to improve renal graft survival.BackgroundThis study was performed to assess renal transplant patient preferences with respect to the acceptance of an additional mortality ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facae69705f2c9cda3461e11270566c1
Autor:
Davide Verotta, Franziska Schaedeli
Publikováno v:
Mathematical Biosciences. 176:163-183
Human immunodeficiency virus (HIV) dynamics represent a complicated variant of the text-book case of non-linear dynamics: predator-prey interaction. The interaction can be described as naturally reproducing T-cells (prey) hunted and killed by virus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2c3293d0aaa7cfc67127e4069a18f5
https://doi.org/10.1016/s0025-5564(02)00090-1
https://doi.org/10.1016/s0025-5564(02)00090-1