Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Franziska Preuss"'
Autor:
Martin P. Schwalm, Lena M. Berger, Maximilian N. Meuter, James D. Vasta, Cesear R. Corona, Sandra Röhm, Benedict-Tilman Berger, Frederic Farges, Sebastian M. Beinert, Franziska Preuss, Viktoria Morasch, Vladimir V. Rogov, Sebastian Mathea, Krishna Saxena, Matthew B. Robers, Susanne Müller, Stefan Knapp
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
E3 ligases constitute a large and diverse family of proteins that play a central role in regulating protein homeostasis by recruiting substrate proteins via recruitment domains to the proteasomal degradation machinery. Small molecules can either inhi
Externí odkaz:
https://doaj.org/article/bc038599fbfd4e358a76cbc206775e95
Publikováno v:
Cells, Vol 11, Iss 1, p 142 (2022)
Malfunction of the actin cytoskeleton is linked to numerous human diseases including neurological disorders and cancer. LIMK1 (LIM domain kinase 1) and its paralogue LIMK2 are two closely related kinases that control actin cytoskeleton dynamics. Cons
Externí odkaz:
https://doaj.org/article/2b5b87af83b64bf0b45d353c57b85204
Autor:
Alison D. Axtman, David H. Drewry, Julie E. Pickett, Sebastian Mathea, Franziska Preuss, Carrow I. Wells, Joel K. Annor-Gyamfi, Verena Dederer
Publikováno v:
Journal of Medicinal Chemistry
The pyrimidine core has been utilized extensively to construct kinase inhibitors, including eight FDA-approved drugs. Because the pyrimidine hinge-binding motif is accommodated by many human kinases, kinome-wide selectivity of resultant molecules can
Autor:
Christian G. Kurz, Franziska Preuss, Amelie Tjaden, Martin Cusack, Jennifer Alisa Amrhein, Deep Chatterjee, Sebastian Mathea, Lena Marie Berger, Benedict-Tilman Berger, Andreas Krämer, Michael Weller, Tobias Weiss, Susanne Müller, Stefan Knapp, Thomas Hanke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40655f1daf530ca9d94a99aa49b614e5
https://doi.org/10.5167/uzh-230025
https://doi.org/10.5167/uzh-230025
Autor:
Christian G, Kurz, Franziska, Preuss, Amelie, Tjaden, Martin, Cusack, Jennifer Alisa, Amrhein, Deep, Chatterjee, Sebastian, Mathea, Lena Marie, Berger, Benedict-Tilman, Berger, Andreas, Krämer, Michael, Weller, Tobias, Weiss, Susanne, Müller, Stefan, Knapp, Thomas, Hanke
Publikováno v:
Journal of medicinal chemistry. 65(11)
Serine/threonine kinase 17A (death-associated protein kinase-related apoptosis-inducing protein kinase 1─DRAK1) is a part of the death-associated protein kinase (DAPK) family and belongs to the so-called dark kinome. Thus, the current state of know
Publikováno v:
Methods in enzymology. 667
Pseudokinases play significant roles in disease development. Similar to active kinases, their cellular functions can be targeted pharmacologically. But notably, instead of inhibiting an enzymatic activity, drug-like molecules act by stabilizing disti
Autor:
Andreas C. Joerger, Xiaomin Ni, Sebastian Mathea, Andreas Krämer, Stefan Knapp, Marek Wanior, David Heidenreich, Tamara Göbel, Svenja Simonyi, Franziska Preuss, Astrid S. Kahnt
Publikováno v:
Journal of Medicinal Chemistry. 63:14680-14699
Accessibility of the human genome is modulated by the ATP-driven SWI/SNF chromatin remodeling multiprotein complexes BAF (BRG1/BRM-associated factor) and PBAF (polybromo-associated BAF factor), which involves reading of acetylated histone tails by th
Publikováno v:
Methods in Enzymology ISBN: 9780323915410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3232d53ab05d0e213d8fae6e577b2a0
https://doi.org/10.1016/bs.mie.2022.03.050
https://doi.org/10.1016/bs.mie.2022.03.050
Autor:
Stefan Knapp, Deep Chatterjee, Daniela Ungureanu, Ravi Radhakrishnan, Yuko Tsutsui, Robert Perttilä, Franziska Preuss, Ketan Malhotra, Wilhelmiina Niininen, Steven Stayrook, Krishna Suresh, Joshua B. Sheetz, Sebastian Mathea, Hanna Karvonen, Mark A. Lemmon
Publikováno v:
Mol Cell
Despite their apparent lack of catalytic activity, pseudokinases are essential signaling molecules. Here, we describe the structural and dynamic properties of pseudokinase domains from the Wnt-binding receptor tyrosine kinases (PTK7, ROR1, ROR2, and
Autor:
Hendrik Paysen, Raluca M. Fratila, Jesús M. de la Fuente, Thithawat Trakoolwilaiwan, Nguyen T. K. Thanh, Norbert Löwa, Staffan Hildebrand, Alexander Pfeifer, Stephanie Franziska Preuss, Frank Wiekhorst, Zheming Niu, Georgios Kasparis, Laia Reverte-Salisa, Olaf Kosch
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Lipids are a major source of energy for most tissues, and lipid uptake and storage is therefore crucial for energy homeostasis. So far, quantification of lipid uptake in vivo has primarily relied on radioactive isotope labeling, exposing human subjec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546808bff52e50e5f7894eea53a53919
http://zaguan.unizar.es/record/109065
http://zaguan.unizar.es/record/109065