Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Franziska M. Uhl"'
Autor:
Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, Patrick Metzger, Fengshen Kuo, Désirée Schönenberger, Mojca Adlesic, Asin Peighambari, Philipp Seidel, Chia-yi Chen, Miguel Consenza-Contreras, Andreas Jud, Bernd Lahrmann, Niels Grabe, Danijela Heide, Franziska M. Uhl, Timothy A. Chan, Justus Duyster, Robert Zeiser, Christoph Schell, Mathias Heikenwalder, Oliver Schilling, A. Ari Hakimi, Melanie Boerries, Ian J. Frew
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that
Externí odkaz:
https://doaj.org/article/c9223cd55c18449db9d005eb65c4887e
Autor:
Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3
Externí odkaz:
https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5
Autor:
Eileen Haring, Geoffroy Andrieux, Franziska M. Uhl, Máté Krausz, Michele Proietti, Barbara Sauer, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Annette Schmitt-Graeff, Justus Duyster, Natalie Köhler, Bodo Grimbacher, Melanie Boerries, Konrad Aumann, Robert Zeiser, Petya Apostolova
Publikováno v:
Haematologica, Vol 107, Iss 7 (2021)
Acute graft-versus-host disease (GvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), a potentially curative treatment for leukemia. Endoplasmic reticulum (ER) stress occurs when the protein folding ca
Externí odkaz:
https://doaj.org/article/3798a575b63446ca8e0e75508ae07a3d
Autor:
Eileen Haring, Franziska M. Uhl, Geoffroy Andrieux, Michele Proietti, Alla Bulashevska, Barbara Sauer, Lukas M. Braun, Enrique de Vega Gomez, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Marie Follo, Annette Schmitt-Graeff, Joerg Buescher, Justus Duyster, Bodo Grimbacher, Melanie Boerries, Erika L. Pearce, Robert Zeiser, Petya Apostolova
Publikováno v:
Haematologica, Vol 106, Iss 8 (2020)
Acute graft-versus-host disease causes significant mortality in patients undergoing allogeneic hematopoietic cell transplantation. Immunosuppressive treatment for graft-versus-host disease can impair the beneficial graft-versus-leukemia effect and fa
Externí odkaz:
https://doaj.org/article/63bfd079d0904bb389c7f5bf30a08018
Autor:
Máté Krausz, Justus Duyster, Bodo Grimbacher, Geoffroy Andrieux, Robert Zeiser, Stefan F. Martin, Franziska M. Uhl, Dietmar Pfeifer, Barbara Sauer, Natalie Köhler, Eileen Haring, Konrad Aumann, Annette Schmitt-Graeff, Petya Apostolova, Philipp R. Esser, Melanie Boerries, Michele Proietti
Publikováno v:
Haematologica. 107:1538-1554
Acute graft-versus-host disease (GvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), a potentially curative treatment for leukemia. Endoplasmic reticulum (ER) stress occurs when the protein folding ca
Autor:
Shaima’a Hamarsheh, Justus Duyster, Lukas Braun, Franziska M. Uhl, Sandra Duquesne, Geoffroy Andrieux, Robert Zeiser, Melanie Boerries, Annette Schmitt-Graeff, Lena Osswald, Christine Dierks, Tilman Brummer, Claudius Klein
Publikováno v:
Molecular Cancer Research. 19:1596-1608
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic RAS mutations, causing constitutive activation of multiple tumor-promoting pathways, are frequently found in human cancer. So far in hemat
Autor:
Lukas Braun, Erika L. Pearce, Bodo Grimbacher, Annette Schmitt-Graeff, Franziska M. Uhl, Dietmar Pfeifer, Barbara Sauer, Melanie Boerries, Joerg M. Buescher, Enrique de Vega Gomez, Justus Duyster, Geoffroy Andrieux, Stefan F. Martin, Robert Zeiser, Alla Bulashevska, Petya Apostolova, Michele Proietti, Philipp R. Esser, Eileen Haring, Marie Follo
Publikováno v:
Haematologica
Acute graft-versus-host disease causes significant mortality in patients undergoing allogeneic hematopoietic cell transplantation. Immunosuppressive treatment for graft-versus-host disease can impair the beneficial graft-versus-leukemia effect and fa
Autor:
David, O'Sullivan, Michal A, Stanczak, Matteo, Villa, Franziska M, Uhl, Mauro, Corrado, Ramon I, Klein Geltink, David E, Sanin, Petya, Apostolova, Nisha, Rana, Joy, Edwards-Hicks, Katarzyna M, Grzes, Agnieszka M, Kabat, Ryan L, Kyle, Mario, Fabri, Jonathan D, Curtis, Michael D, Buck, Annette E, Patterson, Annamaria, Regina, Cameron S, Field, Francesc, Baixauli, Daniel J, Puleston, Edward J, Pearce, Robert, Zeiser, Erika L, Pearce
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fever is a common symptom of infections and inflammation. We observed CD8+ T cells exposed to febrile-range temperature during activation, augmented mitochondrial mass, and metabolic activity. An adoptive transfer of these cells into tum
Autor:
Michael D. Buck, Daniel J. Puleston, Mario Fabri, Agnieszka M. Kabat, Katarzyna M. Grzes, Annamaria Regina, Michal A. Stanczak, Francesc Baixauli, Annette E. Patterson, Erika L. Pearce, Ryan Kyle, Joy Edwards-Hicks, Robert Zeiser, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, David O’Sullivan, Jonathan D. Curtis, Cameron S. Field, Edward J. Pearce, Franziska M. Uhl, Matteo Villa, Mauro Corrado, Nisha Rana
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show that in activated CD8+ T cells, exposure to febril
Autor:
Franziska M. Uhl, Ulrike Burk, Shuofei Cheng, Sandra Braun, Sebastian Halbach, Tilman Brummer, Manuel Lauinger, Thomas Reinheckel, Nadine Reischmann, Martin Köhler, Sophia Ehrenfeld, Kathrin Ringwald, Robert Zeiser, Natalie Köhler, Christoph Peters, Corinna Spohr
Publikováno v:
Oncogene. 38:1324-1339
Copy number gains, point mutations and epigenetic silencing events are increasingly observed in genes encoding elements of the Ras/Raf/MEK/ERK signaling axis in human breast cancer. The three Raf kinases A-Raf, B-Raf, and Raf-1 have an important role