Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Franziska M. Ippen"'
Autor:
Franziska M. Ippen, Katharina Schregel, Matthias Ungerer, Manuel Feisst, Peter A. Ringleb, Christoph K. Gumbinger
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundEndovascular thrombectomy (EVT) reduces disability in patients with acute ischemic stroke (AIS); however, its efficacy in patients aged >80 years remains unclear.ObjectivesThis study aimed to assess the impact of premorbid modified Rankin S
Externí odkaz:
https://doaj.org/article/93d0e8f1a09f49cbb504ead02533b414
Autor:
Priscilla K. Brastianos, Hiroaki Wakimoto, Daniel P. Cahill, Scott L. Carter, Maria Martinez-Lage, Anita Giobbie-Hurder, Megha Subramanian, Jianfang Ning, Gregory R. Wojtkiewicz, Stephen P. Schmidt, Tristan Penson, Matthew Lastrapes, Ivanna V. Bihun, Alexandria L. Fink, Benjamin M. Kuter, Christopher A. Alvarez-Breckenridge, Franziska M. Ippen
Western blot analysis of p-p44/42 MAPK (Erk1/2) (Thr202/Tyr204), p-MEK1/2 (Ser217/221), p-p90RSK (Ser380), p-MSK1 (Thr581) in JIMT-1 BR-3, MDA-MB-361, MDA-MB-231 BrM2 and BS-004 cell lines treated with GDC-0084 in increasing concentrations for a tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc25e6af1c18a10c51316128945a202
https://doi.org/10.1158/1078-0432.22470510.v1
https://doi.org/10.1158/1078-0432.22470510.v1
Autor:
Priscilla K. Brastianos, Hiroaki Wakimoto, Daniel P. Cahill, Scott L. Carter, Maria Martinez-Lage, Anita Giobbie-Hurder, Megha Subramanian, Jianfang Ning, Gregory R. Wojtkiewicz, Stephen P. Schmidt, Tristan Penson, Matthew Lastrapes, Ivanna V. Bihun, Alexandria L. Fink, Benjamin M. Kuter, Christopher A. Alvarez-Breckenridge, Franziska M. Ippen
Purpose:Previous studies have shown that the PI3K/Akt/mTOR pathway is activated in up to 70% of breast cancer brain metastases, but there are no approved agents for affected patients. GDC-0084 is a brain penetrant, dual PI3K/mTOR inhibitor that has s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4462a59ba850ac6cd3caddecb662fc76
https://doi.org/10.1158/1078-0432.c.6527592
https://doi.org/10.1158/1078-0432.c.6527592
Autor:
Priscilla K. Brastianos, Hiroaki Wakimoto, Daniel P. Cahill, Scott L. Carter, Maria Martinez-Lage, Anita Giobbie-Hurder, Megha Subramanian, Jianfang Ning, Gregory R. Wojtkiewicz, Stephen P. Schmidt, Tristan Penson, Matthew Lastrapes, Ivanna V. Bihun, Alexandria L. Fink, Benjamin M. Kuter, Christopher A. Alvarez-Breckenridge, Franziska M. Ippen
Photomicrographs illustrating p-MEK1/2 (Ser221) and p-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) expression in mouse brains harboring either JIMT-1 BR-3 or MDA-MB-231 BrM2 intracranial tumors, stratified by treatment with sham or GDC-0084.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe3b839cacdc04735a7be46993e31f4
https://doi.org/10.1158/1078-0432.22470504.v1
https://doi.org/10.1158/1078-0432.22470504.v1
Autor:
Priscilla K. Brastianos, Hiroaki Wakimoto, Daniel P. Cahill, Scott L. Carter, Maria Martinez-Lage, Anita Giobbie-Hurder, Megha Subramanian, Jianfang Ning, Gregory R. Wojtkiewicz, Stephen P. Schmidt, Tristan Penson, Matthew Lastrapes, Ivanna V. Bihun, Alexandria L. Fink, Benjamin M. Kuter, Christopher A. Alvarez-Breckenridge, Franziska M. Ippen
GDC-0084-induced changes in cell cycle in the PIK3CA-mutant cell line MDA-MB-361 and in the PIK3CA-wildtype cell line BS-004
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a4ca0d25b0649bebbb06ee5469fa58
https://doi.org/10.1158/1078-0432.22470507.v1
https://doi.org/10.1158/1078-0432.22470507.v1
Autor:
Scott L. Carter, Juan Carlos Martinez-Gutierrez, Tracy T. Batchelor, Ibiayi Dagogo-Jack, Christopher Alvarez-Breckenridge, Priscilla K. Brastianos, Sun Ha Paek, Michael White, Benjamin Kaufman, Kaitlin Hoang, Nicholas D. Camarda, Daniel P. Cahill, Megan R. D'Andrea, Anna S. Berghoff, Mia Bertalan, Parker H. Merrill, Darrell R. Borger, Sun Hye Park, Devin McCabe, Sandro Santagata, Deepika Nagabhushan, Franziska M. Ippen, A. John Iafrate, Matthew R. Strickland, Ryan P. Frazier, Naema Nayyar, Matthew Lastrapes, Ivanna Bihun, Emily Batchelor, Elisa Aquilanti, Maria Martinez-Lage, Brandyn A. Castro, Ben Kuter, Matthias Preusser, Matthew P. Frosch, Magali De Sauvage, David Shih, Andrew Kaneb, Bruce E. Johnson, Alexander Kaplan, Ugonma Chukwueke, Elizabeth R. Gerstner, Corey M. Gill
Publikováno v:
Nature Genetics. 52:371-377
Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality. To identify genomic alterations that promote brain metastases, we performed whole-exome sequencing of 73 BM-LUAD cases. Using case-control analyses, we discovered
Autor:
Björn Reuter, Michael Daffertshofer, Christoph Gumbinger, Matthias N. Ungerer, Christian Stock, Ingo Bruder, Franziska M. Ippen, Peter A. Ringleb
Publikováno v:
Neurology. 93:e1834-e1843
BackgroundIt is common practice to withhold IV thrombolysis (IVT) for acute ischemic stroke in patients with preexisting disabilities. To test the hypothesis of an association of IVT and good clinical outcome also in patients with preexisting disabil
Autor:
Simon Nagel, Christoph Gumbinger, Christian Hametner, Jan C. Purrucker, Franziska M. Ippen, Fabian Walter, Sibu Mundiyanapurath
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Frontiers in Neurology
Frontiers in Neurology
Background: Transient ischemic attack (TIA) needs further diagnostic evaluation to prevent future ischemic stroke. However, prophylaxis can be harmful in elderly if the diagnosis is wrong. We aimed at characterizing differences in TIA mimics in young
Autor:
Elisa Aquilanti, Helen D’Couto, Priscilla K. Brastianos, Franziska M. Ippen, Julia Katharina Grosch
Publikováno v:
Central Nervous System Metastases ISBN: 9783030234164
Brain metastases are a devastating secondary complication of systemic cancer and account for the most common central nervous system (CNS) neoplasm in adult cancer patients [1]. Improved systemic therapies and the advancement of neuroimaging technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6c6ba71afd4a0947a8937692772b5da
https://doi.org/10.1007/978-3-030-23417-1_4
https://doi.org/10.1007/978-3-030-23417-1_4
Autor:
Juan Carlos Martinez-Gutierrez, Michael White, Elizabeth R. Gerstner, Corey M. Gill, Darrell R. Borger, Benjamin Kaufman, Kaitlin Hoang, Scott L. Carter, Ibiayi Dagogo-Jack, Naema Nayyar, Sandro Santagata, Daniel P. Cahill, Tracy T. Batchelor, Matthias Preusser, Megan R. D'Andrea, Ivanna Bihun, Franziska M. Ippen, Priscilla K. Brastianos, A. John Iafrate, Maria Martinez-Lage, Emily Batchelor, Devin McCabe, Ryan P. Frazier, Anna S. Berghoff, Matthew Lastrapes, Parker H. Merrill, Matthew R. Strickland, Christopher Alvarez-Breckenridge, Sung Hye Park, Deepika Nagabhushan, Mia Bertalan, Sun Ha Paek, Nicholas D. Camarda, Elisa Aquilanti, David Shih, Andrew Kaneb, Benjamin M. Kuter, Bruce E. Johnson, Alexander Kaplan, Ugonma Chukwueke, Brandyn A. Castro, Matthew P. Frosch, Magali De Sauvage
Publikováno v:
Neuro Oncol
Although lung adenocarcinomas frequently metastasize to the brain, treatment options for lung adenocarcinoma brain metastases are limited. We discovered novel candidate drivers of progression by using case-control analyses to compare whole-exome sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915dfc923d2cb6aec985d8f72e27a732
https://europepmc.org/articles/PMC6847560/
https://europepmc.org/articles/PMC6847560/