Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Franziska Koser"'
Autor:
Felix A. Trogisch, Franziska Koser, Synje Michel, David A. Liem, Bogdan I. Florea, Markus Hecker, Oliver Drews
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Proteasome degradation is an integral part of cellular growth and function. Proteasomal intervention may mitigate adverse myocardial remodeling, but is associated with the onset of heart failure. Previously, we have demonstrated that increasing abund
Externí odkaz:
https://doaj.org/article/b394b1c743274c74866ccda3685ce473
Autor:
Yong Li, Anthony L Hessel, Andreas Unger, David Ing, Jannik Recker, Franziska Koser, Johanna K Freundt, Wolfgang A Linke
Publikováno v:
eLife, Vol 9 (2020)
The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quanti
Externí odkaz:
https://doaj.org/article/14e6d313415849ec9d8bc171ea89d6f9
Autor:
Ross C. Bretherton, Isabella M. Reichardt, Kristin A. Zabrecky, Alex J. Goldstein, Logan R.J. Bailey, Darrian Bugg, Timothy S. McMillen, Kristina B. Kooiker, Galina V. Flint, Amy Martinson, Jagdambika Gunaje, Franziska Koser, Elizabeth Plaster, Wolfgang A. Linke, Michael Regnier, Farid Moussavi-Harami, Nathan J. Sniadecki, Cole A. DeForest, Jennifer Davis
Publikováno v:
bioRxiv
Inherited mutations in contractile and structural genes, which decrease cardiomyocyte tension generation, are principal drivers of dilated cardiomyopathy (DCM)– the leading cause of heart failure1,2. Progress towards developing precision therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d6d727242a076bceeee75ea3108274
https://europepmc.org/articles/PMC9900749/
https://europepmc.org/articles/PMC9900749/
Autor:
Franziska Koser, Anastasia J. Hobbach, Mahmoud Abdellatif, Viktoria Herbst, Clara Türk, Holger Reinecke, Marcus Krüger, Simon Sedej, Wolfgang A. Linke
Publikováno v:
Life sciences. 309
Despite the high prevalence of heart failure with preserved ejection fraction (HFpEF), the pathomechanisms remain elusive and specific therapy is lacking. Disease-causing factors include metabolic risk, notably obesity. However, proteomic changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cb49ef1740dea5a9ad576717c66a08
https://pubmed.ncbi.nlm.nih.gov/36179815
https://pubmed.ncbi.nlm.nih.gov/36179815
Autor:
Franziska Koser, Mahmoud Abdellatif, Clara Türk, Anastasia J. Hobbach, Holger Reinecke, Marcus Krüger, Simon Sedej, Wolfgang Linke
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:16-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce24724cec39299d5bd55394b68c28a8
https://doi.org/10.1016/j.yjmcc.2022.08.034
https://doi.org/10.1016/j.yjmcc.2022.08.034
Autor:
Jan Gummert, Anna Hucke, Alexander Goedel, Astrid Kassner, Hendrik Milting, Izabela Tuleta, Wolfgang A. Linke, Andrey Fomin, Katrin Streckfuß-Bömeke, Anna Gärtner, Norbert Hubner, Holger Reinecke, Cristobal G. dos Remedios, Lina Folsche, Alessandra Moretti, Ralph Knöll, Gerd Hasenfuss, Katharina Sielemann, Sebastiaan van Heesch, Luisa Wellers, Malte Tiburcy, Anastasia J. Hobbach, Lukas Cyganek, Wolfram H. Zimmermann, Franziska Koser, Karl-Ludwig Laugwitz, Andreas Unger, Marion von Frieling-Salewsky
Publikováno v:
Science Translational Medicine. 13
Stable expression of truncated titin proteins and titin haploinsufficiency characterize TTN cardiomyopathy and represent targets for therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a191aabca65731cb00a94038bff0f52d
https://doi.org/10.1126/scitranslmed.abd3079
https://doi.org/10.1126/scitranslmed.abd3079
Autor:
Andrey, Fomin, Anna, Gärtner, Lukas, Cyganek, Malte, Tiburcy, Izabela, Tuleta, Luisa, Wellers, Lina, Folsche, Anastasia J, Hobbach, Marion, von Frieling-Salewsky, Andreas, Unger, Anna, Hucke, Franziska, Koser, Astrid, Kassner, Katharina, Sielemann, Katrin, Streckfuß-Bömeke, Gerd, Hasenfuss, Alexander, Goedel, Karl-Ludwig, Laugwitz, Alessandra, Moretti, Jan F, Gummert, Cristobal G, Dos Remedios, Holger, Reinecke, Ralph, Knöll, Sebastiaan, van Heesch, Norbert, Hubner, Wolfram H, Zimmermann, Hendrik, Milting, Wolfgang A, Linke
Publikováno v:
Science translational medicine. 13(618)
Heterozygous truncating variants in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69b2bb236f5a569e431a7bbe506f056b
https://pubmed.ncbi.nlm.nih.gov/34799709
https://pubmed.ncbi.nlm.nih.gov/34799709
Autor:
Anna Hucke, Anna Gärtner, Marion von Frieling-Salewski, Andreas Unger, Franziska Koser, Michael Regnier, Karl Toischer, Hendrik Milting, Wolfgang Linke
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9e1bb8b06ef7aa40c3100d829cd4f18
https://doi.org/10.1016/j.yjmcc.2022.08.144
https://doi.org/10.1016/j.yjmcc.2022.08.144
Publikováno v:
The Febs Journal
Titin is a giant elastic protein expressed in the contractile units of striated muscle cells, including the sarcomeres of cardiomyocytes. The last decade has seen enormous progress in our understanding of how titin molecular elasticity is modulated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16413872e3dec6cb4860ec996e471521
https://doi.org/10.1111/febs.14854
https://doi.org/10.1111/febs.14854
Autor:
Clara Türk, Chintan N. Koyani, Rui Adão, Simon Sedej, Francisco Vasques-Nóvoa, Tobias Pendl, Andreas Zirlik, Christian Mühlfeld, Lavinia Rech, Guido Kroemer, Akos Heinemann, Senka Ljubojevic-Holzer, Martina Auer, Wolfgang A. Linke, Julia Voglhuber, Daniel Scherr, Saša Frank, Johanna K. Freundt, Viktoria Trummer-Herbst, Julia Kargl, Stefan Kiechl, Sylvère Durand, Elías Herrero-Galán, Nathaly Anto-Michel, Adelino F. Leite-Moreira, Christina Brandenberger, Jorge Alegre-Cebollada, Albrecht Schmidt, Julia von Maltzahn, Frank Madeo, Julia Schipke, Michael Kasa, Andreas Prokesch, Mahmoud Abdellatif, Franziska Koser, Renate Schreiber, Sebastian J. Hofer, Fanny Aprahamian, André P. Lourenço, Tobias Eisenberg, Maria-Rosaria Pricolo, Peter P. Rainer, Dirk von Lewinski, Marcus Krüger
Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we show that diastolic dysfunction in patients with HFpEF is associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5104be3b590ba341ba8b7fae30597fd5
https://hdl.handle.net/20.500.12105/15164
https://hdl.handle.net/20.500.12105/15164