Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Franziska K. Geis"'
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-10 (2022)
Abstract Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such defense is the transcriptional silencing of incoming viral DNA, including the silencing of unintegrated retroviral DNA in
Externí odkaz:
https://doaj.org/article/0b0bbd2762c34bc188de206b36e464ac
Autor:
Yvonne Knopp, Franziska K. Geis, Dirk Heckl, Stefan Horn, Thomas Neumann, Johannes Kuehle, Janine Meyer, Boris Fehse, Christopher Baum, Michael Morgan, Johann Meyer, Axel Schambach, Melanie Galla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 256-274 (2018)
The recently discovered CRISPR/Cas9 system is widely used in basic research and is a useful tool for disease modeling and gene editing therapies. However, long-term expression of DNA-modifying enzymes can be associated with cytotoxicity and is partic
Externí odkaz:
https://doaj.org/article/2595b6871a8e4673b10f1cd8093290c6
Autor:
Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff, Axel Schambach
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-15 (2017)
Abstract Background Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or less permissive to retro
Externí odkaz:
https://doaj.org/article/90f7e4752ff0410b8c88e36b068c3079
Autor:
Franziska K. Geis, Stephen P. Goff
Publikováno v:
Viruses, Vol 12, Iss 8, p 884 (2020)
Almost half of the human genome is made up of transposable elements (TEs), and about 8% consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous retrovirus infections of the germ line. Most TEs are inactive and not detriment
Externí odkaz:
https://doaj.org/article/b0caba9d8cc840beabd2ec4ab7db5bde
Autor:
Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff, Axel Schambach
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-1 (2017)
Abstract The authors wish to apologize for an error within the scale bar of the microarray heatmap in Additional File 5 of the supplementary information. Two values were incorrectly displayed on the scale bar (11 instead of 10 and 13 instead of 12).
Externí odkaz:
https://doaj.org/article/468caf7c20f94eb6a420a81544380f41
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Invading viral DNAs constitute a high risk for the infected cell and are high-profile targets of antiviral host factors. Nevertheless, little is known about the silencing machinery in the nucleus that acts to prevent transcription or ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba6da69a1a408851b05a04898371b02
https://pubmed.ncbi.nlm.nih.gov/35074917
https://pubmed.ncbi.nlm.nih.gov/35074917
Publikováno v:
Retrovirology. 19(1)
Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such defense is the transcriptional silencing of incoming viral DNA, including the silencing of unintegrated retroviral DNA in most cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bd944b85a11950566beaec79d7f0ca
https://pubmed.ncbi.nlm.nih.gov/35810297
https://pubmed.ncbi.nlm.nih.gov/35810297
Autor:
Boris Fehse, Johann Meyer, Yvonne Knopp, Stefan Horn, Johannes Kuehle, Dirk Heckl, Michael A. Morgan, Franziska K. Geis, Thomas Neumann, Melanie Galla, Axel Schambach, Janine Meyer, Christopher Baum
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 256-274 (2018)
Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 256-274 (2018)
The recently discovered CRISPR/Cas9 system is widely used in basic research and is a useful tool for disease modeling and gene editing therapies. However, long-term expression of DNA-modifying enzymes can be associated with cytotoxicity and is partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b90b33d467d8dc86e1ebc9dda37896
https://doi.org/10.1016/j.omtn.2018.09.006
https://doi.org/10.1016/j.omtn.2018.09.006
Autor:
Franziska K. Geis, Stephen P. Goff
Publikováno v:
Proc Natl Acad Sci U S A
Upon delivery into the nucleus of the host cell, linear double-stranded retroviral DNAs are either integrated into the host genome to form the provirus or act as a target of the DNA damage response and become circularized. Little is known about the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468b17b6dedbafe089f9aa14e7ad816b
https://europepmc.org/articles/PMC6876238/
https://europepmc.org/articles/PMC6876238/
Autor:
Dirk Hoffmann, Axel Schambach, Christine Goffinet, Daniela Zychlinski, Melanie Galla, Stephen P. Goff, Franziska K. Geis, Johannes Kuehle, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer
Publikováno v:
Retrovirology
Retrovirology, Vol 14, Iss 1, Pp 1-1 (2017)
Retrovirology, Vol 14, Iss 1, Pp 1-1 (2017)
Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or less permissive to retrovirus infection due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e354c78e5c79b1f2baaa8e78ff48f0
http://europepmc.org/articles/PMC5648417
http://europepmc.org/articles/PMC5648417