Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Franziska Hettler"'
Autor:
Markus Schick, Le Zhang, Sabine Maurer, Hans Carlo Maurer, Konstandina Isaakaidis, Lara Schneider, Upayan Patra, Kathrin Schunck, Elena Rohleder, Julia Hofstetter, Apoorva Baluapuri, Anna Katharina Scherger, Julia Slotta-Huspenina, Franziska Hettler, Julia Weber, Thomas Engleitner, Roman Maresch, Jolanta Slawska, Richard Lewis, Rouzanna Istvanffy, Stefan Habringer, Katja Steiger, Armin Baiker, Robert A. J. Oostendorp, Cornelius Miething, Hans-Peter Lenhof, Florian Bassermann, Björn Chapuy, Matthias Wirth, Elmar Wolf, Roland Rad, Stefan Müller, Ulrich Keller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
SUMOylation is a post-translational modification that has been shown to be altered in cancer. Here, the authors show that loss of the SUMO isopeptidase SENP6 leads to unrestricted SUMOylation and genomic instability promoting lymphomagenesis and gene
Externí odkaz:
https://doaj.org/article/ba5bc46837534430996429dd0c309256
Autor:
Franziska Hettler, Christina Schreck, Sandra Romero Marquez, Thomas Engleitner, Baiba Vilne, Theresa Landspersky, Heike Weidner, Renate Hausinger, Ritu Mishra, Rupert Oellinger, Martina Rauner, Ronald Naumann, Christian Peschel, Florian Bassermann, Roland Rad, Rouzanna Istvanffy, Robert A.J. Oostendorp
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Remodeling of the bone marrow microenvironment in chronic inflammation and in aging reduces hematopoietic stem cell (HSC) function. To assess the mechanisms of this functional decline of HSC and find strategies to counteract it, we established a mode
Externí odkaz:
https://doaj.org/article/942464b251af43739fad8007d14f664c
Autor:
Renate Hausinger, Marianne Hackl, Ana Jardon Alvarez, Miriam Kehr, Sandra Romero Marquez, Franziska Hettler, Christian Kehr, Sandra Grziwok, Christina Schreck, Christian Peschel, Rouzanna Istvánffy, Robert A. J. Oostendorp
Publikováno v:
Immunity, Inflammation and Disease, Vol 9, Iss 2, Pp 521-532 (2021)
Abstract In this study, we investigated the influence of the loss of cathepsin K (Ctsk) gene on the hematopoietic system in vitro and in vivo. We found that cultures with lineage− SCA1+ KIT+ (LSK) cells on Ctsk deficient stromal cells display reduc
Externí odkaz:
https://doaj.org/article/dbdacb8b9eb74afd8f5bc33fc9befd35
Autor:
Sandra Romero Marquez, Franziska Hettler, Renate Hausinger, Christina Schreck, Theresa Landspersky, Lynette Henkel, Corinne Angerpointner, Ihsan E. Demir, Matthias Schiemann, Florian Bassermann, Katharina S. Götze, Rouzanna Istvánffy, Robert A.J. Oostendorp
Publikováno v:
Haematologica, Vol 106, Iss 10 (2020)
Hematopoietic stem cell self-renewal, proliferation, and differentiation are independently regulated by intrinsic as well as extrinsic mechanisms. We previously demonstrated that murine proliferation of hematopoietic stem cells is supported in serum-
Externí odkaz:
https://doaj.org/article/28765a9c0043475c9d111cfead5dd74c
Autor:
Dirk Strunk, Terry P Yamaguchi, Sandra Romero Marquez, Rouzanna Istvanffy, Michèle C. Buck, Jennifer Rivière, Katharina Brandstetter, Franziska Hettler, Matthias Kieslinger, Akiko Shimamura, Florian Bassermann, Mehmet Sacma, Hartmut Geiger, Erik Hameister, Jürgen Ruland, Christina Schreck, Heinrich Leonhardt, Theresa Landspersky, Robert A.J. Oostendorp, Judith S. Hecker, Kasiani C. Myers, Matthias Schiemann, Marilena Götz, Romina Ludwig, Martin Wolf, Katharina Götze
Publikováno v:
Blood
The cellular mechanisms required to ensure homeostasis of the hematopoietic niche and the ability of this niche to support hematopoiesis upon stress remain elusive. We here identify Wnt5a in Osterix+ mesenchymal progenitor and stem cells (MSPCs) as a
Autor:
Robert Oostendorp, Wolfgang Enard, Katharina Götze, Hartmut Geiger, Johanna Geuder, Judith Hecker, Franziska Hettler, Theresa Landspersky, Sandra Romero Marquez, Mehmet Sacma, Christina Schreck, Mareike verbeek
Publikováno v:
Experimental Hematology. 111:S122-S123
Autor:
Lynette Henkel, Sandra Romero Marquez, Rouzanna Istvanffy, Christina Schreck, Theresa Landspersky, Robert A.J. Oostendorp, Matthias Schiemann, Ihsan Ekin Demir, Franziska Hettler, Renate Hausinger, Corinne Angerpointner, Katharina Götze, Florian Bassermann
Publikováno v:
Haematologica
Hematopoietic stem cell self-renewal, proliferation, and differentiation are independently regulated by intrinsic as well as extrinsic mechanisms. We previously demonstrated that murine proliferation of hematopoietic stem cells is supported in serum-
Autor:
Robert Oostendorp, Florian Bassermann, Franziska Hettler, Rouzanna Istvanffy, Theresa Landspersky, Ronald Naumann, Sandra Romero Marquez, Christina Schreck
Publikováno v:
Experimental Hematology. 111:S122
Autor:
Christina Schreck, Katharina Brandstetter, Jennifer Beauvarlet, Florian Bassermann, Franziska Hettler, Heinrich Leonhardt, Katharina Götze, Erik Hameister, Sandra Romero Marquez, Theresa Sippenauer, Terry P Yamaguchi, Rouzanna Istvanffy, Robert A.J. Oostendorp
Publikováno v:
Experimental Hematology. 88:S48-S49
The support of hematopoiesis declines with age and it was previously shown that aging hematopoietic cells show cytoskeletal deregulation. Also, efficient autophagy is required to maintain cellular functions with age. Here, we describe a new mouse mod
Autor:
Rouzanna Istvanffy, Franziska Koller, Franziska Hettler, Ekin Demir, Sandra Romero Marquez, Christina Schreck, Florian Bassermann, Robert A.J. Oostendorp, Theresa Sippenauer
Publikováno v:
Experimental Hematology. 88:S31
We have previously found that a Sfrp1 knock-out environment fails to support the regeneration of hematopoetic stem cells (HSC) with serial to repopulate secondary recipients Renstrom et al., [1] . In order to dissect cell specific requirements of the