Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response

Autor: Franziska Gsottberger, Christina Meier, Anna Ammon, Scott Parker, Kerstin Wendland, Rebekka George, Srdjan Petkovic, Lisa Mellenthin, Charlotte Emmerich, Gloria Lutzny-Geier, Markus Metzler, Andreas Mackensen, Vidyalakshmi Chandramohan, Fabian Müller

Publikováno v: Cell Death and Disease, Vol 14, Iss 8, Pp 1-13 (2023)

Abstract Cellular stress responses including the unfolded protein response (UPR) decide over the fate of an individual cell to ensure survival of the entire organism. During physiologic UPR counter-regulation, protective proteins are upregulated to p

Externí odkaz: https://doaj.org/article/15b35ae762b44e4bbd9c25c7e5e42184

Triton X-114 and Amine-Based Wash Strategy Reduces Lipopolysaccharides to FDA Limit and Achieves Purer, More Potent Recombinant Immunotoxin

Autor: Franziska Gsottberger, Fabian Müller, Lisa Mellenthin, Anna Ammon, Kerstin Wendland, Andreas Mackensen, Rebekka George

Publikováno v: Bioconjugate Chemistry. 32:713-720

Many proteins are still routinely expressed prokaryotically in Escherichia coli, some because they are toxic to eukaryotes. Immunotoxins, which are fusion proteins of a targeting moiety and a trunc...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041564df90fcd35060dcb79f1000d214
https://doi.org/10.1021/acs.bioconjchem.1c00013

Human CD22-Transgenic, Primary Murine Lymphoma Challenges Immunotherapies in Organ-Specific Tumor Microenvironments

Autor: Charlotte Emmerich, Carol Geppert, Ramona Erber, Fabian Müller, Franziska Gsottberger, Arndt Hartmann, Kerstin Wendland, Srdjan Petkovic, Lars Nitschke, Andreas Mackensen, Carolin Brandl

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10433, p 10433 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

Targeted immunotherapies have greatly changed treatment of patients with B cell malignancies. To further enhance immunotherapies, research increasingly focuses on the tumor microenvironment (TME), which differs considerably by organ site. However, im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ac128646382f0c4721860f1b7cbec7
https://www.mdpi.com/1422-0067/22/19/10433