Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Franziska Blaeschke"'
Autor:
Franziska Blaeschke, Dana Stenger, Antonia Apfelbeck, Bruno L. Cadilha, Mohamed-Reda Benmebarek, Jasmin Mahdawi, Eva Ortner, Mareike Lepenies, Nicola Habjan, Felicitas Rataj, Semjon Willier, Theresa Kaeuferle, Robbie G. Majzner, Dirk H. Busch, Sebastian Kobold, Tobias Feuchtinger
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 6, Pp 1-6 (2021)
Externí odkaz:
https://doaj.org/article/af275a1b5c7a4ccfad9a71a7c9aa4002
Autor:
Nicole Cordes, Carolin Kolbe, Dominik Lock, Tatjana Holzer, Deborah Althoff, Daniel Schäfer, Franziska Blaeschke, Bettina Kotter, Sandra Karitzky, Claudia Rossig, Toni Cathomen, Tobias Feuchtinger, Iris Bürger, Mario Assenmacher, Thomas Schaser, Andrew D. Kaiser
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 42-53 (2021)
Recently, a rare type of relapse was reported upon treating a B cell acute lymphoblastic leukemia (B-ALL) patient with anti-CD19 chimeric antigen receptor (CAR)-T cells caused by unintentional transduction of residual malignant B cells (CAR-B cells).
Externí odkaz:
https://doaj.org/article/c35a2ae8e0aa4f12be416e571f892b51
Autor:
Franziska Blaeschke, Eva Ortner, Dana Stenger, Jasmin Mahdawi, Antonia Apfelbeck, Nicola Habjan, Tanja Weißer, Theresa Kaeuferle, Semjon Willier, Sebastian Kobold, Tobias Feuchtinger
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Therapeutic targeting of inhibitory checkpoint molecules in combination with chimeric antigen receptor (CAR) T cells is currently investigated in a variety of clinical studies for treatment of hematologic and solid malignancies. However, the impact o
Externí odkaz:
https://doaj.org/article/854adee3aa3543c4b4bbd7ad61959e1a
Autor:
Dasmanthie De Silva, Lucas Ferguson, Grant H Chin, Benjamin E Smith, Ryan A Apathy, Theodore L Roth, Franziska Blaeschke, Marek Kudla, Alexander Marson, Nicholas T Ingolia, Jamie HD Cate
Publikováno v:
eLife, Vol 10 (2021)
Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here, we show human translation initiation factor eIF3 interacts with se
Externí odkaz:
https://doaj.org/article/fdd3a25c8ef34dc58d680270a363a4b5
Autor:
Semjon Willier, Karin Melanie Cabanillas Stanchi, Martina von Have, Vera Binder, Franziska Blaeschke, Judith Feucht, Tobias Feuchtinger, Michaela Döring
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Chemotherapy-induced nausea and vomiting (CINV) belong among the most burdensome side effects in hemato-oncology. Mostly, a combination of ondansetron and dexamethasone is used as antiemetic prophylaxis in pediatric patients under
Externí odkaz:
https://doaj.org/article/40dde7f3da78498c81cb29aeb9c1fa59
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background Allogeneic hematopoietic stem cell transplantation (HSCT) can expose patients to a transient but marked immunosuppression, during which viral infections are an important cause of morbidity and mortality. Adoptive transfer of virus
Externí odkaz:
https://doaj.org/article/0a306c3437d34157adfd1c0bcaaafd8b
Autor:
Rachel L. Rutishauser, Christian Deo T. Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L. Roth, Lynn Wang, Kyle A. Raymond, Carly E. Starke, Joseph C. Mudd, Wenxuan Chen, Carolyn Smullin, Rodrigo Matus-Nicodemos, Rebecca Hoh, Melissa Krone, Frederick M. Hecht, Christopher D. Pilcher, Jeffrey N. Martin, Richard A. Koup, Daniel C. Douek, Jason M. Brenchley, Rafick-Pierre Sékaly, Satish K. Pillai, Alexander Marson, Steven G. Deeks, Joseph M. McCune, Peter W. Hunt
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco
Externí odkaz:
https://doaj.org/article/1a92cd130be447828fcd995ae89a3b10
Autor:
Armin Wolf, Semjon Willier, Johannes Raedler, Franziska Blaeschke, Dana Stenger, Montserrat Pazos Escudero, Florian Jurgeleit, Thomas G P Grünewald, Vera Binder, Irene Schmid, Michael H Albert, Tobias Feuchtinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Relapsed/refractory B-precursor acute lymphoblastic leukemia (BCP-ALL) remains a major therapeutic challenge in pediatric hematology. Chimeric antigen receptor (CAR) T cells targeting CD19 have shown remarkable initial response rates in BC
Externí odkaz:
https://doaj.org/article/27c8b25d5ad94f20ab2fed383e907a26
Autor:
Michaela C. Baldauf, Julia S. Gerke, Andreas Kirschner, Franziska Blaeschke, Manuel Effenberger, Kilian Schober, Rebeca Alba Rubio, Takayuki Kanaseki, Merve M. Kiran, Marlene Dallmayer, Julian Musa, Nurset Akpolat, Ayse N. Akatli, Fernando C. Rosman, Özlem Özen, Shintaro Sugita, Tadashi Hasegawa, Haruhiko Sugimura, Daniel Baumhoer, Maximilian M. L. Knott, Giuseppina Sannino, Aruna Marchetto, Jing Li, Dirk H. Busch, Tobias Feuchtinger, Shunya Ohmura, Martin F. Orth, Uwe Thiel, Thomas Kirchner, Thomas G. P. Grünewald
Publikováno v:
OncoImmunology, Vol 7, Iss 9 (2018)
Immunotherapy can revolutionize anti-cancer therapy if specific targets are available. Immunogenic peptides encoded by cancer-specific genes (CSGs) may enable targeted immunotherapy, even of oligo-mutated cancers, which lack neo-antigens generated by
Externí odkaz:
https://doaj.org/article/fe2207c4008c460db2d92b4dc1887c16
Autor:
Uwe Thiel, Sebastian J. Schober, Ingo Einspieler, Andreas Kirschner, Melanie Thiede, David Schirmer, Katja Gall, Franziska Blaeschke, Oxana Schmidt, Susanne Jabar, Andreas Ranft, Rebeca Alba Rubío, Uta Dirksen, Thomas G. P. Grunewald, Poul H. Sorensen, Günther H. S. Richter, Irene Teichert von Lüttichau, Dirk H. Busch, Stefan E. G. Burdach
Publikováno v:
OncoImmunology, Vol 6, Iss 5 (2017)
Background: Chondromodulin-I (CHM1) sustains malignancy in Ewing sarcoma (ES). Refractory ES carries a dismal prognosis and patients with bone marrow (BM) metastases do not survive irrespective of therapy. We assessed HLA-A*02:01/CHM1-specific allore
Externí odkaz:
https://doaj.org/article/3cc9a9d7f65440adbaafa92d0d5289d0