Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Franziska A. Mandl"'
Autor:
Stephan A. Sieber, Manfred Rohde, Mathias W. Hackl, Eva Medina, Vadim S. Korotkov, Elena Kunold, Franziska A. Mandl, William M. Wuest, Christian Fetzer, Robert Macsics, Philipp Le, Maria Reinecke, Bernhard Kuster, Johannes Lehmann, Diego Chaves-Moreno, Katharina Rox, Stephan M. Hacker, Dietmar H. Pieper, Iris Antes, Megan C. Jennings, Ilke Ugur
Publikováno v:
Nature chemistry
International
United States
England
International
United States
England
New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sorafenib as major hit that effe
Publikováno v:
Angewandte Chemie. 130:14642-14682
Publikováno v:
Angewandte Chemie International Edition. 57:14440-14475
The public view on antibiotics as reliable medicines changed when reports about "resistant superbugs" appeared in the news. While reasons for this resistance development are easily spotted, solutions for re-establishing effective antibiotics are stil
Publikováno v:
ACS Chemical Biology. 13:2016-2019
Reactive oxygen species (ROS) play an important role in the onset of Parkinson's disease (PD), and deciphering protective mechanisms is a major goal for therapeutic development. Here, DJ-1 (PARK7) gained major attention when a conserved cysteine resi
Autor:
Franziska A. Mandl, Stephan A. Sieber, Klaus Richter, Ilke Ugur, Christian Fetzer, Iris Antes, Jan Vomacka, Volker C. Kirsch, Thilo M. Fuchs, Sabine Schneider, Elena Kunold
Publikováno v:
Angewandte Chemie International Edition. 55:14852-14857
Gram-negative bacteria represent a challenging task for antibacterial drug discovery owing to their impermeable cell membrane and restricted uptake of small molecules. We herein describe the synthesis of natural-product-derived epoxycyclohexenones an
Autor:
Elena Kunold, Klaus Richter, Ilke Ugur, Iris Antes, Jan Vomacka, Volker C. Kirsch, Stephan A. Sieber, Franziska A. Mandl, Thilo M. Fuchs, Christian Fetzer, Sabine Schneider
Publikováno v:
Angewandte Chemie. 128:15074-15079
Aufgrund ihrer undurchlassigeren Zellmembran und der damit verbundenen eingeschrankten Aufnahme von niedermolekularen Verbindungen stellen Gram-negative Bakterien eine grose Herausforderung fur die Entwicklung neuer Antibiotika dar. Hier wurden natur
Publikováno v:
Chemistry - A European Journal. 21:3701-3707
Natural products represent a rich source of bioactive compounds that constitute a large fraction of approved drugs. Among those are molecules with electrophilic scaffolds, such as Michael acceptors, β-lactams, and epoxides that irreversibly inhibit
Autor:
Stephan A. Sieber, Armin R. Ofial, Franziska A. Mandl, Christian Ochsenfeld, Elija N. Wiedemann, Iris D. Blank
Publikováno v:
ChemPlusChem. 80(11)
Natural products comprise a rich source for bioactive molecules with medicinal relevance. Many of these contain electrophilic scaffolds that bind conserved enzyme active sites covalently. Prominent examples include beta-lactams and beta-lactones, whi