Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration

Autor: Rodrigo Herrera-Molina, Kristina Mlinac-Jerkovic, Katarina Ilic, Franziska Stöber, Sampath Kumar Vemula, Mauricio Sandoval, Natasa Jovanov Milosevic, Goran Simic, Karl-Heinz Smalla, Jürgen Goldschmidt, Svjetlana Kalanj Bognar, Dirk Montag

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract The cell adhesion molecule neuroplastin (Np) is a novel candidate to influence human intelligence. Np-deficient mice display complex cognitive deficits and reduced levels of Plasma Membrane Ca2+ ATPases (PMCAs), an essential regulator of the

Externí odkaz: https://doaj.org/article/242c8b715c3a4890a78cba8ca5160c63

Neuroplastin expression is essential for hearing and hair cell PMCA expression

Autor: Andrew W. Curran, Maike Vollmer, Rodrigo Herrera-Molina, Franziska Stöber, Xiao Lin, Eckart D. Gundelfinger, Max F. K. Happel, Michael G. K. Brunk, Jürgen Goldschmidt, Enqi Zhang, PingAn Yuanxiang, Dirk Montag

Publikováno v: Brain structure & function, 226(5):1533-1551
Brain Structure & Function

Hearing deficits impact on the communication with the external world and severely compromise perception of the surrounding. Deafness can be caused by particular mutations in the neuroplastin (Nptn) gene, which encodes a transmembrane recognition mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5674984c91e7d62462ad4dd22114c500
https://doi.org/10.1007/s00429-021-02269-w

Proof of Therapeutic Efficacy of a 177Lu-Labeled Neurotensin Receptor 1 Antagonist in a Colon Carcinoma Xenograft Model

Autor: Martin Rohracker, Christiane Smerling, Holger Amthauer, Aileen Höhne, Jürgen Goldschmidt, Anette Pethe, Mercedes Noriega, Ulrich Reineke, Marvin Stiebler, Jörg Schulz, Frank Osterkamp, Mathias Lukas, Franziska Stöber

Publikováno v: Journal of Nuclear Medicine. 58:936-941

Increased expression of neurotensin receptor 1 (NTR1) has been shown in a large number of tumor entities such as pancreatic or colon carcinoma. Hence, this receptor is a promising target for diagnostic imaging and radioligand therapy. Using the favor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c490a9fee3ccf56b901a6cb975baadc
https://doi.org/10.2967/jnumed.116.185140

Metabolic brain networks in aging and preclinical Alzheimer's disease

Autor: William J. Jagust, Gil D. Rabinovici, Sharada Narayan, Katelyn L. Arnemann, Franziska Stöber

Publikováno v: NeuroImage : Clinical
NeuroImage: Clinical, Vol 17, Iss, Pp 987-999 (2018)
Arnemann, KL; Stöber, F; Narayan, S; Rabinovici, GD; & Jagust, WJ. (2018). Metabolic brain networks in aging and preclinical Alzheimer's disease. NeuroImage: Clinical, 17, 987-999. doi: 10.1016/j.nicl.2017.12.037. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7kk5248k

Metabolic brain networks can provide insight into the network processes underlying progression from healthy aging to Alzheimer's disease. We explore the effect of two Alzheimer's disease risk factors, amyloid-β and ApoE ε4 genotype, on metabolic br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a7f118affcf28d0aa5dcf78fba39cc
https://escholarship.org/uc/item/7kk5248k

Proof of Therapeutic Efficacy of a

Autor: Jörg, Schulz, Martin, Rohracker, Marvin, Stiebler, Jürgen, Goldschmidt, Franziska, Stöber, Mercedes, Noriega, Anette, Pethe, Mathias, Lukas, Frank, Osterkamp, Ulrich, Reineke, Aileen, Höhne, Christiane, Smerling, Holger, Amthauer

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 58(6)

Increased expression of neurotensin receptor 1 (NTR1) has been shown in a large number of tumor entities such as pancreatic or colon carcinoma. Hence, this receptor is a promising target for diagnostic imaging and radioligand therapy. Using the favor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e238eca8b92e8fdc525bf56a093188d8
https://pubmed.ncbi.nlm.nih.gov/28254866