Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Franziska, Boess"'
Autor:
Benjamin Berger, Massimiliano Donzelli, Swarna Maseneni, Franziska Boess, Adrian Roth, Stephan Krähenbühl, Manuel Haschke
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Currently used hepatocyte cell systems for in vitro assessment of drug metabolism include hepatoma cell lines and primary human hepatocyte (PHH) cultures. We investigated the suit-ability of the validated in vivo Basel phenotyping cocktail (caffeine
Externí odkaz:
https://doaj.org/article/d26b41a9ef8d4a8792f7f576e5048f28
Autor:
Sabine Sewing, Franziska Boess, Annie Moisan, Cristina Bertinetti-Lapatki, Tanja Minz, Maj Hedtjaern, Yann Tessier, Franz Schuler, Thomas Singer, Adrian B Roth
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159431 (2016)
Single stranded oligonucleotides (SSO) represent a novel therapeutic modality that opens new space to address previously undruggable targets. In spite of their proven efficacy, the development of promising SSO drug candidates has been limited by repo
Externí odkaz:
https://doaj.org/article/cc5d924443744c99be2c142b2f6b51f5
Autor:
Ramona Nudischer, Sabine Sewing, Adrian Roth, Barbara M. Elcombe, Andreas Hierlemann, Nicholas Flint, Jean-Christophe Hoflack, Kasper Renggli, Lykke Pedersen, Franziska Boess, Barbara Lenz, Simone Schadt, Cristina Bertinetti-Lapatki, Larry G. Higgins, Audrey Vardy, Laurent Gand
Publikováno v:
Toxicological Sciences. 176:329-342
Basimglurant (RG7090), a small molecule under development to treat certain forms of depression, demonstrated foci of altered hepatocytes in a long-term rodent-toxicity study. Additional evidence pointed toward the activation of the constitutive andro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eae93021c5d77cd1759a967c46923ab
https://doi.org/10.1093/toxsci/kfaa076
https://doi.org/10.1093/toxsci/kfaa076
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-1 (2017)
Externí odkaz:
https://doaj.org/article/ac7a729a7c1147f2bc01eab5fd437055
Autor:
Josephine Schmaler, Mohammed Ullah, Franziska Boess, Birgit Molitor, Aynur Ekiciler, Alexandre Durrwell, Isabelle Walter, Brian Leonard, Nicole A. Kratochwil, Giorgio Ottaviani, Russell Jones, Charles Alexandre Tournillac, Florian Klammers, Yuyan Jin, Neil Parrott, Martina B. Mueller, Dan Turley, Stephen Fowler, Michaela Marschmann, Pierre-Alexis Gonsard, Miriam Triyatni
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:237-248
Long-term in vitro liver models are now widely explored for human hepatic metabolic clearance prediction, enzyme phenotyping, cross-species metabolism, comparison of low clearance drugs, and induction studies. Here, we present studies using a long-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58a3bb7e1d0e52e6b59ad6ff7a653e7
https://doi.org/10.1124/jpet.117.245712
https://doi.org/10.1124/jpet.117.245712
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2036
The mechanisms of antisense oligonucleotide-induced liver toxicity are still poorly understood. Assessment of the hepatic safety profile is currently mostly investigated directly in rodent studies. A predictive preclinical in vitro model that is capt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1dcf5c0563c34dc62d2fb788bc826d75
https://pubmed.ncbi.nlm.nih.gov/31410802
https://pubmed.ncbi.nlm.nih.gov/31410802
Publikováno v:
Methods in Molecular Biology ISBN: 9781493996698
The mechanisms of antisense oligonucleotide-induced liver toxicity are still poorly understood. Assessment of the hepatic safety profile is currently mostly investigated directly in rodent studies. A predictive preclinical in vitro model that is capt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c746cf29e940bdbe70646b43f6d19d7
https://doi.org/10.1007/978-1-4939-9670-4_15
https://doi.org/10.1007/978-1-4939-9670-4_15
Publikováno v:
Drug Metabolism and Disposition. 44:560-569
The nonsteroidal androgen-receptor antagonist flutamide is associated with hepatic injury. Oxidative stress and reactive metabolite formation are considered contributing factors to liver toxicity. Here we have used flutamide as a model drug to study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac46e1d9e191dfac341ed40ea6ff6b99
https://doi.org/10.1124/dmd.115.066522
https://doi.org/10.1124/dmd.115.066522
Autor:
Laura Suter, Thomas Weiser, Andreas Buness, Franziska Boess, M. Watzele, Stefan Kustermann, Thomas Singer, M. Schmitz, Adrian Roth
Publikováno v:
Toxicology in Vitro. 27:1589-1595
Cell-based assays are key tools in drug safety assessment. However, they usually provide only limited information about time-kinetics of a toxic effect and implementing multiple measurements is often complex. To overcome these issues we established a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b041e9a280311c629e1de00ba1855573
https://doi.org/10.1016/j.tiv.2012.08.019
https://doi.org/10.1016/j.tiv.2012.08.019
Autor:
Jitao David Zhang, Juergen Funk, Simon Bassett, Thomas Singer, Adrian Roth, Franziska Boess, Barbara Lenz, Urs Niederhauser
Publikováno v:
Toxicology. 379
Foci of altered hepatocytes (FAH) are considered putative, pre-neoplastic lesions that can occur spontaneously in aging rodents, but can also be induced by chemicals or drugs. Progression of FAH to hepatocellular neoplasms has been reported repeatedl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db68937ef1b296090c40c530602d51f5
https://pubmed.ncbi.nlm.nih.gov/28174063
https://pubmed.ncbi.nlm.nih.gov/28174063