Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Franz X Gruber"'
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179700 (2017)
Targeted inhibition of the oncogenic BCR-ABL1 fusion protein using the ABL1 tyrosine kinase inhibitor imatinib has become standard therapy for chronic myelogenous leukemia (CML), with most patients reaching total and durable remission. However, a sig
Externí odkaz:
https://doaj.org/article/818e28afe7614f7ca4c50361c9f4503f
Autor:
Thoralf Lange, Thomas Ernst, Franz X. Gruber, Jacqueline Maier, Michael Cross, Martin C. Müller, Dietger Niederwieser, Andreas Hochhaus, Markus Pfirrmann
Publikováno v:
Haematologica, Vol 98, Iss 5 (2013)
The BCR-ABL T315I mutation causes resistance to imatinib, nilotinib and dasatinib in chronic myeloid leukemia. Forty BCR-ABL positive patients with imatinib resistance were analyzed for T315I mutated clones after six months on nilotinib or dasatinib
Externí odkaz:
https://doaj.org/article/eded32b8a0524c109668b1e62bc5ee98
Autor:
Thomas Ernst, Franz X. Gruber, Oliver Pelz-Ackermann, Jacqueline Maier, Markus Pfirrmann, Martin C. Müller, Ingvild Mikkola, Kimmo Porkka, Dietger Niederwieser, Andreas Hochhaus, Thoralf Lange
Publikováno v:
Haematologica, Vol 94, Iss 9 (2009)
Background Various techniques have been employed to detect BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia who are resistant to imatinib. This has led to different reported frequencies of mutations and the finding of a heter
Externí odkaz:
https://doaj.org/article/8780bb4cfcb644fb88c8f91f1b727968
Autor:
Ingvild Mikkola, Martin C. Müller, Dietger Niederwieser, Jaqueline Maier, Thomas Ernst, Thoralf Lange, Franz X Gruber, Andreas Hochhaus, Kimmo Porkka
Publikováno v:
Blood. 112:2127-2127
BCR-ABL kinase domain (KD) mutations are the major mechanism of acquired imatinib resistance in patients (pts) with chronic myeloid leukemia (CML). Second generation tyrosine kinase inhibitors (TKI) are effective against most imatinib resistance muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8930b707443cbca094e4fe931e612dd2
https://doi.org/10.1182/blood.v112.11.2127.2127
https://doi.org/10.1182/blood.v112.11.2127.2127