Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Franz Schilling"'
Autor:
Carolin Kitzberger, Khuram Shehzad, Volker Morath, Rebekka Spellerberg, Julius Ranke, Katja Steiger, Roland E. Kälin, Gabriele Multhoff, Matthias Eiber, Franz Schilling, Rainer Glass, Wolfgang A. Weber, Ernst Wagner, Peter J. Nelson, Christine Spitzweg
Publikováno v:
Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 238-253 (2023)
New treatment strategies are urgently needed for glioblastoma (GBM)—a tumor resistant to standard-of-care treatment with a high risk of recurrence and extremely poor prognosis. Based on their intrinsic tumor tropism, adoptively applied mesenchymal
Externí odkaz:
https://doaj.org/article/d524b87cfd2b4c978c114bf543db85aa
Autor:
Martin Grashei, Pascal Wodtke, Jason G. Skinner, Sandra Sühnel, Nadine Setzer, Thomas Metzler, Sebastian Gulde, Mihyun Park, Daniela Witt, Hermine Mohr, Christian Hundshammer, Nicole Strittmatter, Natalia S. Pellegata, Katja Steiger, Franz Schilling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-13C2]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerpri
Externí odkaz:
https://doaj.org/article/e47e9472da1b44daad591e0e237537be
Autor:
Luca Nagel, Martin Gierse, Wolfgang Gottwald, Zumrud Ahmadova, Martin Grashei, Pascal Wolff, Felix Josten, Senay Karaali, Christoph A. Müller, Sebastian Lucas, Jochen Scheuer, Christoph Müller, John Blanchard, Geoffrey J. Topping, Andre Wendlinger, Nadine Setzer, Sandra Sühnel, Jonas Handwerker, Christophoros Vassiliou, Frits H.A. vanHeijster, Stephan Knecht, Michael Keim, Franz Schilling, Ilai Schwartz
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of curr
Externí odkaz:
https://doaj.org/article/4196ad2bd6bc458db0ea54a94f53f55f
Autor:
Marshall L. Deline, Joshua Straub, Manisha Patel, Pratigya Subba, Martin Grashei, Frits H. A. van Heijster, Philip Pirkwieser, Veronika Somoza, James D. Livingstone, Michael Beazely, Brian Kendall, Michel J. P. Gingras, Zoya Leonenko, Carmen Höschen, Gertraud Harrington, Katharina Kuellmer, Wangqing Bian, Franz Schilling, Matthew P. A. Fisher, Matthew E. Helgeson, Tobias Fromme
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Lithium is commonly prescribed as a mood stabilizer in a variety of mental health conditions, yet its molecular mode of action is incompletely understood. Many cellular events associated with lithium appear tied to mitochondrial function. Further, re
Externí odkaz:
https://doaj.org/article/6fbfdea63e2642778ba9809e357f3dc0
Autor:
Irina Heid, Corinna Münch, Sinan Karakaya, Smiths S. Lueong, Alina M. Winkelkotte, Sven T. Liffers, Laura Godfrey, Phyllis F. Y. Cheung, Konstantinos Savvatakis, Geoffrey J. Topping, Florian Englert, Lukas Kritzner, Martin Grashei, Andrea Tannapfel, Richard Viebahn, Heiner Wolters, Waldemar Uhl, Deepak Vangala, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Daniel Rauh, Wilko Weichert, Jörg D. Hoheisel, Stephan A. Hahn, Franz Schilling, Rickmer Braren, Marija Trajkovic-Arsic, Jens T. Siveke
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) lacks effective treatment options beyond chemotherapy. Although molecular subtypes such as classical and QM (quasi-mesenchymal)/basal-like with transcriptome-based distinct signatures have b
Externí odkaz:
https://doaj.org/article/bde08f1443834615a3f9cb25e23e0e2b
Autor:
Rebekka Spellerberg, Teoman Benli-Hoppe, Carolin Kitzberger, Mara Hageneier, Nathalie Schwenk, Özgür Öztürk, Katja Steiger, Gabriele Multhoff, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Roland E. Kälin, Rainer Glass, Peter J. Nelson, Ernst Wagner, Christine Spitzweg
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 272-287 (2022)
Sodium iodide symporter (NIS) gene transfer for active accumulation of iodide in tumor cells is a powerful theranostic strategy facilitating both diagnostic and therapeutic application of radioiodide. In glioblastoma (GBM), the blood-brain barrier (B
Externí odkaz:
https://doaj.org/article/a363261d210f4561be309e89accd3fb1
Autor:
Carolin Kitzberger, Rebekka Spellerberg, Volker Morath, Nathalie Schwenk, Kathrin A. Schmohl, Christina Schug, Sarah Urnauer, Mariella Tutter, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Sibylle Ziegler, Peter Bartenstein, Ernst Wagner, Peter J. Nelson, Christine Spitzweg
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in non-thyroidal tumors followed
Externí odkaz:
https://doaj.org/article/7399ed72a2d84c20be101a3d6215c0fb
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Background Hyperpolarization enhances the sensitivity of nuclear magnetic resonance experiments by between four and five orders of magnitude. Several hyperpolarized sensor molecules have been introduced that enable high sensitivity detection
Externí odkaz:
https://doaj.org/article/5956e60d0eeb4c8cb5bfafe6b99e0d42
Autor:
Hermine Mohr, Alessia Foscarini, Katja Steiger, Simone Ballke, Christoph Rischpler, Franz Schilling, Natalia S. Pellegata
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Pheochromocytomas (PCCs) and paragangliomas (PGLs), together referred to as PPGLs, are rare chromaffin cell-derived tumors. They require timely diagnosis as this is the only way to achieve a cure through surgery and because of the potentiall
Externí odkaz:
https://doaj.org/article/c4fbcb4bf080461b9d0980047642c50a
Autor:
Rebekka Spellerberg, Teoman Benli-Hoppe, Carolin Kitzberger, Simone Berger, Kathrin A. Schmohl, Nathalie Schwenk, Hsi-Yu Yen, Christian Zach, Franz Schilling, Wolfgang A. Weber, Roland E. Kälin, Rainer Glass, Peter J. Nelson, Ernst Wagner, Christine Spitzweg
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 432-446 (2021)
Lipo-oligomers, post-functionalized with ligands to enhance targeting, represent promising new vehicles for the tumor-specific delivery of therapeutic genes such as the sodium iodide symporter (NIS). Due to its iodide trapping activity, NIS is a powe
Externí odkaz:
https://doaj.org/article/a21a2ee7289e45db862f0ab82f5abc16