Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Franz S Gruber"'
Autor:
Franz S Gruber, Anthony Richardson, Zoe C Johnston, Rachel Myles, Neil R Norcross, David P Day, Irene Georgiou, Laura Sesma-Sanz, Caroline Wilson, Kevin D Read, Sarah Martins da Silva, Christopher L R Barratt, Ian H Gilbert, Jason R Swedlow
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297666 (2024)
Male contraceptive options and infertility treatments are limited, and almost all innovation has been limited to updates to medically assisted reproduction protocols and methods. To accelerate the development of drugs that can either improve or inhib
Externí odkaz:
https://doaj.org/article/f2f5d29a721e4ad38c065b5e3404a1c2
Autor:
Romina Piscitello-Gómez, Franz S Gruber, Abhijeet Krishna, Charlie Duclut, Carl D Modes, Marko Popović, Frank Jülicher, Natalie A Dye, Suzanne Eaton
Publikováno v:
eLife, Vol 12 (2023)
How morphogenetic movements are robustly coordinated in space and time is a fundamental open question in biology. We study this question using the wing of Drosophila melanogaster, an epithelial tissue that undergoes large-scale tissue flows during pu
Externí odkaz:
https://doaj.org/article/d2869b5bc22e4346a05e4198b39f0167
Publikováno v:
eLife, Vol 9 (2020)
There is an urgent need to develop new methods for male contraception, however a major barrier to drug discovery has been the lack of validated targets and the absence of an effective high-throughput phenotypic screening system. To address this defic
Externí odkaz:
https://doaj.org/article/ff8909f58458495680b57381786e13f9
Autor:
Franz S. Gruber, Anthony Richardson, Zoe C. Johnston, Rachel Myles, Neil Norcross, David Day, Irene Georgiou, Laura Sesma Sanz, Caroline Wilson, Kevin D. Read, Sarah Martins da Silva, Christopher L. R. Barratt, Ian H. Gilbert, Jason R. Swedlow
Male contraceptive options and infertility treatments are limited. To help overcome these limitations we established a small molecule library as a toolbox for assay development and screening campaigns using human spermatozoa. We have profiled all com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1f8a71fa8e5a4846798fbbccf07f3af
https://doi.org/10.1101/2023.05.02.539126
https://doi.org/10.1101/2023.05.02.539126
Autor:
Zoe C Johnston, Franz S Gruber, Sean G Brown, Neil R Norcross, Jason Swedlow, Ian H Gilbert, Christopher L R Barratt
Publikováno v:
Reproduction. 163:R1-R9
Despite recent advances in male reproductive health research, there remain many elements of male infertility where our understanding is incomplete. Consequently, diagnostic tools and treatments for men with sperm dysfunction, other than medically ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c3cdc8c42bf735f0bf15888dad18ae
https://doi.org/10.1530/rep-21-0372
https://doi.org/10.1530/rep-21-0372
Autor:
Romina Piscitello-Gómez, Franz S Gruber, Abhijeet Krishna, Charlie Duclut, Carl D Modes, Marko Popović, Frank Jülicher, Natalie A Dye, Suzanne Eaton
How morphogenetic movements are robustly coordinated in space and time is a fundamental open question in biology. We study this question using the wing ofDrosophila melanogaster, an epithelial tissue that undergoes large-scale tissue flows during pup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef80f349e5b9597113f3e7194ce5f4c3
https://doi.org/10.1101/2022.12.09.519799
https://doi.org/10.1101/2022.12.09.519799
Autor:
Neil R. Norcross, Irene Georgiou, Zoe C. Johnston, Franz S. Gruber, Jason R. Swedlow, Kevin D. Read, Christopher LR. Barratt, Ian H. Gilbert
Publikováno v:
European journal of medicinal chemistry. 243
There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ced93c8d835649047f8d729d5ad37cb
https://pubmed.ncbi.nlm.nih.gov/36087385
https://pubmed.ncbi.nlm.nih.gov/36087385
Autor:
Jason R. Swedlow, I. Georgiou, Kevin D. Read, Franz S. Gruber, Christopher L.R. Barratt, S. Martins de Silva, Ian H. Gilbert, Neil R. Norcross, Caroline Wilson, Zoe C. Johnston
Publikováno v:
Human reproduction (Oxford, England). 37(3)
STUDY QUESTION Can a high-throughput screening (HTS) platform facilitate male fertility drug discovery? SUMMARY ANSWER An HTS platform identified a large number of compounds that enhanced sperm motility. WHAT IS KNOWN ALREADY Several efforts to find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4502af83cfe004ff4190508c1ea34989
https://pubmed.ncbi.nlm.nih.gov/35048946
https://pubmed.ncbi.nlm.nih.gov/35048946
Autor:
Ivan Dikic, Rachel Toth, Sven M. Lange, Stephen P. Matthews, Isobel Cole, Paul G. Wyatt, Virginia Dee Cesare, Franz S. Gruber, Anthony G. Hope, Fraser Cunningham, Lee A. Armstrong, Denisa Bojkova, Yogesh Kulathu, Rukmini Mukherjee, Raja Sekhar Nirujogi, David W. Gray, Paul Davies, Jindrich Cinatl
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253364 (2021)
PLoS ONE
PLoS ONE
Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle. Being a large, multidomain, transmembrane protein, Nsp3 has been the most challenging Nsp to characterize. Encoded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd32b1ded91543c9a2151942185c437
https://doaj.org/article/7e4e63d2ba344215bb01a64466ff2cc4
https://doaj.org/article/7e4e63d2ba344215bb01a64466ff2cc4
Autor:
Stephen P. Matthews, Ivan Dikic, Sven M. Lange, Anthony G. Hope, Lee A. Armstrong, David W. Gray, Denisa Bojkova, Rukmini Mukherjee, Fraser Cunningham, Virginia De Cesare, Paul G. Wyatt, Yogesh Kulathu, Isobel Cole, Jindrich Cinatl, Paul Davies, Rachel Toth, Raja Sekar Nirujogi, Franz S. Gruber
Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle. Being a large, multidomain, transmembrane protein, Nsp3 has been the most challenging Nsp to characterize. Encoded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bd0a0e19e4267684017754347d32cd
https://doi.org/10.1101/2020.12.09.417741
https://doi.org/10.1101/2020.12.09.417741