Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Franz P W, Radner"'
Autor:
Laura Pajed, Ulrike Taschler, Anna Tilp, Peter Hofer, Petra Kotzbeck, Stephanie Kolleritsch, Franz P. W. Radner, Isabella Pototschnig, Carina Wagner, Margarita Schratter, Sandra Eder, Sabrina Huetter, Renate Schreiber, Guenter Haemmerle, Thomas O. Eichmann, Martina Schweiger, Gerald Hoefler, Erin E. Kershaw, Achim Lass, Gabriele Schoiswohl
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Pajed et al. investigate the role of adipocyte hormone-sensitive lipase (HSL) in whole body energy homeostasis. They show that adipocyte-specific HSL Knockout (AHKO) mice fed high fat diet develop fatty liver. Interestingly, this phenotype reverses i
Externí odkaz:
https://doaj.org/article/489219dde80844a090448c922d5f0fbd
Publikováno v:
Metabolites, Vol 12, Iss 11, p 1015 (2022)
The α/β-Hydrolase domain-containing protein 5 (ABHD5; also known as comparative gene identification-58, or CGI-58) is the causative gene of the Chanarin-Dorfman syndrome (CDS), a disorder mainly characterized by systemic triacylglycerol accumulatio
Externí odkaz:
https://doaj.org/article/3b11d410a9e9417f913aadc44683e55c
Autor:
Gernot F. Grabner, Nikolaus Guttenberger, Nicole Mayer, Anna K. Migglautsch-Sulzer, Christian Lembacher-Fadum, Nermeen Fawzy, Dominik Bulfon, Peter Hofer, Thomas Züllig, Lennart Hartig, Natalia Kulminskaya, Gabriel Chalhoub, Margarita Schratter, Franz P. W. Radner, Karina Preiss-Landl, Sarah Masser, Achim Lass, Rudolf Zechner, Karl Gruber, Monika Oberer, Rolf Breinbauer, Robert Zimmermann
Publikováno v:
Journal of the American Chemical Society. 144(14)
Chronically elevated circulating fatty acid levels promote lipid accumulation in nonadipose tissues and cause lipotoxicity. Adipose triglyceride lipase (ATGL) critically determines the release of fatty acids from white adipose tissue, and accumulatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9667abe7b8e208351783e5895f0ec5e7
https://pubmed.ncbi.nlm.nih.gov/35362954
https://pubmed.ncbi.nlm.nih.gov/35362954
Autor:
Franz P. W. Radner, Slaheddine Marrakchi, Peter Kirchmeier, Gwang-Jin Kim, Florence Ribierre, Bourane Kamoun, Leila Abid, Michael Leipoldt, Hamida Turki, Werner Schempp, Roland Heilig, Mark Lathrop, Judith Fischer
Publikováno v:
PLoS Genetics, Vol 9, Iss 6 (2013)
Externí odkaz:
https://doaj.org/article/a4dfe7cb25674ce28820d9c2acb3da8b
Autor:
Franz P W Radner, Slaheddine Marrakchi, Peter Kirchmeier, Gwang-Jin Kim, Florence Ribierre, Bourane Kamoun, Leila Abid, Michael Leipoldt, Hamida Turki, Werner Schempp, Roland Heilig, Mark Lathrop, Judith Fischer
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003536 (2013)
Autosomal recessive congenital ichthyosis (ARCI) is a rare genetic disorder of the skin characterized by abnormal desquamation over the whole body. In this study we report four patients from three consanguineous Tunisian families with skin, eye, hear
Externí odkaz:
https://doaj.org/article/eb205806975848f0bae15868d1c06749
Autor:
Laura Pajed, Ulrike Taschler, Anna Tilp, Peter Hofer, Petra Kotzbeck, Stephanie Kolleritsch, Franz P. W. Radner, Isabella Pototschnig, Carina Wagner, Margarita Schratter, Sandra Eder, Sabrina Huetter, Renate Schreiber, Guenter Haemmerle, Thomas O. Eichmann, Martina Schweiger, Gerald Hoefler, Erin E. Kershaw, Achim Lass, Gabriele Schoiswohl
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Modulation of adipocyte lipolysis represents an attractive approach to treat metabolic diseases. Lipolysis mainly depends on two enzymes: adipose triglyceride lipase and hormone-sensitive lipase (HSL). Here, we investigated the short- and long-term i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::528a0384d75b761be2b4b45761d61151
https://pubmed.ncbi.nlm.nih.gov/33692445
https://pubmed.ncbi.nlm.nih.gov/33692445
Autor:
Andreas, Elentner, Matthias, Schmuth, Nikolaos, Yannoutsos, Thomas O, Eichmann, Robert, Gruber, Franz P W, Radner, Martin, Hermann, Barbara, Del Frari, Sandrine, Dubrac
Publikováno v:
The Journal of investigative dermatology
The skin is in daily contact with environmental pollutants, but the long-term effects of such exposure remain underinvestigated. Many of these toxins bind and activate the pregnane X receptor (PXR), a ligand-activated transcription factor that regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::730c7a17e3d4537c983bef62596e1345
http://europepmc.org/articles/PMC6217923
http://europepmc.org/articles/PMC6217923
Autor:
Benedikt, Kien, Susanne, Grond, Guenter, Haemmerle, Achim, Lass, Thomas O, Eichmann, Franz P W, Radner
Publikováno v:
Journal of Lipid Research
Mutations in the genes coding for patatin-like phospholipase domain-containing 1 (PNPLA1) and α/β-hydrolase domain-containing 5 (ABHD5), also known as comparative gene identification 58, are causative for ichthyosis, a severe skin barrier disorder.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7c571ef8a75c4199d1ce1936199c9aa
https://pubmed.ncbi.nlm.nih.gov/30361410
https://pubmed.ncbi.nlm.nih.gov/30361410
Autor:
Ariane R, Pessentheiner, Katharina, Huber, Helmut J, Pelzmann, Andreas, Prokesch, Franz P W, Radner, Heimo, Wolinski, Josefine, Lindroos-Christensen, Gerald, Hoefler, Thomas, Rülicke, Ruth, Birner-Gruenberger, Martin, Bilban, Juliane G, Bogner-Strauss
Publikováno v:
The FASEB Journal
Adipocyte plasma membrane–associated protein (APMAP) has been described as an adipogenic factor in 3T3-L1 cells with unknown biochemical function; we therefore aimed to investigate the physiologic function of APMAP in vivo. We generated Apmap-knock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53cf0fbf4a0a893b6de42a91f0623fd4
https://pubmed.ncbi.nlm.nih.gov/28559441
https://pubmed.ncbi.nlm.nih.gov/28559441
Autor:
Susanne, Grond, Thomas O, Eichmann, Sandrine, Dubrac, Dagmar, Kolb, Matthias, Schmuth, Judith, Fischer, Debra, Crumrine, Peter M, Elias, Guenter, Haemmerle, Rudolf, Zechner, Achim, Lass, Franz P W, Radner
Publikováno v:
The Journal of investigative dermatology. 137(2)
Mutations in PNPLA1 have been identified as causative for autosomal recessive congenital ichthyosis in humans and dogs. So far, the underlying molecular mechanisms are unknown. In this study, we generated and characterized PNPLA1-deficient mice and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f5bcaa67ab0d1ee0b88657b0c92bfb0
https://pubmed.ncbi.nlm.nih.gov/27751867
https://pubmed.ncbi.nlm.nih.gov/27751867