Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Franz Obermayr"'
Autor:
Doreen Schmidl, Nikolaus Hommer, Martin Kallab, Andreas Schlatter, Clemens Nadvornik, Franz Obermayr, Stefan Sperl, Eric J. Daniels, Gerhard Garhöfer
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 367 (2024)
Purpose: Inhibitors of dihydroorotate dehydrogenase (DHODH) have been found to be potent anti-inflammatory agents. Recently, a topical formulation (KIO-101 eye drops) of a DHODH inhibitor has been developed. The aim of the present study was to evalua
Externí odkaz:
https://doaj.org/article/759a9169e30740b5bc7a7f0f908c78c7
Autor:
Stephan Thurau, Christoph M. E. Deuter, Arnd Heiligenhaus, Uwe Pleyer, Joachim Van Calster, Talin Barisani-Asenbauer, Franz Obermayr, Stefan Sperl, Romana Seda-Zehetner, Gerhild Wildner
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Uveitis is a T cell-mediated, intraocular inflammatory disease and one of the main causes of blindness in industrialized countries. There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single
Externí odkaz:
https://doaj.org/article/91d5150c3bf84380ba8db090b62ca8f5
Autor:
Maria Diedrichs-Möhring, Sandy Niesik, Claudia S. Priglinger, Stephan R. Thurau, Franz Obermayr, Stefan Sperl, Gerhild Wildner
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Background Uveitis is a potentially blinding inflammatory disease of the inner eye with a high unmet need for new therapeutic interventions. Here, we wanted to investigate the suppressive effect of the intraocular application of the small mo
Externí odkaz:
https://doaj.org/article/35027cc6f0494c0a811224b2e45aa2f2
Publikováno v:
Investigative Ophthalmology & Visual Science. 56:1147-1157
Purpose We investigated the effect of PP-001, a new small molecule inhibitor of dihydro-orotate dehydrogenase in two experimental rat experimental autoimmune uveitis (EAU) models: a spontaneously relapsing-remitting model and a monophasic/chronic dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c2a93d32bdc32a45a07fd9a510a0ab
https://doi.org/10.1167/iovs.14-15518
https://doi.org/10.1167/iovs.14-15518
Autor:
Hans Lehrach, Susanne Worpenberg, Franz Obermayr, Stéphan Gasca, Bernhard G. Herrmann, Lorenz Neidhardt, Karin Wertz
Publikováno v:
Mechanisms of Development. 98(1-2):77-93
We have adapted the whole-mount in situ hybridization technique to perform high-throughput gene expression analysis in mouse embryos. A large-scale screen for genes showing specific expression patterns in the mid-gestation embryo was carried out, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217b15cac8c8185d774facfc35d76460
Autor:
Franz Obermayr, Lisa Patel, Brian P. Chadwick, Jill Williamson, Denise Sheer, Stephanie Kate Heath, Anna-Maria Frischauf
Publikováno v:
Genomics. 47:58-63
The human ninjurin gene was isolated from a cDNA library enriched for transcripts from band 9q22. A 1.2-kb message was detected for ninjurin in all human tissues studied. The full-length sequence codes for a putative 152-amino-acid protein with 89% i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bea337bb24a77c9cdd2c9dee7486fb
https://doi.org/10.1006/geno.1997.5084
https://doi.org/10.1006/geno.1997.5084
Publikováno v:
Genomics. 41:390-396
FKHL15 was isolated from a cDNA library enriched for transcripts from 9q22. Isolation and sequencing of a 3.5-kb cDNA clone identified a putative 376-amino-acid protein with greater than 80% homology over a 100-amino-acid stretch to the forkhead DNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367b7f07c1e2634f5b1d54f74be2435d
https://doi.org/10.1006/geno.1997.4692
https://doi.org/10.1006/geno.1997.4692
Autor:
Franz Obermayr, Tilo Weiss, Pia M. Gebhard, Alexander Zien, Joachim Saas, Thomas Aigner, Eckart Bartnik, Katrin Fundel, Jochen Haag, Ralf Zimmer
Publikováno v:
Arthritis and Rheumatism
Objective Despite many research efforts in recent decades, the major pathogenetic mechanisms of osteoarthritis (OA), including gene alterations occurring during OA cartilage degeneration, are poorly understood, and there is no disease-modifying treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d5fd7180f54e1802a120b68a9bbf63
https://hdl.handle.net/11858/00-001M-0000-0013-CFBD-9
https://hdl.handle.net/11858/00-001M-0000-0013-CFBD-9
Autor:
Koichi Suzuki, Bernhard Kolmerer, Hiroyuki Sorimachi, Henk Granzier, Kathleen Kunke, Karoly Trombitás, Carol C. Gregorio, Franz Obermayr, Gunter Stier, Siegfried Labeit, Thomas Centner, Bernhard G. Herrmann
Publikováno v:
Journal of Cell Biology
The Journal of Cell Biology
The Journal of Cell Biology
Titin is a giant elastic protein in vertebrate striated muscles with an unprecedented molecular mass of 3–4 megadaltons. Single molecules of titin extend from the Z-line to the M-line. Here, we define the molecular layout of titin within the Z-line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2462df567b4bd007399b68ebd45a9d1b
https://www.ncbi.nlm.nih.gov/pubmed/9817758
https://www.ncbi.nlm.nih.gov/pubmed/9817758
Publikováno v:
Genomics. 35(3)
This report describes the localization of the nuclear cap binding protein (NCBP) to human chromosome 9 and mouse chromosome 4 using somatic cell hybridization analysis. NCBP plays an important role in the splicing and transport of messenger-RNA. 11 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940e4bb696a433a262ad73730a328fcb
https://pubmed.ncbi.nlm.nih.gov/8812508
https://pubmed.ncbi.nlm.nih.gov/8812508