Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Franz M. Matschinsky"'
Autor:
Nicolai M. Doliba, Andrea V. Rozo, Jeffrey Roman, Wei Qin, Daniel Traum, Long Gao, Jinping Liu, Elisabetta Manduchi, Chengyang Liu, Maria L. Golson, Golnaz Vahedi, Ali Naji, Franz M. Matschinsky, Mark A. Atkinson, Alvin C. Powers, Marcela Brissova, Klaus H. Kaestner, Doris A. Stoffers, for the HPAP Consortium
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
BACKGROUND Multiple islet autoantibodies (AAbs) predict the development of type 1 diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in only approximately 15% of individuals who are positive for single AAbs (generally against
Externí odkaz:
https://doaj.org/article/ed4642c42951458c9cba96f40f54dcec
Autor:
David F. Wilson, Franz M. Matschinsky
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Living organisms require continuous input of energy for their existence. As a result, life as we know it is based on metabolic processes that extract energy from the environment and make it available to support life (energy metabolism). This metaboli
Externí odkaz:
https://doaj.org/article/6144a1ee4b7b4281a518bc89f59381c3
Autor:
David F. Wilson, Franz M. Matschinsky
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Nutrient delivery to the brain presents a unique challenge because the tissue functions as a computer system with in the order of 200,000 neurons/mm3. Penetrating arterioles bud from surface arteries of the brain and penetrate downward through the co
Externí odkaz:
https://doaj.org/article/efa903fe44434bbd8b009107f4121be2
Autor:
Nicolai M. Doliba, Qin Liu, Changhong Li, Pan Chen, Chengyang Liu, Ali Naji, Franz M. Matschinsky
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1240-1253 (2017)
Objectives: Chronic hyperlipidemia and hyperglycemia are characteristic features of type 2 diabetes (T2DM) that are thought to cause or contribute to β-cell dysfunction by “glucolipotoxicity.” Previously we have shown that acute treatment of pan
Externí odkaz:
https://doaj.org/article/32855ad926304bd38f411ad1b808bf91
Autor:
Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, Nicholas C. Vierra, Huiyan Lu, Yinghong Cui, Sara M. McMillin, Nicole A. Perry, Vsevolod V. Gurevich, Amy Lee, Bryan Kuo, Richard D. Leapman, Franz M. Matschinsky, Nicolai M. Doliba, Nikhil M. Urs, Marc G. Caron, David A. Jacobson, Alejandro Caicedo, Jürgen Wess
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in b
Externí odkaz:
https://doaj.org/article/66d5119437c34bdaa2ffe7d281b224eb
Autor:
Franz M. Matschinsky, David F. Wilson
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals. This includes other cells in endo
Externí odkaz:
https://doaj.org/article/e1316632d8ac417e8306b3902232b171
Autor:
Nicolai M. Doliba, Qing Liu, Changhong Li, Jie Chen, Pan Chen, Chengyang Liu, David W. Frederick, Joseph A. Baur, Michael J. Bennett, Ali Naji, Franz M. Matschinsky
Publikováno v:
Molecular Metabolism, Vol 4, Iss 12, Pp 926-939 (2015)
Objectives: Hyperglycemia and elevated blood lipids are the presumed precipitating causes of β-cell damage in T2DM as the result of a process termed “glucolipotoxicity”. Here, we tested whether glucolipotoxic pathophysiology is caused by defecti
Externí odkaz:
https://doaj.org/article/52001fcd38fa498e8ec947a39b2285c1
Autor:
David F, Wilson, Franz M, Matschinsky
Publikováno v:
International journal of molecular sciences. 23(10)
Maintaining a robust, stable source of energy for doing chemical and physical work is essential to all living organisms. In eukaryotes, metabolic energy (ATP) production and consumption occurs in two separate compartments, the mitochondrial matrix an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd8fecf86a5c8241684fcea1d9148482
https://pubmed.ncbi.nlm.nih.gov/35628359
https://pubmed.ncbi.nlm.nih.gov/35628359
Genetic activation of glucokinase in a minority of pancreatic beta cells causes hypoglycemia in mice
Autor:
Kevin H. Chen, Nicolai Doliba, Catherine L. May, Jeffrey Roman, Alessandro Ustione, Teguru Tembo, Ariel Negron, Sally Radovick, David W. Piston, Benjamin Glaser, Klaus H. Kaestner, Franz M. Matschinsky
Publikováno v:
Life Sci
AIMS: Glucokinase (GK) is expressed in the glucose-sensing cells of the islets of Langerhans and plays a critical role in glucose homeostasis. Here, we tested the hypothesis that genetic actvation of GK in a small subset of β-cells is sufficient to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe4249e253d8e5e554e660881da3dc6
https://pubmed.ncbi.nlm.nih.gov/36100080
https://pubmed.ncbi.nlm.nih.gov/36100080
Publikováno v:
Biophysical Journal. 122:203a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5db17ae49d67792b63205327dc2f2cb
https://doi.org/10.1016/j.bpj.2022.11.1225
https://doi.org/10.1016/j.bpj.2022.11.1225