Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Franz Grus"'
1
Akademický článek
Proteome alterations in aqueous humour of primary open angle glaucoma patients
Autor: Hanhan Liu, Fabian Anders, Sebastian Funke, Karl Mercieca, Franz Grus, Verena Prokosch
Publikováno v: International Journal of Ophthalmology, Vol 13, Iss 1, Pp 176-179 (2020)
AIM: To unravel the primary open angle glaucoma (POAG) related proteomic changes in aqueous humour (AH). METHODS: Totally 35 patients listed for cataract surgery (controls: n=12, age: 67.4±13.6y) or trabeculectomy for POAG (n=23, age: 72.5±8.3y) w
Externí odkaz: https://doaj.org/article/d207feada69d42139366f4c825fd0977
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2
Akademický článek
Phosphoproteome Profiling Reveals Multifunctional Protein NPM1 as part of the Irradiation Response of Tumor Cells
Autor: Nadine Wiesmann, Rita Gieringer, Franz Grus, Juergen Brieger
Publikováno v: Translational Oncology, Vol 12, Iss 2, Pp 308-319 (2019)
To fight resistances to radiotherapy, the understanding of escape mechanisms of tumor cells is crucial. The aim of this study was to identify phosphoproteins that are regulated upon irradiation. The comparative analysis of the phosphoproteome before
Externí odkaz: https://doaj.org/article/4010cabed4b14de581f1cda2a8a512c2
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3
Akademický článek
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress
Autor: Debapriya Chakraborty, Vanessa Felzen, Christof Hiebel, Elisabeth Stürner, Natarajan Perumal, Caroline Manicam, Elisabeth Sehn, Franz Grus, Uwe Wolfrum, Christian Behl
Publikováno v: Redox Biology, Vol 24, Iss , Pp - (2019)
Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the most important hallmarks of aging and of neurodegenerative disorders. The proteasomal and autophagic-lysosomal degradation pathways are key measures to maintai
Externí odkaz: https://doaj.org/article/ed04d6a2923e4977a7ca0bd92a5b19d9
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4
Akademický článek
Neuroprotective and neuroregenerative effects of CRMP-5 on retinal ganglion cells in an experimental in vivo and in vitro model of glaucoma.
Autor: Jasmin Lauzi, Fabian Anders, Hanhan Liu, Norbert Pfeiffer, Franz Grus, Solon Thanos, Stefan Arnhold, Verena Prokosch
Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0207190 (2019)
PurposeTo analyze the potential neuro-protective and neuro-regenerative effects of Collapsin-response-mediator-protein-5 (CRMP-5) on retinal ganglion cells (RGCs) using in vitro and in vivo animal models of glaucoma.MethodsElevated intraocular pressu
Externí odkaz: https://doaj.org/article/f14dcd718ade44b583d91b448a68a975
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5
Akademický článek
Reduced mRNA and protein expression of the genomic caretaker RAD9A in primary fibroblasts of individuals with childhood and independent second cancer.
Autor: Eva Weis, Holger Schoen, Anja Victor, Claudia Spix, Marco Ludwig, Brigitte Schneider-Raetzke, Nicolai Kohlschmidt, Oliver Bartsch, Aslihan Gerhold-Ay, Nils Boehm, Franz Grus, Thomas Haaf, Danuta Galetzka
Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25750 (2011)
BACKGROUND: The etiology of secondary cancer in childhood cancer survivors is largely unclear. Exposure of normal somatic cells to radiation and/or chemotherapy can damage DNA and if not all DNA lesions are properly fixed, the mis-repair may lead to
Externí odkaz: https://doaj.org/article/bb7e61c65dcf416ca8b5d41825ff5c99
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6
CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus
Autor: Florian Hetsch, Danni Wang, Xufeng Chen, Jiong Zhang, Muhammad Aslam, Marcel Kegel, Henrik Tonner, Franz Grus, Jakob von Engelhardt
Publikováno v: The Journal of Physiology. 600:3549-3565
Relay neurons of the dorsal lateral geniculate nucleus (dLGN) receive inputs from retinal ganglion cells via retinogeniculate synapses. These connections undergo pruning in the first 2 weeks after eye opening. The remaining connections are strengthen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65d77029139fc4325a02604a416ba2f
https://doi.org/10.1113/jp283172
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10
Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma
Autor: Henrik Tonner, Selina Hunn, Nadine Auler, Carsten Schmelter, Norbert Pfeiffer, Franz Grus
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13618
Slow and progressive loss of retinal ganglion cells (RGCs) is the main characteristic of glaucoma, the second leading cause of blindness worldwide. Previous studies have shown that impaired mitochondrial dynamics could facilitate retinal neurodegener
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4308cc8fc1eb47055ada1a5fc08f6316
https://doi.org/10.3390/ijms232113618
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