Rafoxanide negatively modulates STAT3 and NF-κB activity and inflammation-associated colon tumorigenesis.

Autor: Pacifico T; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Stolfi C; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Tomassini L; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Luiz-Ferreira A; Inflammatory Bowel Disease Research Laboratory, Department of Biological Sciences, Institute of Biotechnology, Federal University of Catalão (UFCAT), Catalão, Brazil., Franzè E; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Ortenzi A; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Colantoni A; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Sica GS; Department of Surgery, University of Rome 'Tor Vergata', Rome, Italy., Sambucci M; Neuroimmunology Unit, Santa Lucia Foundation IRCCS, Rome, Italy., Monteleone I; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy., Monteleone G; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Laudisi F; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy.

Publikováno v: Cancer science [Cancer Sci] 2024 Nov; Vol. 115 (11), pp. 3596-3611. Date of Electronic Publication: 2024 Sep 06.

Targeting hepcidin in colorectal cancer triggers a TNF-dependent-gasdermin E-driven immunogenic cell death response.

Autor: Di Grazia A; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Franzè E; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Frascatani R; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Laudisi F; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Pacifico T; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Tomassini L; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Di Fusco D; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Formica V; Medical Oncology Unit, Fondazione Policlinico 'Tor Vergata', Rome, Italy., Sica G; Department of Surgery, University Rome of 'Tor Vergata', Rome, Italy., Stolfi C; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Monteleone I; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy., Monteleone G; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy. Gi.Monteleone@Med.uniroma2.it.; Gastroenterology Unit, Fondazione Policlinico 'Tor Vergata', Rome, Italy. Gi.Monteleone@Med.uniroma2.it.

Publikováno v: Experimental hematology & oncology [Exp Hematol Oncol] 2024 Sep 27; Vol. 13 (1), pp. 95. Date of Electronic Publication: 2024 Sep 27.

An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa

Autor: Di Fusco, D, Segreto, Mt, Iannucci, A, Maresca, C, Franzè, E, Di Maggio, G, Di Grazia, A, Boccanera, S, Laudisi, F, Marafini, I, Paoluzi, Oa, Michenzi, A, Monteleone, G, Monteleone, I

Publikováno v: Frontiers in Immunology. 14

Background and aimType I interferons (IFNs) are highly expressed in the gut mucosa of celiac disease (CD) gut mucosa and stimulates immune response prompted by gluten ingestion, but the processes that maintain the production of these inflammatory mol

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