Natural Product Graveoline Modulates Kirsten Rat Sarcoma Viral Oncogene Homologue (KRAS) Membrane Association: Insights from Advanced Spectroscopic Studies.

Autor: Cornilescu, Gabriel, Bindu, Lakshman, Sternicki, Louise, Chao, Fa-An, Gillette, William K., Fer, Nicole, Colombus, John, Castillo, Jean, Bonilla, Pedro Andrade, Van, Que N., Larsen, Erik, Hong, Min, Burgan, William, Turbyville, Thomas, Nissley, Dwight V., Liu, Miaomiao, Quinn, Ronald, Jean-Francois, Frantz L.

Publikováno v: ACS Pharmacology & Translational Science; 7/12/2024, Vol. 7 Issue 7, p1983-1995, 13p

Ancient mitogenomes from Pre-Pottery Neolithic Central Anatolia and the effects of a Late Neolithic bottleneck in sheep ( Ovis aries ).

Autor: Sandoval-Castellanos E; Population Genomics Group, Department of Veterinary Sciences, LMU Munich, 82152 Martinsried, Germany.; Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, LMU Munich, 80539 Munich, Germany., Hare AJ; Smurfit Institute of Genetics, Trinity College Dublin, Dublin D02 PN40, Ireland., Lin AT; The Palaeogenomics and Bio-archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK.; Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, 20560 USA., Dimopoulos EA; The Palaeogenomics and Bio-archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK.; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Daly KG; Smurfit Institute of Genetics, Trinity College Dublin, Dublin D02 PN40, Ireland.; School of Agriculture and Food Science, University College Dublin, Dublin, Ireland., Geiger S; Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, LMU Munich, 80539 Munich, Germany., Mullin VE; Smurfit Institute of Genetics, Trinity College Dublin, Dublin D02 PN40, Ireland., Wiechmann I; Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, LMU Munich, 80539 Munich, Germany., Mattiangeli V; Smurfit Institute of Genetics, Trinity College Dublin, Dublin D02 PN40, Ireland., Lühken G; Institute of Animal Breeding and Genetics, Justus Liebig University of Gießen, Ludwigstr. 21, 35390 Gießen, Germany., Zinovieva NA; L.K. Ernst Federal Research Centre for Animal Husbandry, Dubrovitsy, Podolsk, Moscow Region, Russia., Zidarov P; Institute of Prehistory, Early History and Medieval Archaeology, Tübingen University, Tübingen, Germany., Çakırlar C; Institute of Archaeology, University of Groningen, 9712 ER Groningen, Netherlands., Stoddart S; Magdalene College, University of Cambridge, Cambridge CB3 0AG, UK., Orton D; BioArCh, Department of Archaeology, University of York, York YO10 5NG, UK., Bulatović J; Department of Historical Studies, University of Gothenburg, BOX 200, 40530 Gothenburg, Sweden., Mashkour M; Unité Archéozoologie, Archéobotanique, Sociétés Pratiques et Environnements (AASPE), CNRS, Muséum National d'Histoire Naturelle, 75020 Paris, France., Sauer EW; School of History, Classics and Archaeology, University of Edinburgh, Old Medical School, Teviot Place, Edinburgh EH8 9AG, UK., Horwitz LK; National Natural History Collections, Faculty of Life Sciences, The Hebrew University, Jerusalem, Israel., Horejs B; OeAI, Austrian Academy of Sciences and HEAS, University of Vienna, Vienna, Austria., Atici L; Department of Anthropology, University of Nevada, Las Vegas, NV 89154, USA., Özkaya V; Department of Archaeology, Dicle University, Diyarbakir, Türkiye., Mullville J; School of History, Archaeology and Religion, Cardiff University, Cardiff CF10 3EU, UK., Parker Pearson M; Institute of Archaeology, University College London, London, UK., Mainland I; The University of the Highlands and Islands Orkney, Kirkwall, UK., Card N; The University of the Highlands and Islands Orkney, Kirkwall, UK., Brown L; Wiltshire Museum, Devizes SN10 1NS, UK., Sharples N; School of History, Archaeology and Religion, Cardiff University, Cardiff CF10 3EU, UK., Griffiths D; University of Oxford, OUDCE, Rewley House, Oxford OX1 2JA, UK., Allen D; Hampshire Cultural Trust, Chilcomb House, Winchester, SO23 8RB, UK., Arbuckle B; Department of Anthropology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Abell JT; Department of Geosciences, University of Arizona, Tucson, AZ 85721, USA., Duru G; Department of Archaeology, Mimar Sinan Fine Arts University, 34381 Şişli/İstanbul, Türkiye., Mentzer SM; Senckenberg Centre for Human Evolution and Palaeoenvironment, Institute for Archaeological Sciences, Department of Geosciences, Tübingen University, 72074 Tübingen, Germany., Munro ND; Department of Anthropology, University of Connecticut, Storrs, CT 06269, USA., Uzdurum M; Department of Archaeology, Ondokuz Mayıs University, 55270 Atakum/Samsun, Türkiye., Gülçur S; Prehistory Department, Faculty of Letters, Istanbul University, 34134 Istanbul, Türkiye., Buitenhuis H; Archeosupport, 9712 LN Groningen, Netherlands., Gladyr E; L.K. Ernst Federal Research Centre for Animal Husbandry, Dubrovitsy, Podolsk, Moscow Region, Russia., Stiner MC; School of Anthropology, University of Arizona, Tucson, AZ 85721, USA., Pöllath N; Bavarian Natural History Collections, State Collection of Palaeoanatomy Munich, 80333 Munich, Germany.; ArchaeoBioCenter, LMU Munich, 80539 Munich, Germany., Özbaşaran M; Prehistory Department, Faculty of Letters, Istanbul University, 34134 Istanbul, Türkiye., Krebs S; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Feodor-Lynen-Straße 25, 81377 Munich, Germany., Burger J; Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, 55128 Mainz, Germany., Frantz L; Palaeogenomics Group, Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, LMU Munich, 80539 Munich, Germany.; School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK., Medugorac I; Population Genomics Group, Department of Veterinary Sciences, LMU Munich, 82152 Martinsried, Germany.; ArchaeoBioCenter, LMU Munich, 80539 Munich, Germany., Bradley DG; Smurfit Institute of Genetics, Trinity College Dublin, Dublin D02 PN40, Ireland., Peters J; Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, LMU Munich, 80539 Munich, Germany.; Bavarian Natural History Collections, State Collection of Palaeoanatomy Munich, 80333 Munich, Germany.; ArchaeoBioCenter, LMU Munich, 80539 Munich, Germany.

Publikováno v: Science advances [Sci Adv] 2024 Apr 12; Vol. 10 (15), pp. eadj0954. Date of Electronic Publication: 2024 Apr 12.

Boulevards of black ink.

Autor: SOULE, ALEXANDER casoule@westfairinc.com

Publikováno v: Fairfield County Business Journal. 4/19/2010, Vol. 49 Issue 16, p12-14. 2p.

A compendium of genetic regulatory effects across pig tissues.

Autor: Teng J; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Gao Y; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China.; Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service (ARS), U.S. Department of Agriculture (USDA), Beltsville, MD, USA.; Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA., Yin H; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China., Bai Z; Center for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark.; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Liu S; Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service (ARS), U.S. Department of Agriculture (USDA), Beltsville, MD, USA.; School of Life Sciences, Westlake University, Hangzhou, China., Zeng H; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Bai L; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China., Cai Z; Center for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark., Zhao B; College of Animal Science and Technology, China Agricultural University, Beijing, China., Li X; Guangdong Provincial Key Laboratory of Waterfowl Healthy Breeding, College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China., Xu Z; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Lin Q; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Pan Z; Department of Animal Science, University of California, Davis, Davis, CA, USA.; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China., Yang W; College of Animal Science and Technology, China Agricultural University, Beijing, China.; Department of Animal Science, University of California, Davis, Davis, CA, USA., Yu X; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Guan D; Department of Animal Science, University of California, Davis, Davis, CA, USA., Hou Y; Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China., Keel BN; ARS, USDA, U.S. Meat Animal Research Center, Clay Center, NE, USA., Rohrer GA; ARS, USDA, U.S. Meat Animal Research Center, Clay Center, NE, USA., Lindholm-Perry AK; ARS, USDA, U.S. Meat Animal Research Center, Clay Center, NE, USA., Oliver WT; ARS, USDA, U.S. Meat Animal Research Center, Clay Center, NE, USA., Ballester M; Animal Breeding and Genetics Programme, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Torre Marimon, Caldes de Montbui, Spain., Crespo-Piazuelo D; Animal Breeding and Genetics Programme, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Torre Marimon, Caldes de Montbui, Spain., Quintanilla R; Animal Breeding and Genetics Programme, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Torre Marimon, Caldes de Montbui, Spain., Canela-Xandri O; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Rawlik K; Baillie Gifford Pandemic Science Hub, University of Edinburgh, Edinburgh, UK., Xia C; Lothian Birth Cohort studies, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Yao Y; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; School of Informatics, The University of Edinburgh, Edinburgh, UK., Zhao Q; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China., Yao W; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.; Animal Breeding and Genomics, Wageningen University and Research, Wageningen, The Netherlands., Yang L; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China., Li H; Center for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark., Zhang H; Center for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark., Liao W; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Chen T; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Karlskov-Mortensen P; Animal Genetics, Bioinformatics and Breeding, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark., Fredholm M; Animal Genetics, Bioinformatics and Breeding, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark., Amills M; Department of Animal Genetics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus de la Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra, Spain., Clop A; Department of Animal Genetics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus de la Universitat Autònoma de Barcelona, Bellaterra, Spain.; Consejo Superior de Investigaciones Científicas, Barcelona, Spain., Giuffra E; Paris-Saclay University, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France., Wu J; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Cai X; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Diao S; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Pan X; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Wei C; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Li J; Department of Animal Science, University of California, Davis, Davis, CA, USA., Cheng H; Department of Animal Science, University of California, Davis, Davis, CA, USA., Wang S; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Su G; Center for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark., Sahana G; Center for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark., Lund MS; Center for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark., Dekkers JCM; Department of Animal Science, Iowa State University, Ames, IA, USA., Kramer L; Department of Animal Science, Iowa State University, Ames, IA, USA., Tuggle CK; Department of Animal Science, Iowa State University, Ames, IA, USA., Corbett R; Department of Animal Science, Iowa State University, Ames, IA, USA., Groenen MAM; Animal Breeding and Genomics, Wageningen University and Research, Wageningen, The Netherlands., Madsen O; Animal Breeding and Genomics, Wageningen University and Research, Wageningen, The Netherlands., Gòdia M; Animal Breeding and Genomics, Wageningen University and Research, Wageningen, The Netherlands.; Department of Animal Genetics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus de la Universitat Autònoma de Barcelona, Bellaterra, Spain., Rocha D; Paris-Saclay University, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France., Charles M; Paris-Saclay University, INRAE, AgroParisTech, GABI, SIGENAE, Jouy-en-Josas, France., Li CJ; Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service (ARS), U.S. Department of Agriculture (USDA), Beltsville, MD, USA., Pausch H; Animal Genomics, ETH Zurich, Universitaetstrasse 2, Zurich, Switzerland., Hu X; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China., Frantz L; Palaeogenomics Group, Department of Veterinary Sciences, Ludwig Maximilian University, Munich, Germany.; School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK., Luo Y; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.; Lars Bolund Institute of Regenerative Medicine, Qingdao-Europe Advanced Institute for Life Sciences, BGI-Research, Qingdao, China., Lin L; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., Zhou Z; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Zhang Z; Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou, China., Chen Z; Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou, China., Cui L; School of Life Sciences, Nanchang University, Nanchang, China.; Human Aging Research Institute and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Jiangxi, China.; UCL Genetics Institute, University College London, London, UK., Xiang R; Faculty of Veterinary and Agricultural Science, The University of Melbourne, Parkville, Victoria, Australia.; Agriculture Victoria, AgriBio, Centre for AgriBiosciences, Bundoora, Victoria, Australia., Shen X; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.; Center for Intelligent Medicine Research, Greater Bay Area Institute of Precision Medicine, Fudan University, Guangzhou, China.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Li P; Institute of Swine Science, Nanjing Agricultural University, Nanjing, China., Huang R; Institute of Swine Science, Nanjing Agricultural University, Nanjing, China., Tang G; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China., Li M; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China., Zhao Y; College of Animal Science and Technology, Guangxi University, Nanning, China., Yi G; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China., Tang Z; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China., Jiang J; Department of Animal Science, North Carolina State University, Raleigh, NC, USA., Zhao F; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China., Yuan X; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Liu X; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China., Chen Y; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China., Xu X; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education and College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China., Zhao S; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education and College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China., Zhao P; Hainan Institute, Zhejiang University, Yongyou Industry Park, Yazhou Bay Sci-Tech City, Sanya, China., Haley C; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; The Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian, UK., Zhou H; Department of Animal Science, University of California, Davis, Davis, CA, USA., Wang Q; Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou, China., Pan Y; Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou, China., Ding X; College of Animal Science and Technology, China Agricultural University, Beijing, China., Ma L; Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA., Li J; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China., Navarro P; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; The Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian, UK., Zhang Q; College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China., Li B; Scotland's Rural College (SRUC), Roslin Institute Building, Midlothian, UK., Tenesa A; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK. albert.tenesa@ed.ac.uk.; The Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian, UK. albert.tenesa@ed.ac.uk., Li K; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China. likui@caas.cn., Liu GE; Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service (ARS), U.S. Department of Agriculture (USDA), Beltsville, MD, USA. george.liu@usda.gov., Zhang Z; State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University (SCAU), Guangzhou, China. zhezhang@scau.edu.cn., Fang L; Center for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark. lingzhao.fang@qgg.au.dk.; MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK. lingzhao.fang@qgg.au.dk.

Publikováno v: Nature genetics [Nat Genet] 2024 Jan; Vol. 56 (1), pp. 112-123. Date of Electronic Publication: 2024 Jan 04.

Membrane-bound KRAS approximates an entropic ensemble of configurations

Autor: Frantz L. Jean-Francois, Andrew G. Stephen, Frank Heinrich, Mathias Lösche, Que N. Van

Publikováno v: Biophys J

KRAS4B is a membrane-anchored signaling protein and a primary target in cancer research. Predictions from molecular dynamics simulations that have previously shaped our mechanistic understanding of KRAS signaling disagree with recent experimental res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014aae448032c0637f5bb87624cabccf
https://doi.org/10.1016/j.bpj.2021.08.008