Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Frantisek Hubalek"'
Autor:
Thomas Kjeldsen, Wouter F. J. Hogendorf, Christian W. Tornøe, Jonathan Anderson, Frantisek Hubalek, Carsten E. Stidsen, Jan L. Sorensen, Thomas Hoeg-Jensen
Publikováno v:
ACS Omega, Vol 5, Iss 31, Pp 19827-19833 (2020)
Externí odkaz:
https://doaj.org/article/fbe8339db2cc4c5188d391217970d406
Autor:
Andreas Vegge, Jacob Wainer, Joy Collins, Ellen Marie Straarup, Ley Mikkel Wennemoes Hvitfeld, Siddartha Tamang, Herskind Peter, Stephen T. Buckley, Rikke Kaae Kirk, Ulrik Lytt Rahbek, Keiko Ishida, Xiaoya Lu, Brian Mouridsen, Jespersen Mikkel Oliver, Mette Poulsen, Stefán B Gunnarsson, Frantisek Hubalek, Johannes Josef Fels, Jorrit Jeroen Water, Alison Hayward, Adam Bohr, Robert Langer, Giovanni Traverso, Abramson Alex G, Morten Revsgaard Frederiksen, Brian Jensen, Jesper Peter Windum, Niclas Roxhed
Publikováno v:
Nat Biotechnol
Oral administration provides a simple and non-invasive approach for drug delivery. However, due to poor absorption and swift enzymatic degradation in the gastrointestinal tract, a wide range of molecules must be parenterally injected to attain requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3bd9e6eb963ac954ee4719462cdd4e
https://doi.org/10.1038/s41587-021-01024-0
https://doi.org/10.1038/s41587-021-01024-0
Autor:
František Hubálek, Christian N. Cramer, Hans Helleberg, Eva Johansson, Erica Nishimura, Gerd Schluckebier, Dorte Bjerre Steensgaard, Jeppe Sturis, Thomas B. Kjeldsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Insulin icodec is a once-weekly insulin analogue that has a long half-life of approximately 7 days, making it suitable for once weekly dosing. The Insulin icodec molecule was developed based on the hypothesis that lowering insulin receptor a
Externí odkaz:
https://doaj.org/article/ade547bc0d3d4366b9971dbb3db3a7f1
Autor:
Ulrike Hövelmann, Erica Nishimura, Thomas Kjeldsen, Frantisek Hubalek, Tine Glendorf, Carsten E. Stidsen, Bo F. Hansen, Thomas A. Pedersen, Anne Lützen, Lone Pridal, Peter Madsen
Publikováno v:
Hand in Hand zum Ziel – einfach.besser.messbar www.diabeteskongress.de.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df180a7a304f2f39d265b4c60a4d173b
https://doi.org/10.1055/s-0042-1746280
https://doi.org/10.1055/s-0042-1746280
Autor:
Carsten Enggaard Stidsen, Jan Lindy Sorensen, Jonathan Anderson, Thomas Kjeldsen, Thomas Hoeg-Jensen, Christian Wenzel Tornøe, Frantisek Hubalek, Wouter F. J. Hogendorf
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 31, Pp 19827-19833 (2020)
ACS Omega, Vol 5, Iss 31, Pp 19827-19833 (2020)
Covalent cross-linking of biomolecules can be useful in pursuit of tissue targeting or dual targeting of two receptors on cell surfaces for avidity effects. Long linkers (>10 kDa) can be advantageous for such purposes, and poly(ethylene glycol) (PE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058e5f59cc1b84c349d7aa3a7c03f8e6
https://doi.org/10.1021/acsomega.0c02712
https://doi.org/10.1021/acsomega.0c02712
Autor:
Erik M. Wulff, Patrick William Garibay, Eva Johansson, Martin Münzel, Tine Glendorf, Erica Nishimura, Bo Falck Hansen, Thomas Kjeldsen, Peter Madsen, Christian L. Brand, Sanne Gram-Nielsen, Trine Porsgaard, Hanne H. F. Refsgaard, Frantisek Hubalek, Svend Ludvigsen, Dorte Bjerre Steensgaard, Lars Hovgaard, Carsten Enggaard Stidsen, Susanne Rugh, Jonas Kildegaard, Lone Pridal, Maja Jensen, Christian Hove Claussen, Ulla Ribel, Alan D. Cherrington, Mary Courtney Moore, Peter Kresten Nielsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Recently, the clinical proof of concept for the first ultra-long oral insulin was reported, showing efficacy and safety similar to subcutaneously administered insulin glargine. Here, we report the molecular engineering as well as biological and pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113155943c2b6a189cde64bb824cd5b9
https://doaj.org/article/b3637544155945e480839f9c67516402
https://doaj.org/article/b3637544155945e480839f9c67516402
Autor:
Peter Madsen, Thomas Kjeldsen, Claus Bekker Jeppesen, Hanne H. F. Refsgaard, Trine Porsgaard, Helle Naver, Sanne Gram-Nielsen, Frantisek Hubalek, Lone Pridal, Tina Møller Tagmose, Erica Nishimura, Inger Lautrup-Larsen, Carsten Enggaard Stidsen, Valentina Manfè, Thomas Hoeg-Jensen, Claudia Ulrich Hjørringgaard, Svend Ludvigsen, Christian Fledelius
Publikováno v:
Journal of medicinal chemistry. 64(13)
Here, we describe the molecular engineering of insulin icodec to achieve a plasma half-life of 196 h in humans, suitable for once-weekly subcutaneously administration. Insulin icodec is based on re-engineering of the ultra-long oral basal insulin OI3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bbecdf553cdca0c9ff44818b4017bb
https://pubmed.ncbi.nlm.nih.gov/33944562
https://pubmed.ncbi.nlm.nih.gov/33944562
Autor:
Hanne Haahr, Carsten Enggaard Stidsen, Rasmus Ribel-Madsen, Anne Lützen, Thomas Åskov Pedersen, Karsten Lyby, Lone Pridal, Thomas Kjeldsen, Peter Madsen, Frantisek Hubalek, Bo Falk Hansen, Erica Nishimura, Niels Rode Kristensen, Tine Glendorf
Publikováno v:
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
IntroductionInsulin icodec is a novel, long-acting insulin analog designed to cover basal insulin requirements with once-weekly subcutaneous administration. Here we describe the molecular engineering and the biological and pharmacological properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759dbb38cb97c67986c9ef3b1c415879
https://pubmed.ncbi.nlm.nih.gov/34413118
https://pubmed.ncbi.nlm.nih.gov/34413118
Autor:
Joy Collins, Andreas Vegge, Frantisek Hubalek, Shane McDonnell, Tadayuki Yoshitake, Fauziah R. Zakaria, Jacob Wainer, Ryan Yu Tian, Ulrik Lytt Rahbek, Soyoung Kim, Robert Langer, Giovanni Traverso, Alison Hayward, Raissa Yona, Xiaoya Lu, Ester Caffarel-Salvador, Vance Soares, Morten Revsgaard Frederiksen, Daniel Minahan, Keiko Ishida, Jessica Wong, Rebecca McManus, Xiewen Liu, Siddartha Tamang, James G. Fujimoto, Johannes Josef Fels, Sarah R. Stern, Niclas Roxhed
Publikováno v:
Science advances. 7(4)
Alternative means for drug delivery are needed to facilitate drug adherence and administration. Microneedles (MNs) have been previously investigated transdermally for drug delivery. To date, drug loading into MNs has been limited by drug solubility i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f62ba4a36beb90335f0502f013c93f
https://pubmed.ncbi.nlm.nih.gov/33523951
https://pubmed.ncbi.nlm.nih.gov/33523951
Autor:
Ulla Ribel, Erik M. Wulff, Alan D. Cherrington, Peter Kresten Nielsen, Martin Münzel, Thomas Kjeldsen, Svend Ludvigsen, Frantisek Hubalek, Lars Hovgaard, Christian Hove Claussen, Jonas Kildegaard, Maja Jensen, Lone Pridal, Hanne H. F. Refsgaard, Patrick William Garibay, Mary Courtney Moore, Sanne Gram-Nielsen, Erica Nishimura, Dorte Bjerre Steensgaard, Carsten Enggaard Stidsen, Tine Glendorf, Peter Madsen, Susanne Rugh, Bo Falck Hansen, Eva Johansson, Christian L. Brand, Trine Porsgaard
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6582242c3083f360c87f02dd8695f95
http://europepmc.org/articles/PMC7441397
http://europepmc.org/articles/PMC7441397