LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules

Autor: Frantiescoli A. Dimer, Maiara C. Pigatto, Adriana R. Pohlmann, Teresa Dalla Costa, Silvia S. Guterres

Publikováno v: Química Nova, Vol 37, Iss 8, Pp 1371-1376 (2014)

In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using small plasma volume (0.1 mL)

Externí odkaz: https://doaj.org/article/c0476a59ae5742fd947a82202bb95e1b

PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus

Autor: Claus-Michael Lehr, Adriely Goes, Jennifer Herrmann, Frantiescoli Anversa Dimer, Cristiane de Souza Carvalho-Wodarz, Markus Bischoff, Viktoria Schmitt, Patrick Couvreur, Chiara De Rossi, Linda Pätzold, Katarina Cirnski, Nadia Abed, Rolf Müller

Publikováno v: Nanomedicine : nanotechnology, biology, and medicine

Drug delivery systems are promising for targeting antibiotics directly to infected tissues. To reach intracellular Staphylococcus aureus and Mycobacterium abscessus, we encapsulated clarithromycin in PLGA nanocapsules, suitable for aerosol delivery b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11eca62af633bbb5565c9e661c1873f7
https://hdl.handle.net/10033/622059

Mucoadhesive Amphiphilic Methacrylic Copolymer-Functionalized Poly(ε-caprolactone) Nanocapsules for Nose-to-Brain Delivery of Olanzapine

Autor: Francisco N. Fonseca, Maria Palmira Daflon Gremião, Silvia Stanisçuaski Guterres, Flávia Chiva Carvalho, Frantiescoli Anversa Dimer, Andresa Heemann Betti, Adriana Raffin Pohlmann, Marli Luiza Tebaldi, Stela Maris Kuze Rates

Publikováno v: Journal of Biomedical Nanotechnology. 11:1472-1481

Nose-to-brain drug delivery has been proposed to overcome the low absorption of drugs in central nervous system due to the absence of brain-blood barrier in the olfactory nerve pathway. However, the presence of a mucus layer and quick clearance limit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::072be7efc2907cf994cdc645babce4b2
https://doi.org/10.1166/jbn.2015.2078

Impactos da nanotecnologia na saúde: produção de medicamentos

Autor: Ruy Carlos Ruver Beck, Frantiescoli Anversa Dimer, Rossana B. Friedrich, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann

Publikováno v: Química Nova, Vol 36, Iss 10, Pp 1520-1526 (2013)
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Química Nova v.36 n.10 2013
Química Nova
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Química Nova, Volume: 36, Issue: 10, Pages: 1520-1526, Published: 2013

Several studies have described the benefits of nanoscience and nanotechnology (N&N) in different sectors such as agriculture, energy, environmental preservation, and public health. The rapid evolution of N&N can be shown through a panoramic analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5e026501edbffac8caf1c7a0a03188
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013001000007&lng=en&tlng=en

Nanoencapsulation Improves Relative Bioavailability and Antipsychotic Effect of Olanzapine in Rats

Autor: Rates Mk, S.S. Guterres, Frantiescoli Anversa Dimer, Marilise Escobar Burger, Maiara Cássia Pigatto, Dalla Costa T, Camila Simonetti Pase, Boque Ca, Katiane Roversi, Adriana Raffin Pohlmann

Publikováno v: Journal of biomedical nanotechnology. 11(8)

This study aimed to investigate the pharmacokinetics, tissue distribution and antipsychotic activity of olanzapine administered as free drug (OLA-FREE) or loaded into lipid-core nanocapsules (OLA-LNC). OLA-LNC were successfully developed with a parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf37502c7b6c44e4ea2338dc2ac62cd
https://pubmed.ncbi.nlm.nih.gov/26295148