Zobrazeno 1 - 10
of 17
pro vyhledávání: '"František Bárta"'
Autor:
František Bárta, Alena Dedíková, Michaela Bebová, Šárka Dušková, Jaroslav Mráz, Heinz H. Schmeiser, Volker M. Arlt, Petr Hodek, Marie Stiborová
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10479 (2021)
The plant extract aristolochic acid (AA), containing aristolochic acids I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases associated with upper urothelial
Externí odkaz:
https://doaj.org/article/67a119f84dac49abadf36061f010ca65
Autor:
Marie Stiborová, František Bárta, Kateřina Levová, Petr Hodek, Heinz H. Schmeiser, Volker M. Arlt, Václav Martínek
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27561-27575 (2015)
Aristolochic acid I (AAI) is a plant alkaloid causing aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is detoxified by cytochrome P450 (CYP)-mediated O-demethylation to 8-hydroxyaristolochic
Externí odkaz:
https://doaj.org/article/deb96ba69f364149b998d2bdee98daab
Autor:
Jan Milichovký, František Bárta, Heinz H. Schmeiser, Volker M. Arlt, Eva Frei, Marie Stiborová, Václav Martínek
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 2, p 213 (2016)
Aristolochic acid I (AAI) is a plant drug found in Aristolochia species that causes aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is activated via nitroreduction producing genotoxic N-hydr
Externí odkaz:
https://doaj.org/article/b3c31dce12f148b8a6b685a352a73799
Autor:
Václav Martínek, František Bárta, Volker M. Arlt, Petr Hodek, Kevin Kotalík, Marie Stiborová, Alena Dedı́ková, Šárka Dušková, Jaroslav Mráz
Publikováno v:
Chemical Research in Toxicology. 33:2804-2818
The plant extract aristolochic acid (AA), containing aristolochic acid I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy and Balkan endemic nephropathy, unique renal d...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4fcfd17751f58285c1aa40c80804a8f
https://doi.org/10.1021/acs.chemrestox.0c00198
https://doi.org/10.1021/acs.chemrestox.0c00198
Autor:
Marie Stiborová, Volker M. Arlt, Petr Hodek, Heinz H. Schmeiser, Michaela Bebová, Šárka Dušková, Jaroslav Mráz, František Bárta, Alena Dedı́ková
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10479, p 10479 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences
Volume 22
Issue 19
The plant extract aristolochic acid (AA), containing aristolochic acids I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases associated with upper urothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ec0a900fcfe566adb966dedacd7522
https://www.mdpi.com/1422-0067/22/19/10479
https://www.mdpi.com/1422-0067/22/19/10479
Autor:
Radek Indra, David H. Phillips, Volker M. Arlt, Iveta Mrizova, Colin J. Henderson, Michaela Moserová, Klaus Kopka, Lindsay Reed, Heinz H. Schmeiser, František Bárta, Marie Stiborová, C. Roland Wolf
Publikováno v:
Archives of Toxicology
Reed, L, Mrizova, I, Barta, F, Indra, R, Moserova, M, Kopka, K, Schmeiser, H H, Wolf, C R, Henderson, C J, Stiborova, M, Phillips, D H & Arlt, V M 2018, ' Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation : studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice ', Archives of Toxicology, vol. 92, no. 4, pp. 1625-1638 . https://doi.org/10.1007/s00204-018-2162-7
Reed, L, Mrizova, I, Barta, F, Indra, R, Moserova, M, Kopka, K, Schmeiser, H H, Wolf, C R, Henderson, C J, Stiborova, M, Phillips, D H & Arlt, V M 2018, ' Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation : studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice ', Archives of Toxicology, vol. 92, no. 4, pp. 1625-1638 . https://doi.org/10.1007/s00204-018-2162-7
Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s. In the present study, Hepatic Reductase Null (HRN) and Hepatic Cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a216efdfc1a564d9b4cf13894220ebe0
http://europepmc.org/articles/PMC5882632
http://europepmc.org/articles/PMC5882632
Autor:
Annette M. Krais, Eszter Nagy, Volker M. Arlt, David H. Phillips, Walter Meinl, Iveta Mrizova, Simone Florian, Amin Mirza, František Bárta, Maggie Liu, Hansruedi Glatt, Marlies Thomann, Heinz H. Schmeiser, Klaus Kopka, Meirion Richards, Marie Stiborová
Publikováno v:
Arlt, V M, Meinl, W, Florian, S, Nagy, E, Barta, F, Thomann, M, Mrizova, I, Krais, A M, Liu, M, Richards, M, Mirza, A, Kopka, K, Phillips, D H, Glatt, H, Stiborova, M & Schmeiser, H H 2017, ' Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone ', Archives of Toxicology, vol. 91, no. 4, pp. 1957-1975 . https://doi.org/10.1007/s00204-016-1808-6
Archives of Toxicology
Archives of Toxicology
Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fdc183e5db200f968b9012fc2e83a4
https://doi.org/10.1007/s00204-016-1808-6
https://doi.org/10.1007/s00204-016-1808-6
Autor:
Volker M. Arlt, Heinz H. Schmeiser, Kateřina Levová, Marie Stiborová, František Bárta, Petr Hodek, Václav Martínek
Publikováno v:
International Journal of Molecular Sciences; Volume 16; Issue 11; Pages: 27561-27575
Stiborová, M, Bárta, F, Levová, K, Hodek, P, Schmeiser, H H, Arlt, V M & Martínek, V 2015, ' A mechanism of O-demethylation of aristolochic acid I by cytochromes P450 and their contributions to this reaction in human and rat livers : Experimental and theoretical approaches ', International Journal of Molecular Sciences, vol. 16, no. 11, pp. 27561-27575 . https://doi.org/10.3390/ijms161126047
International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27561-27575 (2015)
International Journal of Molecular Sciences
Stiborová, M, Bárta, F, Levová, K, Hodek, P, Schmeiser, H H, Arlt, V M & Martínek, V 2015, ' A mechanism of O-demethylation of aristolochic acid I by cytochromes P450 and their contributions to this reaction in human and rat livers : Experimental and theoretical approaches ', International Journal of Molecular Sciences, vol. 16, no. 11, pp. 27561-27575 . https://doi.org/10.3390/ijms161126047
International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27561-27575 (2015)
International Journal of Molecular Sciences
Aristolochic acid I (AAI) is a plant alkaloid causing aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is detoxified by cytochrome P450 (CYP)-mediated O-demethylation to 8-hydroxyaristolochic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a533317c104ec1d2c59504d0d51095ef
https://doi.org/10.3390/ijms161126047
https://doi.org/10.3390/ijms161126047
Autor:
Marie Stiborová, Volker M. Arlt, Kateřina Levová, Heinz H. Schmeiser, Miroslav Sulc, František Bárta, Eva Frei
Publikováno v:
Stiborová, M, Levová, K, Bárta, F, Sulc, M, Frei, E, Arlt, V M & Schmeiser, H H 2014, ' The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats ', Mutagenesis, vol. 29, no. 3, pp. 189-200 . https://doi.org/10.1093/mutage/geu004
UNLABELLED Aristolochic acid I (AAI) is the major toxic component of the plant extract AA, which leads to the development of nephropathy and urothelial cancer in human. Individual susceptibility to AAI-induced disease might reflect variability in enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190680c65fe06871e8306a8259ebd0cf
https://doi.org/10.1093/mutage/geu004
https://doi.org/10.1093/mutage/geu004
Autor:
Martínek, Jan Milichovský, František Bárta, Heinz Schmeiser, Volker Arlt, Eva Frei, Marie Stiborová, Václav
Publikováno v:
International Journal of Molecular Sciences; Volume 17; Issue 2; Pages: 213
Aristolochic acid I (AAI) is a plant drug found in Aristolochia species that causes aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is activated via nitroreduction producing genotoxic N-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::1d83e9a5e5a1f04a31cf03a9f5185f49