Targeted therapies in hepatocellular carcinoma: past, present, and future.

Autor: Gujarathi R; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, United States., Franses JW; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, United States., Pillai A; Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, University of Chicago, Chicago, IL, United States., Liao CY; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, United States.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 Aug 29; Vol. 14, pp. 1432423. Date of Electronic Publication: 2024 Aug 29 (Print Publication: 2024).

Scirrhous HCC: Another 'omic thread in the HCC tapestry.

Autor: Franses JW; Department of Medicine, Section of Hematology-Oncology, The University of Chicago Comprehensive Cancer Center, Chicago, Illinois, USA., Duda DG; Department of Radiation Oncology, Steele Laboratories for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2024 Apr 01; Vol. 79 (4), pp. 747-748. Date of Electronic Publication: 2023 Sep 19.

Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker.

Autor: Taylor MS; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts., Wu C; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts., Fridy PC; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York., Zhang SJ; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts., Senussi Y; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts., Wolters JC; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Cajuso T; Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Cheng WC; Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Heaps JD; Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Miller BD; Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Mori K; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.; Healthcare Optics Research Laboratory, Canon U.S.A., Inc., Cambridge, Massachusetts., Cohen L; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts., Jiang H; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York., Molloy KR; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York., Chait BT; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York., Goggins MG; Johns Hopkins University School of Medicine, Baltimore, Maryland., Bhan I; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Franses JW; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Yang X; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Taplin ME; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Wang X; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Christiani DC; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Johnson BE; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Meyerson M; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Uppaluri R; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Egloff AM; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Denault EN; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Spring LM; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Wang TL; Johns Hopkins University School of Medicine, Baltimore, Maryland., Shih IM; Johns Hopkins University School of Medicine, Baltimore, Maryland., Fairman JE; Johns Hopkins University School of Medicine, Baltimore, Maryland., Jung E; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Arora KS; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts., Yilmaz OH; Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts., Cohen S; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Sharova T; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Chi G; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Norden BL; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Song Y; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Nieman LT; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Pappas L; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Parikh AR; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Strickland MR; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Corcoran RB; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Mustelin T; Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington., Eng G; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.; The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts., Yilmaz ÖH; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.; The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts., Matulonis UA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Chan AT; Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Skates SJ; MGH Biostatistics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Rueda BR; Department of Obstetrics and Gynecology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts., Drapkin R; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Klempner SJ; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Deshpande V; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts., Ting DT; Mass General Cancer Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Rout MP; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York., LaCava J; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York.; European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, the Netherlands., Walt DR; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts., Burns KH; Department of Pathology, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

Publikováno v: Cancer discovery [Cancer Discov] 2023 Dec 12; Vol. 13 (12), pp. 2532-2547.

Patient-Reported Outcomes, Tumor Markers, and Survival Outcomes in Advanced GI Cancer.

Autor: Jarnagin JX; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Saraf A; Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston., Baiev I; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Chi G; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., van Seventer EE; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Mojtahed A; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston., Allen JN; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Clark JW; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Blaszkowsky L; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Giantonio BJ; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Weekes CD; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Klempner SJ; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Franses JW; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Roeland EJ; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Goyal L; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Siravegna G; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Horick N; Department of Statistics, Massachusetts General Hospital and Harvard Medical School, Boston., Corcoran RB; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston., Nipp RD; OU Health Stephenson Cancer Center, Section of Hematology and Oncology, Department of Internal Medicine, The University of Oklahoma (OU) College of Medicine, Oklahoma City., Parikh AR; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston.

Publikováno v: JAMA network open [JAMA Netw Open] 2023 Nov 01; Vol. 6 (11), pp. e2343512. Date of Electronic Publication: 2023 Nov 01.

Resection of NAFLD/NASH-related Hepatocellular Carcinoma (HCC): Clinical Features and Outcomes Compared with HCC Due to Other Etiologies.

Autor: Pal Chaudhary S; Division of Oncology, Mass General Cancer Center and Harvard Medical School, Boston, MA, USA., Reyes S; Duke University School of Medicine, Durham, NC, USA., Chase ML; Beth Israel Deaconess Hospital, Needham, MA, USA., Govindan A; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhao L; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Luther J; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Bhan I; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Bethea E; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Franses JW; Division of Oncology, Mass General Cancer Center and Harvard Medical School, Boston, MA, USA., Paige Walsh E; Division of Oncology, Mass General Cancer Center and Harvard Medical School, Boston, MA, USA., Anne Dageford L; Transplantation Unit, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kimura S; Transplantation Unit, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Elias N; Transplantation Unit, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Yeh H; Transplantation Unit, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Markman J; Transplantation Unit, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Bozorgzadeh A; Transplantation Unit, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Tanabe K; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ferrone C; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Zhu AX; Jiahui Health, Jiahui International Cancer Center, Shanghai, People's Republic of China., Andersson K; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Thiim M; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Antonio Catalano O; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kambadakone A; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Vagefi PA; Division of Surgical Transplantation, University of Texas Southwestern, Dallas, TX, USA., Qadan M; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Pratt D; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Hashemi N; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Corey KE; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Misdraji J; Department of Pathology, Yale New Haven Hospital, Yale University, New Haven, CT, USA., Goyal L; Division of Oncology, Mass General Cancer Center and Harvard Medical School, Boston, MA, USA., Clark JW; Division of Oncology, Mass General Cancer Center and Harvard Medical School, Boston, MA, USA.

Publikováno v: The oncologist [Oncologist] 2023 Apr 06; Vol. 28 (4), pp. 341-350.