Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Frans W. H. M. Merkus"'
Publikováno v:
Pharmaceutical Research, 21(5), 799-802. Springer New York
Van Den Berg, M P, Merkus, P, Romeijn, S G, Verhoef, J C & Merkus, F W H M 2004, ' Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery : Studies in rats and comparison with a human study ', Pharmaceutical Research, vol. 21, no. 5, pp. 799-802 . https://doi.org/10.1023/B:PHAM.0000026431.55383.69
Van Den Berg, M P, Merkus, P, Romeijn, S G, Verhoef, J C & Merkus, F W H M 2004, ' Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery : Studies in rats and comparison with a human study ', Pharmaceutical Research, vol. 21, no. 5, pp. 799-802 . https://doi.org/10.1023/B:PHAM.0000026431.55383.69
Purpose. To investigate the possibility of direct transport of melatonin from the nasal cavity into the cerebrospinal fluid (CSF) after nasal administration in rats and to compare the animal results with a human study. Methods. Rats (n = 8) were give
Publikováno v:
Journal of Neuroscience Methods. 116:99-107
Drug transport from the nasal cavity to the brain has gained much interest in the last decade. In the present study, a model was developed to determine the uptake of drugs into the cerebrospinal fluid (CSF) after nasal delivery in rats. CSF samples w
Autor:
Frans W. H. M. Merkus, J. W. M. Ter Berg, P-H. M. van der Kuy, P. M. Hooymans, J. J. H. M. Lohman
Publikováno v:
European Journal of Clinical Pharmacology. 55:677-680
A comparison of the pharmacokinetic properties of two novel intranasal preparations of dihydroergotamine mesilate (DHEM) with a commercially available intranasal preparation.Two intranasal formulations of DHEM in combination with randomly methylated
Autor:
Maya Thanou, Frans W. H. M. Merkus, Stefan Romeijn, J. Fred Nagelkerke, J. Coos Verhoef, Hans E. Junginger
Publikováno v:
International Journal of Pharmaceutics. 185:73-82
N-trimethyl chitosan (TMC) polymers are quaternized chitosans in different degrees of trimethylation. These polymers enhance the absorption of macromolecules through mucosal epithelia by triggering the reversible opening of tight junctions and only a
Autor:
van der Kuy Ph, Stefan Romeijn, E. Marttin, N.G.M. Schipper, John Verhoef, Frans W. H. M. Merkus, W.A.J.J. Hermens
Publikováno v:
Advanced Drug Delivery Reviews. 36:41-57
Nasal drug delivery is an attractive approach for the systemic delivery of high potency drugs with a low oral bioavailability due to extensive gastrointestinal breakdown and high hepatic first-pass effect. For lipophilic drugs nasal delivery is possi
Autor:
Frans W. H. M. Merkus, John Verhoef, Stefan Romeijn, Wilbert M. Boek, Egbert H. Huizing, Kees Graamans
Publikováno v:
Acta Oto-Laryngologica. 119:98-101
Ciliary beat frequency (CBF) is one of the most important parameters of mucociliary clearance. Previously, we demonstrated that mucosa from chicken embryo trachea is a good substitute for human ciliated epithelium to study the effects on CBF of subst
Publikováno v:
Journal of Drug Targeting. 6:17-36
Cyclodextrins are used in nasal drug delivery as absorption enhancing compounds to increase the intranasal bioavailability of peptide and protein drugs. The most effective cyclodextrins in animal experiments are the methylated derivatives, dimethyl-b
Autor:
Christopher Cullander, Frans W. H. M. Merkus, J. Fred Nagelkerke, Stefan Romeijn, E. Marttin, J. Coos Verhoef
Publikováno v:
Pharmaceutical Research. 14:631-637
Purpose. To visualize the transport pathway(s) of high molecular weight model compounds across rat nasal epithelium in vivousing confocal laser scanning microscopy. Furthermore, the influence of nasal absorption enhancers (randomly methylated β-cycl
Publikováno v:
International Journal of Pharmaceutics. 141:151-160
The aim of the study was to determine the acute effects of nasal absorption enhancers on the morphology of the rat nasal epithelium in vivo. Examples of three classes of enhancers were studied: the cyclodextrins dimethyl-β-cyclodextrin 2% (w/v) and
Publikováno v:
Journal of Controlled Release. 41:69-75
The bioavailability of intranasally administered insulin in humans is very low, because insulin is a high molecular weight and hydrophilic substance. In healthy volunteers and diabetes patients some absorption enhancers proved to be very effective, i