Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Frans Schutgens"'
Autor:
Camilla Calandrini, Frans Schutgens, Rurika Oka, Thanasis Margaritis, Tito Candelli, Luka Mathijsen, Carola Ammerlaan, Ravian L. van Ineveld, Sepide Derakhshan, Sanne de Haan, Emmy Dolman, Philip Lijnzaad, Lars Custers, Harry Begthel, Hindrik H. D. Kerstens, Lindy L. Visser, Maarten Rookmaaker, Marianne Verhaar, Godelieve A. M. Tytgat, Patrick Kemmeren, Ronald R. de Krijger, Reem Al-Saadi, Kathy Pritchard-Jones, Marcel Kool, Anne C. Rios, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Ruben van Boxtel, Frank C. P. Holstege, Hans Clevers, Jarno Drost
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different
Externí odkaz:
https://doaj.org/article/06e35408aaed4de9ae4266eeecb8d988
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality. Matrix metalloprot
Externí odkaz:
https://doaj.org/article/190e56cc03954f1e86a475a350b710cb
Autor:
Arnaud Nicolas, Carola M. E. Ammerlaan, Linda Gijzen, Marianne K. Vormann, Paul Vulto, Maarten B. Rookmaaker, Frans Schutgens, Dorota Kurek, Hans Clevers, Fjodor A. Yousef Yengej, Henriëtte L. Lanz, Marianne C. Verhaar
Publikováno v:
Nature Protocols, 16(4), 2023-2050. Nature Publishing Group
Advanced in vitro kidney models are of great importance to the study of renal physiology and disease. Kidney tubuloids can be established from primary cells derived from adult kidney tissue or urine. Tubuloids are three-dimensional multicellular stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d9d6cfae864a7a1f35d11a739c7e16
https://doi.org/10.1038/s41596-020-00479-w
https://doi.org/10.1038/s41596-020-00479-w
A Perspective on a Urine-Derived Kidney Tubuloid Biobank from Patients with Hereditary Tubulopathies
Publikováno v:
Tissue Eng Part C Methods
Inherited kidney tubulopathies comprise a group of rare diseases with a significant societal impact, as lifelong treatment is often required and no therapies are available to prevent progression of renal damage. Diagnosis of inherited tubulopathies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbceef1a84ea555603dc940055173f9
https://doi.org/10.1089/ten.tec.2020.0366
https://doi.org/10.1089/ten.tec.2020.0366
Autor:
Linda, Gijzen, Fjodor A, Yousef Yengej, Frans, Schutgens, Marianne K, Vormann, Carola M E, Ammerlaan, Arnaud, Nicolas, Dorota, Kurek, Paul, Vulto, Maarten B, Rookmaaker, Henriette L, Lanz, Marianne C, Verhaar, Hans, Clevers
Publikováno v:
Nature protocols. 16(4)
Advanced in vitro kidney models are of great importance to the study of renal physiology and disease. Kidney tubuloids can be established from primary cells derived from adult kidney tissue or urine. Tubuloids are three-dimensional multicellular stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81a5beb23d23e1fc5c0ac7057b1d13a8
https://pubmed.ncbi.nlm.nih.gov/33674788
https://pubmed.ncbi.nlm.nih.gov/33674788
Autor:
Hans Clevers, Frans Schutgens
Publikováno v:
Annual review of pathology
Schutgens, F & Clevers, H 2020, ' Human Organoids : Tools for Understanding Biology and Treating Diseases ', Annual Review of Pathology: Mechanisms of Disease, vol. 15, pp. 211-234 . https://doi.org/10.1146/annurev-pathmechdis-012419-032611
Schutgens, F & Clevers, H 2020, ' Human Organoids : Tools for Understanding Biology and Treating Diseases ', Annual Review of Pathology: Mechanisms of Disease, vol. 15, pp. 211-234 . https://doi.org/10.1146/annurev-pathmechdis-012419-032611
Organoids are in vitro-cultured three-dimensional structures that recapitulate key aspects of in vivo organs. They can be established from pluripotent stem cells and from adult stem cells, the latter being the subject of this review. Organoids derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6155ff7a5ff045370dca2e061344f4c8
https://pubmed.ncbi.nlm.nih.gov/31550983
https://pubmed.ncbi.nlm.nih.gov/31550983
Publikováno v:
European Journal of Pharmacology, 790, 12. Elsevier
Organoids are self-organizing, multicellular structures that contain multiple cell types, represent organ structure and function, and can be used to model organ development, maintenance and repair ex vivo. Organoids, derived from embryonic stem cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c8f82be394e1ba538fcd8b1ba6c392
https://doi.org/10.1016/j.ejphar.2016.06.059
https://doi.org/10.1016/j.ejphar.2016.06.059
Autor:
Thanasis Margaritis, Camilla Calandrini, Jarno Drost, Tito Candelli, Hans Clevers, Ruben van Boxtel, Marry M. van den Heuvel-Eibrink, Harry Begthel, Rurika Oka, Philip Lijnzaad, Marianne C. Verhaar, Frans Schutgens, Sepideh Derakhshan, Maarten Rookmaker, Ronald R. de Krijger, Kathy Pritchard-Jones, Luka Mathijsen, Frank C. P. Holstege, Anne C. Rios, Ravian L. van Ineveld, Hinri Kerstens, Lars Custers, Carola Ammerlaan, Patrick Kemmeren
Publikováno v:
Cancer Research. 80:IA27-IA27
Recent advances in in vitro culture technologies, such as adult stem cell-derived organoids, have opened up new avenues for the development of novel, more physiologic human cancer models. Such preclinical models are essential for efficient translatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c8d958995099e6f693c6d283017c3c
https://doi.org/10.1158/1538-7445.pedca19-ia27
https://doi.org/10.1158/1538-7445.pedca19-ia27
Autor:
Ruben van Boxtel, Robert R G Vries, Edwin Cuppen, Hans Clevers, Marianne C. Verhaar, Francis Blokzijl, Maarten B. Rookmaaker, Frans Schutgens
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11190
Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11190-E11198. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11190-E11198. National Academy of Sciences
During kidney development, progressively committed progenitor cells give rise to the distinct segments of the nephron, the functional unit of the kidney. Similar segment-committed progenitor cells are thought to be involved in the homeostasis of adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4981a29895ea500a95c3273baff2ce5d
https://hdl.handle.net/1874/360184
https://hdl.handle.net/1874/360184
Publikováno v:
Nature Reviews Nephrology, 11(9), 546-54. Nature Publishing Group
Nature Reviews. Nephrology, 11(9), 546. Nature Publishing Group
Nature Reviews. Nephrology, 11(9), 546. Nature Publishing Group
Adult stem or progenitor cell organoids are 3D adult-organ-derived epithelial structures that contain self-renewing and organ-specific stem or progenitor cells as well as differentiated cells. This organoid culture system was first established in mur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e296d2a8ab931d5c204e3d29f9c12d
https://pubmed.ncbi.nlm.nih.gov/26215513
https://pubmed.ncbi.nlm.nih.gov/26215513