The transcriptional repressor TupA in Aspergillus niger is involved in controlling gene expression related to cell wall biosynthesis, development, and nitrogen source availability.

Autor: Doreen Schachtschabel, Mark Arentshorst, Benjamin M Nitsche, Sam Morris, Kristian F Nielsen, Cees A M J J van den Hondel, Frans M Klis, Arthur F J Ram

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78102 (2013)

The Tup1-Cyc8 (Ssn6) complex is a well characterized and conserved general transcriptional repressor complex in eukaryotic cells. Here, we report the identification of the Tup1 (TupA) homolog in the filamentous fungus Aspergillus niger in a genetic s

Externí odkaz: https://doaj.org/article/87a8baecbec6442f9c0bcac57976feda

Role of Retrograde Trafficking in Stress Response, Host Cell Interactions, and Virulence of Candida albicans

Autor: Scott G. Filler, Norma V. Solis, Yaoping Liu, Clemens J. Heilmann, Quynh T. Phan, Frans M. Klis, Aaron P. Mitchell

Publikováno v: Eukaryotic cell, vol 13, iss 2
Eukaryotic Cell, 13(2), 279-287. American Society for Microbiology

In Saccharomyces cerevisiae , the vacuolar protein sorting complexes Vps51/52/53/54 and Vps15/30/34/38 are essential for efficient endosome-to-Golgi complex retrograde transport. Here we investigated the function of Vps15 and Vps51, representative me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1226c2ceb510654fa61492cc4a9fc64
https://doi.org/10.1128/ec.00295-13

Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans

Autor: Iuliana V. Ene, Clemens J. Heilmann, Chris G. de Koster, Alice G. Sorgo, Frans M. Klis, Carol A. Munro, Alistair J. P. Brown, Louise A. Walker

Publikováno v: Proteomics
PROTEOMICS, 12(21), 3164-3179. Wiley-VCH Verlag
PROTEOMICS

The major fungal pathogen Candida albicans can occupy diverse microenvironments in its human host. During colonization of the gastrointestinal or urogenital tracts, mucosal surfaces, bloodstream, and internal organs, C. albicans thrives in niches tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185c46809cf5a743fa0d8252589e9034
http://europepmc.org/articles/PMC3569869

The Candida albicans cell wall protein Rhd3/Pga29 is abundant in the yeast form and contributes to virulence

Autor: Martin Schaller, Uwe Gross, Günther Weindl, Frans M. Klis, Dietmar Riedel, Rosalía Diez-Orejas, Albert D. de Boer, Henk L. Dekker, Oliver Bader, Piet W. J. de Groot, Michael Weig, Chris G. de Koster

Publikováno v: Yeast, 27(8), 611-624. John Wiley and Sons Ltd

The glycosylphosphatidylinositol-modified protein Rhd3/Pga29 of the human pathogen Candida albicans belongs to a family of cell wall proteins that are widespread among Candida species but are not found in other fungi. Pga29 is covalently linked to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18098027b4f038c52b23580e9e7abe4
https://doi.org/10.1002/yea.1790

Comparative Analysis of Transcriptome and Fitness Profiles Reveals General and Condition-Specific Cellular Functions Involved in Adaptation to Environmental Change in Saccharomyces cerevisiae

Autor: André Boorsma, Frans M. Klis, Alex Ter Beek, Klaas J. Hellingwerf, Gertien J. Smits, Stanley Brul, Jos A. Hageman, Johan A. Westerhuis, Anna Zakrzewska

Publikováno v: OMICS A Journal of Integrative Biology, 5, 14, 603-614
OMICS-A Journal of Integrative Biology, 14(5), 603-614
OMICS-A Journal of Integrative Biology 14 (2010) 5
Omics, 14(5), 603-614. Mary Ann Liebert Inc.

The transcriptional responses of yeast cells to a wide variety of stress conditions have been studied extensively. In addition, deletion mutant collections have been widely used to measure the combined effect of gene loss and stress on growth (fitnes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f95a7e25934eba5056cb10efb25606
https://doi.org/10.1089/omi.2010.0049