An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65.

Autor: Olivier R Costa, Katrijn Verhaeghen, Sarah Roels, Geert Stangé, Zhidong Ling, Daniel Pipeleers, Frans K Gorus, Geert A Martens

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0193670 (2018)

A disproportional increase of circulating GAD65 within hours from an intraportal islet allotransplantation has been validated as biomarker of beta cell loss and poor functional outcome. More sensitive assays are, however, needed to allow detection of

Externí odkaz: https://doaj.org/article/1c9880289ca64b3687bec2194a81b476

Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio.

Autor: Annelien Van Dalem, Simke Demeester, Eric V Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, Daniël Pipeleers, Ilse Weets, Frans K Gorus, Belgian Diabetes Registry

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0166702 (2016)

The hyperglycemic clamp test, the gold standard of beta cell function, predicts impending type 1 diabetes in islet autoantibody-positive individuals, but the latter may benefit from less invasive function tests such as the proinsulin:C-peptide ratio

Externí odkaz: https://doaj.org/article/ec837da0f8d54432a784129f6fbeaf44

Protein markers for insulin-producing beta cells with higher glucose sensitivity.

Autor: Geert A Martens, Lei Jiang, Katrijn Verhaeghen, Joanne B Connolly, Scott G Geromanos, Geert Stangé, Laurence Van Oudenhove, Bart Devreese, Karine H Hellemans, Zhidong Ling, Christiaan Van Schravendijk, Daniel G Pipeleers, Johannes P C Vissers, Frans K Gorus

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14214 (2010)

BACKGROUND AND METHODOLOGY: Pancreatic beta cells show intercellular differences in their metabolic glucose sensitivity and associated activation of insulin production. To identify protein markers for these variations in functional glucose sensitivit

Externí odkaz: https://doaj.org/article/ff70921e2dad4767b50291c97c665b97

Contributors

Autor: Peter Abrams, Joel T. Adler, Rodolfo Alejandro, Mohamed Alibashe-Ahmed, Ana Alvarez, Takayuki Anazawa, Axel Andres, Barbara Antonioli, Alan Apete, David A. Axelrod, Lionel Badet, David Baidal, Kaylene Barrera, Pierre-Yves Benhamou, Thierry Berney, Alain Gerald Bertoni, Federico Bertuzzi, Ugo Boggi, Caroline Bonner, Adel Bozorgzadeh, Julien Branchereau, Jonathan Bromberg, George W. Burke, Fanny Buron, Robert Caiazzo, Rossana Caldara, Stephanie S. Camhi, Diego Cantarovich, Massimo Cardillo, D. Castanares-Zapatero, Pierre Cattan, Suresh Rama Chandran, Erin Chang, Linda Chen, Mikael Chetboun, Pratik Choudhary, Gaetano Ciancio, Maria Pia Cicalese, Antonio Citro, C. Collienne, Caterina Conte, Claire Counter, Khaled Z. Dajani, Carly M. Darden, Francesco De Cobelli, Eelco J.P. de Koning, Hector De Leon, Nathalie Delalleau, Laura DiChiacchio, Jason B. Doppenberg, Cinthia B. Drachenberg, Erica Dugnani, Ty B. Dunn, Marten A. Engelse, Ahmed Farag, Alan Farney, Anne Elizabeth Farrow, Ibrahim Fathi, Jose Figueiro, Anneliese Flatt, Georgia Fousteri, Jonathan A. Fridell, Peter J. Friend, Giacomo Gastaldi, Valery Gmyr, Javier Gonzalez, Jeevan Prakash Gopal, Frans K. Gorus, Masafumi Goto, Mitsukazu Gotoh, Michel Greget, Dominique Grenet, Paolo Antonio Grossi, Rainer W.G. Gruessner, Angelika C. Gruessner, David I. Harriman, Wayne J. Hawthorne, Jarl Hellman, Brenda Lee Holbert, Thomas Hubert, Sara Iacopi, Marco Infante, Peter Jacob, Paul Johnson, Raja Kandaswamy, Georges Karam, Dixon B. Kaufman, W.F. Kendall Jr, Clark D. Kensinger, Norma S. Kenyon, Julie Kerr-Conte, Delphine Kervella, Laurence Kessler, Romain Kessler, Bart Keymeulen, Olle Korsgren, Sandrine Lablanche, Muhaib Lakhani, Neeraj Lalwani, P.F. Laterre, Michael C. Lawrence, Frances Tangherlini Lee, Roger Lehmann, Elina Linetsky, Barbara Ludwig, Torbjörn Lundgren, Xunrong Luo, SriGita Madiraju, Paola Maffi, Paola Magistretti, Kristell Le Mapihan, James F. Markmann, Geert Martens, Paulo N. Martins, Francesco Antonio Mazzotta, Kavya Chitra Mekala, Raffaella Melzi, Alessia Mercalli, Paolo Monti, Mahmoud Morsi, Irene Mosca, M. Mourad, Anand S. Rathnasamy Muthusamy, Rita Nano, Bashoo Naziruddin, Christian Noel, John O’Callaghan, Jon S. Odorico, Anne Olland, E.C. Opara, Giuseppe Orlando, Nathalia Padilla, John C. Papadimitriou, Vassilios E. Papalois, Klearchos K. Papas, Gianni Pasquetti, François Pattou, Silvia Pellegrini, Nadine Pernin, Vittorio Grazio Perrone, Lorenzo Piemonti, Rutger Ploeg, John A. Powelson, Alberto Pugliese, Shanthini K. Rajan, Karthik V. Ramanathan, Violeta Raverdy, Robert R. Redfield, John Renz, Michael R. Rickels, Charles G. Rickert, Camillo Ricordi, Jeffrey Rogers, Joseph R. Scalea, Jesse D. Schold, Hanne Scholz, Antonio Secchi, Oscar K. Serrano, A.M. James Shapiro, Sidharth Sharma, Edward Sharples, James A.M. Shaw, Sanjay Sinha, Carlo Socci, Jean-Paul G. Squifflet, Peter G. Stock, Robert J. Stratta, David E.R. Sutherland, Manfredi Tesauro, Olivier Thaunat, Julien Thévenet, Christoph Troppmann, Marie-Christine Vantyghem, Francesco Vendrame, Massimo Venturini, Rodrigo Vianna, Fabio Vistoli, Bengt von Zur-Mühlen, X. Wittebole, Anne Wojtusciszyn, Arya Zarinsefat, Asha Zimmerman

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e433aba2e57eb1cb1a8a229cb3ca7c3d
https://doi.org/10.1016/b978-0-12-814833-4.09992-5

Hyperglycemic Clamp and Oral Glucose Tolerance Test for 3-Year Prediction of Clinical Onset in Persistently Autoantibody-Positive Offspring and Siblings of Type 1 Diabetic Patients

Autor: Eric V, Balti, Evy, Vandemeulebroucke, Ilse, Weets, Ursule, Van De Velde, Annelien, Van Dalem, Simke, Demeester, Katrijn, Verhaeghen, Pieter, Gillard, Christophe, De Block, Johannes, Ruige, Bart, Keymeulen, Daniel G, Pipeleers, Katelijn, Decochez, Frans K, Gorus, R, Van Heyste

Publikováno v: The journal of clinical endocrinology and metabolism

Context and Objective: In preparation of future prevention trials, we aimed to identify predictors of 3-year diabetes onset among oral glucose tolerance test (OGTT)- and hyperglycemic clamp-derived metabolic markers in persistently islet autoantibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c3221a1ff92ff9d33ff65889f6f44e
https://doi.org/10.1210/jc.2014-2035